Clinical trials: Ophthalmic Surgery
Macular Hole
Internal Limiting Membrane Peeling for Large Macular Holes
Rational of the study: for macular holes larger than 400 µm the rate of failure is of more than 20%. It is for these eyes that it is necessary to show the benefit of internal limiting membrane (ILM) peeling in term of vision and…
- Trial name
- NCT00190190
- Testing
- With Peeling of Limiting the Intern of the Retina, Internal limiting membrane peeling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cataract Surgery
Study of DE-108 Ophthalmic Solution in Patients Who Are Scheduled for Cataract Surgery
The purpose of this study is to evaluate superior efficacy of DE-108 ophthalmic solution to that of Levofloxacin 0.5% ophthalmic solution as well as safety of the former used for perioperative bacteria eradication in patients who…
- Trial name
- NCT02573610
- Testing
- DE-108, Levofloxacin 0.5%
- Where
- 6 sites in South Korea
- Volunteers
- 576 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Glaucoma, Progression
Visual Field Progression and RNFL Change After PreserFlo MicroShunt Implantation
The trabeculectomy is the gold standard in glaucoma surgery, nevertheless often postoperative interventions have to be done. (1),(2) The PreserFlo MicroShunt (Santen, Osaka, Japan) implantation occurs without critical steps of…
- Conditions
- Glaucoma, Progression, Surgery
- Trial name
- NCT06174324
- Testing
- PreserFlo Microshunt
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Klinikum Klagenfurt am Wörthersee
Pterygium
Prospective Randomized Pilot Study Comparing Inferior Versus Superior Conjunctival Autografts for Primary Pterygia
The purpose of this study is to determine if there is any difference in the surgical time when the surgery is performed with a graft taken from under the upper lid versus lower lid.
- Trial name
- NCT01261455
- Testing
- Location of the autograft taken following pterygium excision
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cataract
Dexmedetomidine Versus Midazolam for Peribulbar Block
50 patients of both sexes, ages 18 to 75, who were scheduled for cataract surgery and had physical status I or II according to the American Society of Anesthesiologists were included in this study.
- Trial name
- peribulbar (NCT06784843)
- Testing
- Dexmedetomidine as an adjuvant to local anesthesia for peribulbar block, Midazolam as an adjuvant to local anesthesia for peribulbar block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Suez Canal University
Cataract, Juvenile
Optic Capture Without Anterior Vitrectomy in Pediatric Cataract Surgery
Purpose: To compare two pediatric cataract surgery procedures: intraocular lens (IOL) optic capture without anterior vitrectomy (AV) and in-the-bag IOL implantation with AV.
- Trial name
- NCT05461040
- Testing
- optic capture, In-the-bag implantation of Intraocular lens
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Ege University
Cataract
PREVAIL VII: Cataract Surgery in Ebola Survivors
Objective: Zaire ebolavirus is a single-stranded RNA virus associated with high morbidity and mortality. The most recent epidemic of Ebola virus disease (EVD) in West Africa resulted in over 11,000 deaths and disabling sequelae…
- Trial name
- NCT03309020
- Testing
- Cataract surgery
- Where
- Liberia
- Volunteers
- 37 people
- Sponsor
- National Eye Institute (NEI)
Optic Nerve Sheath
The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD)…
- Trial name
- NCT02003768
- Testing
- Propofol, Desflurane
- Sponsor
- Yonsei University
Strabismus
Basic Intermittent Exotropia and Risk Factors for Postoperative Overcorrection and Under Correction
To evaluate preoperative risk factors for overcorrection and undercorrection following surgery for basic intermittent exotropia such as axial length of the globe, refractive error, age and sex
- Trial name
- NCT03153423
- Testing
- Strabismus surgery
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Minia University
Cataracts
Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients
This study will test the effectiveness of an intraocular lens treated with heparin in reducing or preventing inflammation after cataract surgery in patients with uveitis.
