Clinical trials: Opiate Substitution Treatment
Opioid-Related Disorders
Youth Opioid Recovery Support: Improving Care Systems
Opioid addiction, also referred to as opioid use disorder, among young people is a growing health concern for patients and their families.
- Trial name
- YORS (NCT04015115)
- Testing
- Youth Opioid Recovery Support service model
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hepatitis C
Reaching mEthadone Users Attending Community pHarmacies With HCV
Hepatitis C Virus (HCV) is a blood-borne virus that damages the liver and is a major public health threat globally. Most individuals infected with HCV are unaware of it and show no symptoms until presenting with incurable, fatal…
- Trial name
- REACH-HCV (NCT03935906)
- Testing
- Reach Pathway, Education-only Pathway
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 1,410 people
- Sponsor
- University of Dundee
Hepatitis C, Chronic, Opioid Dependence, on Agonist Therapy
Integrated Treatment of Hepatitis C Virus Infection
INTRO-HCV is a multicentre randomised controlled clinical trial that will compare the efficacy of integrated treatment of chronic hepatitis C virus infection (HCV) within medically assisted rehabilitation (MAR) clinics providing…
- Trial name
- INTRO-HCV (NCT03155906)
- Testing
- Health care delivery
- Where
- 2 sites in Norway
- Volunteers
- 298 people
- Sponsor
- Haukeland University Hospital
Substance-related Disorders
PHAST: Physical Activity in Substitution Therapy
The aim is to examine the effect of exercise (EX) training on individuals currently receiving ST - either opiate replacement therapy (ORT) or heroin-assisted treatment (HAT) - for their opiate dependence.
- Trial name
- PHAST (NCT02309021)
- Testing
- Sport, Non-sport activities
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Basel, Switzerland
Opiate-Related Disorders, Cocaine-Related Disorders
Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292110
- Testing
- Methadone, Contingency Management, Methadone dose
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Chronic, Opioid-Related Disorders
Interferon-free Antiviral Treatment of Chronic Hepatitis C Virus Infection Among Opioid-substituted Patients
The primary objective of study will be to evaluate the effectiveness of interferon-free direct acting antivirals (IFN-free DAAs) in the treatment of chronic hepatitis C virus (HCV) among patients in opioid-substitution treatment…
- Trial name
- INFO (NCT02969668)
- Where
- 18 sites in Germany
- Volunteers
- 326 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Neonatal Abstinence Syndrome
The Alberta Neonatal Abstinence Syndrome Mother-Baby Care ImprovEmeNT Program
Neonatal Abstinence Syndrome (NAS), is a common and costly problem in Alberta that affects approximately 250 babies per year exposed to drugs during pregnancy. Unfortunately, this has become more common in the last 10 years.
- Trial name
- NASCENT (NCT05226624)
- Testing
- Rooming-in care, Baseline standard of care
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of Alberta
HIV Infections, Heroin Dependence
Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chennai, India
Though the HIV epidemic in India is predominantly among heterosexual populations, it is estimated that there are approximately 1.1 million injection drug users (IDUs) in India with HIV prevalence as high as 64% among IDUs in…
- Trial name
- DAART+ (NCT00709007)
- Testing
- Directly Administered Antiretroviral Therapy (DAART), SAT
- Where
- India
- Sponsor
- Johns Hopkins University
Opiate Dependence
Electronic Compliance Monitoring in Opioid Substitution Treatment
The purpose of this study is to improve unsupervised dosing of opioid substitution medications. The aim of the study is to examine whether electronic compliance monitoring provides some advantages to patients'treatment and what…
- Trial name
- EHSO (NCT01182402)
- Testing
- Compliance monitoring with electronic device
- Where
- Finland
- Volunteers
- 37 people
- Sponsor
- Kuopio University Hospital
Opioid-use Disorder, Pain, Acute
Acute Pain Management in Patients on Opioid Replacement Therapy
This is an outpatient randomized within subject placebo-controlled human laboratory investigation of analgesia (as assessed with quantitative sensory testing; QST) from ketamine alone and in combination with hydromorphone in…
- Trial name
- NCT03933865
- Testing
- HYDROmorphone Injectable Solution, Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
HIV - Human Immunodeficiency Virus
HIV Prevention With PrEP Among People on Opioid Replacement Therapy
The purpose of this study is to assess the feasibility and acceptability of providing oral pre-exposure prophylaxis (PrEP) and opioid agonist therapy (OAT) simultaneously in existing pharmacy-based programs operating in Alberta…
- Trial name
- OAT-PrEP (NCT07160075)
- Testing
- Simultaneous administration of OAT and oral PrEP at existing pharmacy-based programs
- Where
- 6 sites in Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Cara Spence
Opioid Substitution Treatment Clinics, Patients
Pilot Study of Methadone Patient Access to Collaborative Treatment: a HEAL Initiative
Examine the preliminary effect of the MPACT intervention on methadone treatment retention, in treatment overdose and patient trauma symptoms.
- Conditions
- Opioid Substitution Treatment Clinics, Patients, Staff
- Trial name
- MPACT (NCT06513728)
- Testing
- MPACT Intervention
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Drug Dependence, Substance Use Disorders
Automated Recovery Line for Medication Assisted Treatment
If shown to be effective, the Recovery Line would provide an inexpensive, transportable, and easy to use treatment to improve substance abuse outcomes for medication assisted treatment.
- Trial name
- NCT02124980
- Testing
- Recovery Line
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Substance-Related Disorders
Integrated Exercise Program in Opioid Agonist Therapy Clinics
Background: Drug use is associated with unhealthy lifestyle choices, resulting in adverse social and health consequences. Particular people with opioid dependence have high morbidity and reduced quality of life.
- Trial name
- BAReAktiv (NCT05242848)
- Testing
- Exercise intervention
- Where
- 2 sites in Norway
- Volunteers
- 309 people
- Sponsor
- Haukeland University Hospital
Substance-Related Disorders
Benzodiazepines in Opiate Replacement Therapy
Drug-related deaths (DRD) are a significant and increasing public health problem in Scotland. Benzodiazepines and BZD-type substances (BZD) are increasingly implicated in DRD.
- Trial name
- BENZORT (NCT04622995)
- Testing
- Benzodiazepine
- Where
- United Kingdom
- Volunteers
- 46,899 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Opioid-Related Disorders, Opiate Substitution Treatment
Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder
This is a non-inferiority randomized clinical trial that will compare slow release oral morphine vs methadone as a second line oral treatment for opioid use disorder.
- Conditions
- Opioid-Related Disorders, Opiate Substitution Treatment, Morphine, Methadone
- Trial name
- pRESTO (NCT03948464)
- Testing
- Slow release oral morphine (SROM), Methadone
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- M. Eugenia Socias
Opioid Use Disorder
Investigation of the Relationship Between Different Assesments in Individuals in Opioid Maintenance Treatment Process
Opioid use disorder is the chronic use of opioids that causes clinically significant distress or impairment. More than 16 million people world wide are opioid addicts.
- Trial name
- NCT05635682
- Testing
- Observational and anthropometric assesments
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gazi University
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
Opioid-use Disorder, Opioid-related Disorders
An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery
The RECOVER Study will examine clinical, environmental and socioeconomic factors in recovery from opioid use disorder (OUD) over a 24-month period following exit from a Phase III clinical program for a buprenorphine…
- Trial name
- RECOVER® (NCT03604861)
- Testing
- Not applicable - no defined intervention
- Where
- 35 sites in United States
- Volunteers
- 534 people
- Sponsor
- Indivior Inc.