Clinical trials: Ophthalmic Surgery
Cataract
Monovision vs Multifocal Lens Insertion in Cataract Patients
The investigators would like to assess whether monovision correction of multifocal lens insertion provides more satisfaction to cataract patients following an uncomplicated phacoemulsification surgery.
- Trial name
- NCT01998698
- Testing
- Phacoemulsification surgery
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Democritus University of Thrace
Macular Hole, Epiretinal Membrane
Optical Coherence Tomography - Rescan During Dissection of Macular Membranes
In our study , the investigators will use the microscope with OCT ( Lumera with RESCAN OCT ) coupled to assess the extent , depth and change of retinal architecture in the perioperative period .
- Conditions
- Macular Hole, Epiretinal Membrane, Traction Syndrome Vitreomacular, Proliferative Vitreoretinopathy
- Trial name
- NCT02748421
- Testing
- Lumera Microscope with OCT RESCAN, Conventional Microscope
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Retinal Detachment
Ursodeoxycholic Acid (UDCA) as a Neuroprotective Adjuvant Treatment to Rhegmatogenous Retinal Detachment Surgery
This study is indicated for patients with extended rhegmatogenous retinal detachment (RRD) (≥ 2 quadrants) with macula OFF lasting 7 days or less, pseudophakic or aphakic, and scheduled to undergo surgical intervention with…
- Trial name
- UDCA (NCT06294847)
- Testing
- Ursolvan
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Hopital Foch
Pterygium
Corneal Topographic Changes After Pterygium Surgery
The purpose of the study is to assess the corneal topographic changes after primary pterygium surgery
- Trial name
- NCT05026307
- Testing
- Excision of pterygium
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Sohag University
Cataract, Endothelial Cell Density
Trial Comparing miLOOP Device Assisted Phacoemulsification vs Standard Surgery for Dense Cataracts: Effects on Endothelial Cell Loss, Energy Use, and Vision Recovery
The goal of this clinical trial is to find out if using the miLOOP device during cataract surgery confers additional protection against cornea (endothelial) cells loss by reducing the amount of ultrasound energy needed.
- Conditions
- Cataract, Endothelial Cell Density, Cumulative Dispersive Energy
- Trial name
- NCT07898007
- Testing
- The miLOOP utilizes a nickel-titanium (nitinol) loop to ensnare and exert centripetal cutting forces on the lens nucleus with decreasing loop diameter, Conventional phacoemulsification cataract surgery
- Where
- Malaysia
- Volunteers
- 68 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Age-Related Macular Changes, Age-Related Macular Degeneration
Effects of Sun Filters on Age-related Macular Degeneration in People With Lens Implants
This study will test a new method for preventing worsening of age-related macular degeneration (AMD) and for developing imaging methods to follow the very earliest microscopic changes in the disease.
- Conditions
- Age-Related Macular Changes, Age-Related Macular Degeneration, Cataract and IOL Surgery, Retinal Photochemistry
- Trial name
- NCT00487838
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Graves Ophthalmopathy
Analysis Between the Results of Two Surgical Techniques of Orbital Decompression in Patients With Graves Orbitopathy
Randomized prospective clinical trial, aiming to compare two techniques of orbital decompression. Patients with Graves orbitopathy in the inactive phase for at least 6 months will be divided in two groups; one group will be…
- Trial name
- NCT03278964
- Testing
- Orbital decompression
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo General Hospital
Macular Holes
To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes.
To compare anatomic and functional results, and to evaluate postoperatively the healing process in 3 different techniques for the closure of the refractory macular holes (MH).
- Trial name
- NCT05396209
- Testing
- Hydrated Amniotic Membrane Plug, ILM filling, Conventional ILM peeling
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Conjunctival Bacterial Flora
Effectiveness of Topical 0.5% Levofloxacin to Reduce the Conjunctival Bacterial Flora Before Intraocular Surgery
The purpose of this study is to determine whether additional topical application of 0.5% levofloxacin is more effective in reducing the load of the conjunctival bacterial flora in patients scheduled for intraocular surgery than…
- Trial name
- NCT00491049
- Testing
- 0.5% levofloxacin eye drops
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cataract
No Drop Post-Op Cataract Surgery
This study evaluates the effect of Intraocular Phenylephrine/Ketorolac Infusion on Retinal Thickness and Macular Edema in Cataract Surgery.
