Clinical trials: Opiates
Opiate Withdrawal Syndrome
A Study of Oral Ibogaine in Opioid Withdrawal
Study DMX-IB 201 is a Phase 1/2a study of ibogaine consisting of an initial single ascending dose escalation stage to determine the maximum tolerated dose (MTD) or treat-to-target dose (TTD) in healthy volunteers, followed by a…
- Trial name
- NCT05029401
- Testing
- DMX-1002
- Where
- 2 sites in United Kingdom
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- atai Therapeutics, Inc.
Dialectical Behavior Therapy, Individual and Group Drug Counseling
DBT Compared to I/GDC for the Treatment of Opiate Addiction in Emotionally Dysregulated Patients. - 1
The purpose of this study is to examine the efficacy of DBT compared to a standard drug counseling approach for the treatment of opiate addiction and borderline personality disorder (BPD).
- Trial name
- NCT00218595
- Testing
- DBT, I/GDC
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Opiate Overdose, Opioid-Related Disorders
Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care
This clinical trial aims to evaluate the pilot implementation of a machine-learning (ML)-driven clinical decision support (CDS) tool designed to predict opioid overdose risk within the electronic health record (EHR) system at UF…
- Conditions
- Opiate Overdose, Opioid-Related Disorders, Narcotic-Related Disorders, Substance-related Disorders
- Trial name
- DEMONSTRATE (NCT06810076)
- Testing
- Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention
- Where
- United States
- Volunteers
- 674 people
- Sponsor
- University of Pittsburgh
Anxiety Disorders, Opiate Addiction
Study of Treatment for Opioid Dependence and Anxiety Disorders
Anxiety is highly prevalent among individuals with opioid dependence and confers greater risk for continued opioid use and poor treatment outcomes.
- Trial name
- NCT02252068
- Testing
- I-CBT, IDC
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Mclean Hospital
Opioid Dependence
The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid Dependence
In this 5-year study, the investigators propose to evaluate the separate and combined effects of the FDA-approved formulation of extended release naltrexone (Vivitrol®) and employment-based reinforcement of opiate abstinence in…
- Trial name
- NCT01556425
- Testing
- Vivitrol, Employment-based opiate abstinence reinforcement, Usual Care Control
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Johns Hopkins University
Opioid-Related Disorders, Heroin Dependence
Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers
The objective of this study is to determine whether aprepitant blocks the opiate reward system in non-dependent opiate abusers, indicating its potential as a safe, non-addictive first line therapy for early heroin abuse.
- Conditions
- Opioid-Related Disorders, Heroin Dependence, Substance-Related Disorders
- Trial name
- NCT00726960
- Testing
- aprepitant
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Hepatitis C, Transmission, Intravenous Drug Abuser
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
The principle is to propose dedicated monthly screening days bringing together the health personnel involved (hepatologist, addictologist, nurse in charge of the program, addictology nurse and social worker) and to propose…
- Conditions
- Hepatitis C, Transmission, Intravenous Drug Abuser, Addiction, Alcohol, Addiction Opiate
- Trial name
- SCANVIR (NCT05361603)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Opioid-Related Disorders, Dependency (Psychology)
Buspirone for Opioid Tapering
This is a pilot study to collect preliminary data to support a grant application. The goal of the study is to evaluate whether the Food and Drug Administration (FDA)-approved and generically-available medication buspirone reduces…
- Conditions
- Opioid-Related Disorders, Dependency (Psychology), Pain, Chronic, Opiate Withdrawal Syndrome
- Trial name
- NCT03521960
- Testing
- Buspirone oral capsule
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Opiate Withdrawal Syndrome
Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts
This is an open-label, randomized, 2-sequence, cross-over study evaluating the difference of efficacy between ear acupressure alone and ear acupressure plus electroacupuncture therapy both combined with methadone treatment…
- Trial name
- AAMTH (NCT03012373)
- Testing
- Ear acupressure alone, Electroacupuncture plus ear acupressure
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Lu-Tung Christian Hospital
Acute Pain, Pain
Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department
This study investigates the use of low doses of ketamine, along with opiate pain medication, is more effective at controlling the acute pain of patients in the emergency department than opiate pain medication alone.
