Clinical trials: Ophthalmopathy
Retinitis Pigmentosa
Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum
Objectives: To study the immediate effect and the persistent effect of Lycium barbarum (LB) treatment on retinal functions, especially the cone function, and retinal structure in patients with retinitis pigmentosa (RP) Design…
- Trial name
- NCT02244996
- Testing
- Lycium Barbarum
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Myopia, Orthokeratology
Effectiveness of Myopia Control by Breath-O Correct Orthokeratology Lenses
This is a 24-month longitudinal randomized controlled trial aiming to evaluate the effectiveness of myopia control by Breath-O correct orthokeratology lenses in different myopia progression groups classified according to their…
- Trial name
- NCT03919396
- Testing
- Breath-O orthokeratology lenses
- Where
- Hong Kong
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Dry Eye Disease
The Effects of Diquafosol Tetrasodium Ophthalmic Solution, 2% in Subjects With Dry Eye Disease (P08637)
The purpose of this study is to confirm the safety and efficacy of diquafosol tetrasodium ophthalmic solution, 2% vs. placebo, in subjects with dry eye disease.
- Trial name
- NCT00831662
- Testing
- Diquafosol tetrasodium ophthalmic solution, 2%
- Volunteers
- 490 people
- Sponsor
- Merck Sharp & Dohme LLC
Dry Eye Disease
BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution Trial
Trial RX01-BL1107-1202 is designed to identify the lowest effective concentration of BL1107 required for complete resolution of conjunctival hyperemia in participants with DED.
- Trial name
- BRIGHT (NCT07778888)
- Testing
- BL1107
- Volunteers
- 20 people
- Sponsor
- Bausch & Lomb Incorporated
Graves Ophthalmopathy
Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy
The purpose of this study is to examine the effects of Azithromycin (a macrolide class antibiotic), given three times weekly, for patients with active moderate-severe, non sight-threatening, Graves Orbitopathy.
- Trial name
- NCT01379196
- Testing
- Azithromycin
- Sponsor
- Rabin Medical Center
Neovascular Age-related Macular Degeneration, Macular Degeneration
Photodynamic Therapy for PDA in NV AMD
The purpose of this prospective observational study is to assess the potential clinical effects of adjunctive verteporfin photodynamic therapy (PDT) for persistent disease activity among patients with neovascular age-related…
- Trial name
- NCT02452840
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Astigmatism
A Clinical Comparison of Two Soft Toric Contact Lenses
The aim of this study is to compare the short-term clinical performance of two toric contact lenses.
- Trial name
- NCT06758089
- Testing
- Lens 1 (ocufilcon D), Lens 2 (somofilcon A)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- CooperVision International Limited (CVIL)
Healthy Volunteers, Relative Afferent Pupil Defect
The PUPIL Study - Automated, Quantitative Pupil Assessment Using Binocular OCT
In current, clinical ophthalmology, a range of specialised testing allows comprehensive evaluation of ocular health. These tests have typically evolved over many years to ensure their clinical validity.
- Conditions
- Healthy Volunteers, Relative Afferent Pupil Defect, Pupil Anomaly
- Trial name
- NCT03081468
- Testing
- Binocular OCT prototype, Konan RAPDx
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Wet Macular Degeneration
Brolucizumab vs. Aflibercept for Retinal Angiomatous Proliferation
This is a prospective randomised study comparing two intravitreal antiVEGF drugs - brolucizumab and aflibercept - in the treatment of retinal angiomatous proliferation (RAP).
- Trial name
- BEY-RAP (NCT04698850)
- Testing
- Aflibercept 40 MG/ML [Eylea], Brolucizumab-Dbll 120 MG/ML [Beovu], Ranibizumab 6 MG/ML [Lucentis]
- Where
- Czechia
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Corneal Disease, Blepharitis
Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa
In vivo confocal microscopy (IVCM) used in tertiary care ophthalmology centers is performed with two reflectance microscopes attached on a mounting with limited movement along the XYZ axes.