- Trial name
- NCT03864133
- Testing
- Omidria
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Wake Forest University Health Sciences
Bilateral Cataract, Unilateral Cataract
Comparison of the Safety and Efficacy of Ophtesis Bio 3% With a Similar 3% Sodium Hyaluronate OVD
Prospective, randomized, subject/evaluator-masked post market clinical study at up to 2 sites at Gemini eye clinic in Czech Republic. Randomization will be done by the eye surgeon.
- Trial name
- NCT05832749
- Testing
- Ophtesis Bio 3% ophthalmic viscosurgical device, Healon Endocoat 3% ophthalmic viscosurgical device
- Where
- 3 sites in Czechia
- Volunteers
- 296 people
- Sponsor
- Gemini Eye Clinic
Emulsification of Silicone Oil in Eye Following Surgical Procedure
Correlation Between Silicone-oil Related Ocular Complications and ITMES Score (CLIN-ITEMS)
Prospective, multicentric, observational study aimed to evaluate the correlation between the value of the InTraocular EMulsion of Silicone oil (ITMES) score assessed at clinical examination and silicone oil-related ocular…
- Trial name
- CLIN-ITEMS (NCT06198738)
- Volunteers
- 323 people
- Sponsor
- Cliniche Humanitas Gavazzeni
Astigmatism
Rotational Stability After Nanoflex Collamer Toric Intraocular Lens Implantation in Astigmatic Patients
This study aims to assess the rotational stability of the new collameric Nanoflex toric intraocular lens (T-IOL) by STAAR inserted in astigmatic patients after cataract surgery.
- Trial name
- T-IOL (NCT02412215)
- Testing
- Phacoemulsification with toric Nanoflex IOL implantation, NanoFlex toric Intraocular Lens
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Glaucoma, Open-Angle
Study of an Interposition Supraciliary Implant in Patients With Open Angle Glaucoma
The purpose of this study is to prolong observational follow-up up to 36 months of patients already implanted with a novel interposition supraciliary implant.
- Trial name
- SAFARI FU (NCT05159817)
- Where
- Armenia
- Volunteers
- 19 people
- Sponsor
- Ciliatech
Cataract
In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery
To evaluate the clinical outcomes with optometrist pre-surgical insertion of DEXTENZA in the clinical office setting in patients undergoing same-day cataract surgery compared to standard of care steroid therapy.
- Trial name
- Prepare (NCT05023304)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical prednisolone acetate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Macular Holes
Comparison of Two Intraocular Gas Injection Techniques in Macula Hole Surgery
To undertake a prospective randomized clinical trial of vitrectomy and gas tamponade to treat macular hole, utilizing a small amount of undiluted C3F8 (perfluoropropane) versus a large amount of diluted C3F8 versus a small amount…
- Trial name
- NCT04527848
- Testing
- small amount of undiluted C3F8
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Universidade Federal de Pernambuco
Pterygium
Prospective Randomized Pilot Study Comparing Inferior Versus Superior Conjunctival Autografts for Primary Pterygia
The purpose of this study is to determine if there is any difference in the surgical time when the surgery is performed with a graft taken from under the upper lid versus lower lid.
- Trial name
- NCT01261455
- Testing
- Location of the autograft taken following pterygium excision
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cataract
Anterior Chamber Depth Variability Between Two Lenses With Different Materials
Compare the change of the Anterior chamber depth (ACD) variability between the Clareon and the AcrySof Intraocular lens (IOL) after implantation over 6 months.
- Trial name
- NCT03751215
- Testing
- Cataract surgery
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Oesophageal Cancer
Laser Speckle Contrast Imaging, Surgical Eye & ICG Fluorescence Imaging for Perfusion Assessment of the Gastric Conduit
Rationale Globally, esophageal cancer is the seventh most common cancer type, with over half a million cases reported in 2020. The survival of gastroesophageal cancer is poor and the prognosis is primarily determined by the…
- Trial name
- CONDOR-I (NCT05685862)
- Testing
- Laser Speckle Contrast Imaging using the PerfusiX-Imaging device
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Frisius Medisch Centrum
Epiretinal Membrane
Epiretinal Fibrosis, Effect of Early Surgery
The goal of this randomized clinical trial is to investigate when it is optimal to treat the eye disease epiretinal fibrosis. Hypothesis: In a population of patients with symptomatic idiopathic epiretinal fibrosis and visual…
- Trial name
- epitell (NCT00902629)
- Testing
- Early surgery
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Glostrup University Hospital, Copenhagen
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