- Trial name
- NCT02489630
- Testing
- Ketamine, Normal Saline, opiate analgesic
- Volunteers
- 116 people
- Sponsor
- Carilion Clinic
Opioid-Related Disorders, Opiate Addiction
A Survey to Eval the Relation Between Doctor/Pharmacy Shopping and Outcomes Suggestive of Misuse, Abuse and/or Diversion
To evaluate the reasons patients go to more than one prescriber or more than one pharmacy to obtain prescriptions opioids and assess whether the percentage of patients reporting misuse, abuse and/or diversion increases across…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02667158
- Testing
- Survey to Eval Relation between Shopping and Misuse, Abuse
- Volunteers
- 1,085 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Opioid Overdose, Opioid Use Disorder
Safety, Tolerability, and Pharmacokinetics of CSX-1004
This is a Phase 1a, randomized, double-blind, single ascending dose study, designed to assess the safety, tolerability, and PK of a single CSX-1004 injection, administered by IV infusion across a range of doses in healthy adult…
- Trial name
- NCT06005402
- Testing
- CSX-1004
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cessation Therapeutics, Inc.
Opiate Addiction
Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents
This study is designed to determine the relative effectiveness of buprenorphine/naloxone (Suboxone) pharmacotherapy versus naltrexone pharmacotherapy for treatment retention, relapse prevention and opioid craving reduction among…
- Trial name
- NCT01015066
- Testing
- Buprenorphine/naloxone, Naltrexone
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Thoracic, Pulmonary Disease
Gabapentin for the Reduction of Opiate Use Following Pulmonary Resection (GROUP Trial)
The aim of this study is to determine if the reduction in narcotic requirement following pulmonary resection with gabapentin is clinically significant when compared to the effect seen with placebo.
- Trial name
- NCT05100160
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Drug Addiction, Stimulant Dependence
CRAFT Behavior Therapy: Treatment Entry Component
This research compares the benefits of the original treatment, Community Reinforcement and Family Training (CRAFT), with the Treatment Entry Training (TEnT) component of CRAFT to determine if TEnt alone can produce the primary…
- Conditions
- Drug Addiction, Stimulant Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00842036
- Testing
- Community Reinforcement and Family Training, Treatment Entry Training, 12- step Al/Nar- Anon Facilitation
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Treatment Research Institute
Evaluation of Association Between Opiate Use and Biliary Dilation
Opiate Use and Biliary Dilation
We hope to better define the association between opiate use and biliary dilation, which was evident in our previous retrospective study.
- Trial name
- NCT03870347
- Testing
- Endoscopic ultrasound
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Opiate Addiction
NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction
The objective of this study is to determine whether the closely supervised provision of injectable, pharmaceutical-grade heroin (in combination with oral methadone) is more effective than methadone therapy alone in recruiting…
- Trial name
- NCT00175357
- Testing
- Methadone, Diamorphine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 192 people
- Sponsor
- University of British Columbia
Chronic Pain, Opioid Use
Neuroimaging of Opioid Phase (OPAL)
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and…
- Trial name
- OPAL (NCT05905419)
- Testing
- Opioid Phase
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid-Related Disorders, Substance-Related Disorders
Buprenorphine Maintenance for Opiate Dependence - 6
The purpose of this study is to determine the efficacy of buprenorphine as a substitution pharmacotherapy for opiate dependence.
- Trial name
- NCT00000357
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders, Substance-Related Disorders
Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 3
The purpose of this study is to determine the safety of lofexidine in the treatment of opiate withdrawal. Preliminary data will also be obtained to assess the ability of lofexidine to alleviate opiate withdrawal signs and…
- Trial name
- NCT00000354
- Testing
- Lofexidine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)