- Conditions
- Corneal Disease, Blepharitis, Lacrimal Apparatus Diseases
- Trial name
- INNOV-EYE (NCT02386774)
- Testing
- Handheld IVCM Vivascope 3000 (Caliber/Mavig) anesthesic eyedrop : oxybuprocaïne Thea 1,6 mg/0,4 ml, Multifluorescence IVCM vivascope 1500 ML (Caliber/Mavig), microangiography
- Where
- 2 sites in France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Geographic Atrophy, Age-Related Macular Degeneration
Geographic Atrophy Treatment Evaluation
The purpose of this study was to evaluate the safety and efficacy of AL-8309B Ophthalmic Solution versus Vehicle administered as a topical ocular drop for the treatment for geographic atrophy (GA) secondary to age-related macular…
- Trial name
- GATE (NCT00890097)
- Testing
- AL-8309B Ophthalmic Solution, AL-8309B Vehicle
- Volunteers
- 772 people
- Sponsor
- Alcon Research
Neuromyelitis Optica Spectrum Disorders
A Phase III Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Neuromyelitis Optica Spectrum Disorders
The purpose of this study is to initially observe the safety and effectivity of RC18 in Participants with Neuromyelitis Optica Spectrum Disorders.
- Trial name
- NCT03330418
- Testing
- RC18 160 mg
- Where
- China
- Volunteers
- 178 people
- Sponsor
- RemeGen Co., Ltd.
Evaporative Dry Eye
Quality of Life Improvement in Dry Eye Patients After Intense Pulsed Light Therapy Compared to Punctal Plugs
Dry eye disease (DED) is a widely spread disorder of tears and ocular surface affecting hundreds of millions around the world. Manifestations resulting from moderate to severe DED have significant effects on the patient's quality…
- Trial name
- NCT05331924
- Testing
- IPL therapy, Punctal plugs
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Primary Open Angle Glaucoma (POAG), Ocular Hypertension (OHT)
Safety Study of Latanoprost Slow Release Insert
This study is a phase 1, open-label, dose-escalation, safety and tolerability study, which will be conducted at one study site. This study will include 3 cohorts. Each cohort will have approximately 5 subjects.
- Trial name
- Latanoprost SR (NCT01180062)
- Testing
- Latanoprost, Arm 2, Latanoprost SR insert
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Daniel Moore
Exotropia
Comparison of Medial Rectus Resection and Plication in Exotropic Patients
Purpose: To determine the surgical outcomes of the plication technique in comparison with the resection method on exotropic patients.
- Trial name
- NCT03768362
- Testing
- Plication strabismus surgery, Resection strabismus surgery
- Volunteers
- 52 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Dry Eye, Sjogren Syndrome
Comparing Effect of Topical Tacrolimus 0.03% Versus Cyclosporine 0.05% in Dry Eyes of Secondary Sjogren Syndrome
Evaluation of the effect of topical application of Tacrolimus 0.03% (FK506) eye drops versus Cyclosporine 0.05% eye drops in treatment of dry eye in Secondary Sjogren Syndrome.
- Trial name
- NCT03865888
- Testing
- Cyclosporins, Tacrolimus
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Pavly Moawd
Ophthalmological Disorder
Multi-Center Study to Determine the Role of Fatty Acids in Serum in Preventing Retinopathy of Prematurity (MDM)
The study is a Randomized Intervention, Multi-Center Study to Determine the Role of Fatty Acids in Serum and Breast Milk in preventing Retinopathy of Prematurity Subjects who meet all inclusion and none of the exclusion criteria…
- Trial name
- MDM (NCT03201588)
- Testing
- Formulaid
- Where
- 3 sites in Sweden
- Volunteers
- 210 people
- Sponsor
- Göteborg University
Glaucoma
Prospective Constitution of Database Gathering Data of Patients Suffering From Glaucoma Followed at University Hospital of Grenoble
Few publications provide information on the natural history of glaucoma, outside of clinical trials do not always reflect what is observed in common situation for various reasons (specific selection criteria and sometimes…
- Trial name
- BDD_GLAUCOME (NCT02867527)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Glaucoma
Evaluation of Filtering Blebs Using the "Wuerzburg Bleb Classification Score" Compared to Other Clinical Findings, e.g. the Intraocular Pressure (IOP)
It is well established to assess the functionality of a filtering bleb by intraocular pressure (IOP), either as an absolute value or as a percent reduction, and by the need of additional antiglaucoma drugs.
- Trial name
- NCT01287442
- Testing
- Trabeculectomy
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Non-infectious Intermediate and Posterior Uveitis
Combination Daclizumab/Denileukin Diftitox to Treat Uveitis
This study will determine whether treatment with a combination of the drugs daclizumab and denileukin diftitox can eliminate the need for long-term daclizumab treatment in adult patients with uveitis.
- Trial name
- NCT00326508
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)