- Trial name
- NCT00001311
- Testing
- heparin-surface modified intraocular lens
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Eye Institute (NEI)
Glaucoma
Use of Ranibizumab With Mitomycin C During Trabeculectomy
The purpose of the study is to study the safety of the combination of ranibizumab and MMC vs monotherapy MMC vs intravitreal ranibizumab injection in patients with glaucoma.
- Trial name
- OCTOPUS (NCT00661583)
- Testing
- Ranibizumab, Ranibizumab and MMC, MMC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Post-Op Complication, Raised Ocular Pressure
Aqueous Release to Treat IOP Spikes Post-cataract Surgery
Intraocular pressure (IOP) rise after cataract surgery is an important and common problem. Over 300,000 cataract operations are done per year in the United Kingdom alone.
- Trial name
- NCT03500809
- Testing
- Aqueous release of the wound
- Volunteers
- 20 people
- Sponsor
- Bedford Hospital NHS Trust
Meibomian Gland Dysfunction, Cataract
Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye
Dry Eye Disease (DED) is a disease of the ocular surface which may be secondary to a variety of causes, including cataract surgery.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Surgery--Complications, Dry Eye
- Trial name
- LIPICAT (NCT05062564)
- Testing
- LipiFlow Thermal pulsation system, Eyelid warm compresses plus massages
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Primary Open Angle Glaucoma
Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans
The aim is to perform a randomised feasibility trial preceding a large prospective randomised controlled trial (RCT) comparing three surgical methods - trabeculectomy with Mitomycin C (MMC), primary Baerveldt tube with MMC and…
- Trial name
- PEACE (NCT02989207)
- Testing
- Trabeculectomy, Baerveldt tube surgery, mitomycin-C
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Coordination Impairment
Physical Activity on Eye Hand Coordination Post Strabismus Surgery
The aim of this study is to determine the effect of physical activity on eye hand coordination in patient with amblyopia after strabismus surgery.
- Trial name
- NCT06759792
- Testing
- eye hand coordination exercises
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Amany Refaat Mohamed Abdel Wahid
Cataract
Posterior Assisted Levitation of Dropped Nucleus
Dropping of nucleus is a common complication during cataract extraction by phacoemulsification. The investigators describe a new technique to retrieve the dropped nucleus by using an instrument called Pars Plana Levitator…
- Trial name
- PAL (NCT00974844)
- Where
- Pakistan
- Volunteers
- 14 people
- Sponsor
- Dow University of Health Sciences
Laparoscopic Surgery
The Impact of Anesthesia and Positioning on Cerebral Blood Flow and Pressure in Patients Undergoing Laparoscopic Surgery
The aim of this observational study was to understand the effect of ReverseTrendelenburg position, Trendelenburg position on intracranial pressure and carotid blood flow in patients undergoing laparoscopic surgery.
- Trial name
- NCT06669689
- Testing
- operating position, pneumoperitoneum
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaguang Duan
Blindness
Pars Plana Surgical Capsulotomy for Posterior Capsular Opacification
Cataract is a leading cause of Global blindness. After cataract surgery nearly half of the people become blind due to posterior capsular opacification. The only solution for this problem is LASER capsulotomy.
- Trial name
- Capsulotomy (NCT00964613)
- Volunteers
- 176 people
- Sponsor
- Dow University of Health Sciences
Optic Nerve Sheath Diameter
Effect of Sevoflurane and Propofol on the Optic Nerve Sheath Diameter
In the present study, we compare the effect of sevoflurane and propofol on the optic nerve sheath diameter in patients undergoing middle ear surgery.
- Trial name
- NCT04955925
- Testing
- Ultrasound examination of the optic nerve sheath diameter
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- SMG-SNU Boramae Medical Center
Large Angle Exotropia
True Muscle Transplantation Surgery Versus Augmented Semi Hang Back Recession in Large Angle Exotropia: Evaluation of Efficacy and Lateral Gaze Incomitance
This a randomized clinical trial comparing True muscle transplantation surgery versus Augmented Semi hang back recession for treatment of large angle exotropia
- Trial name
- NCT07784842
- Testing
- True Muscle Transplantation Surgery, Augmented Semi hang back Recession
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Hassnaa Mohamed Abdelhameed Ahmed
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