Clinical trials: Opiate-Related Disorders
Opioid-use Disorder, Amphetamine Use Disorders
Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder
Chronic drug addiction is not only associated with increased mental health symptoms, such as anxiety and depression, but also with brain (neural and cognitive) deficits.
- Trial name
- NEAT (NCT03922646)
- Testing
- Neurocognitive Empowerment for Addiction Treatment (NEAT), Active Control
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Opioid-Related Disorders, Substance-Related Disorders
Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2
The purpose of this study is to evaluate the effect, pharmacokinetics and dose proportionality of buprenorphine when administered to non-dependent opiate users.
- Trial name
- NCT00015041
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, Drug Dependence
Treatment of Polydrug-Using Opiate Dependents During Withdrawal
Managed detoxification is a first and necessary step prior to treatment and rehabilitation. Detoxification can be a major obstacle for some patients, and the availability of managed and safe withdrawal is a prerequisite for…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00367874
- Testing
- Buprenorphine, Valproate
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Sorlandet Hospital HF
Opiate Dependence
Remote Observed Dosing to Increase Suboxone Compliance
The goal of this project is to test the feasibility, acceptability, and preliminary efficacy of using remote compliance monitoring in buprenorphine (Suboxone®) treatment for opiate dependence.
- Trial name
- RODISC (NCT01779973)
- Testing
- Remote Observed Dosing
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Opiate Dependence, Stimulant Dependence
Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia
To evaluate the tolerability, acceptability and potential effect size of the efficacy of 4 months of atomoxetine treatment for patients with co-occurring ATS and heroin dependence (COATS) receiving buprenorphine maintenance…
- Trial name
- NCT01863251
- Testing
- Atomoxetine
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- Yale University
Addiction Opiate, Chronic Pain
Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population
This is a randomized controlled trial. Patients will be randomly assigned to either the control or treatment group, with equal allocation using block randomization.
- Conditions
- Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
- Trial name
- SUPER-ERAS (NCT04464512)
- Testing
- Sufentanil
- Where
- United States
- Sponsor
- West Virginia University
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for inpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032955
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in United States
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Heroin Dependence, Opioid-Related Disorders
Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
The purpose of this study is to determine whether the opportunity to take free supplemental hydromorphone (HYD) influences drug seeking behavior in heroin dependent individuals.
- Trial name
- NCT00218309
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Disorder, Schizoaffective Disorder
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study.
- Conditions
- Bipolar Disorder, Schizoaffective Disorder, Manic Disorder, Mania
- Trial name
- NCT00431184
- Testing
- Pentazocine, Lorazepam
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mclean Hospital
Opiate Addiction
Examination of Cognitive Function in Patients Treated With Subutex
People who addicted to Heroin and other opiates suffer from a disease with approved genetic basis. It causes to a behavioral response as searching and using those drugs even though they know it causes severe damages as…
- Trial name
- NCT00687089
- Testing
- Sexual, cognitive functional tests and measurement weight
- Volunteers
- 60 people
- Sponsor
- BeerYaakov Mental Health Center
Opioid Use, Opioid-Related Disorders
Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)
Among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Withdrawal, Opioid Overdose
- Trial name
- SOONER (NCT04740099)
- Testing
- SOONER Video & Kit, Standard of Care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Opioid-Related Disorders, Substance-Related Disorders
Trial of Buprenorphine/Naloxone for Opiate Dependence - 2
The purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate dependence treatment.
- Trial name
- NCT00000353
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder
Treatment for Opiate Addiction: Prognostic fActors of Responsiveness to Maintenance Treatment
A global and integrative treatment of opioid-use disorders (OUD) with opiate maintenance therapy (OMT) and psychosocial interventions is recommended by all current guidelines.
- Trial name
- TOPAZE (NCT03729388)
- Testing
- Prognosis factor associated with good outcome.
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Opioid-Related Disorders
Evaluation of Lofexidine for Treatment of Opiate Withdrawal - 10
The purpose of this study is to assess the safety of lofexidine in the treatment of opiate-dependent individuals.
- Trial name
- NCT00000345
- Testing
- Lofexidine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Opiate Dependence
A Video-Based HCV Curriculum for Drug Users
The investigators hypothesize that a well-designed hepatitis C (HCV)video education curriculum for high-risk drug users will show measurable benefits in improving HCV testing, hepatitis A and B vaccinations, and HCV knowledge…
- Trial name
- NCT00241917
- Testing
- Hepatitis C educational video, Video
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Organization to Achieve Solutions in Substance Abuse (OASIS)
Post Operative Pain, Regional Anesthesia Morbidity
Does ESP Block Reduce Pain and Opiates Consumption After Surgery
The patients will be randomly assigned to standard therapy or standard therapy+ESP nerve block. After surgery pain level and narcotic consumption will be measured, and vital signs and side effects will bo monitored for up to 72…
- Conditions
- Post Operative Pain, Regional Anesthesia Morbidity, Opioid-Related Disorders, Chronic Pain
- Trial name
- NCT05512897
- Testing
- erector spinea plane block
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michael Dubilet MD