Clinical trials: Opiates
Analgesia, Epidural
Levobupivacaine for Epidural Analgesia in Labour
In a prospective randomised study involving primiparous women in spontaneous uncomplicated labour with cervical dilatation > 7 cm, epidural analgesia will be given with an initial volume of 20 mL anaesthetic solution, followed by…
- Trial name
- NCT00929682
- Testing
- Randomization between two referenced treatments
- Volunteers
- 136 people
- Sponsor
- University Hospital, Clermont-Ferrand
Opioids; Harmful Use
Piloting a Naloxone Intervention in Philadelphia
The escalating opioid overdose epidemic is one of the most serious public health problems confronting the U.S. Death due to drug overdose is a significant and rising cause of mortality and morbidity in Philadelphia.
- Trial name
- NCT03305497
- Testing
- Mobile Phone Application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Drexel University
Opiate Dependence
Clinical Efficacy and Serum Proteomic Profiling of Suan-Zao-Ren Tang for Sleep Disturbance During Methadone Maintenance
The purpose of this study is to evaluate the efficacy of Suan-Zao-Ren Tang in improving sleep quality, anxiety, depression, and heroin craving among methadone-maintained persons with sleep complaints.
- Trial name
- NCT01913418
- Testing
- Suan-Zao-Ren Tang
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University, Taiwan
Hip Injuries
Opiate Prescribing Guidelines Following Hip Arthroscopy
The purpose of the study is to determine if opiates are required to achieve appropriate analgesia after hip arthroscopy in outpatient surgery.
- Trial name
- NCT04169113
- Testing
- Group 1 - Opiate Tablets post Hip Arthroscopy, Group 2 - Opiate Tablets post Hip Arthroscopy
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Northwestern University
Thoracic, Pulmonary Disease
Gabapentin for the Reduction of Opiate Use Following Pulmonary Resection (GROUP Trial)
The aim of this study is to determine if the reduction in narcotic requirement following pulmonary resection with gabapentin is clinically significant when compared to the effect seen with placebo.
- Trial name
- NCT05100160
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Labour
Systematic Clonidine for Epidural Analgesia in Labour
In a prospective randomised study involving primiparous women in spontaneous uncomplicated labour with cervical dilatation < 5 cm, epidural analgesia will be given with an initial volume of 20 mL anaesthetic solution, followed by…
- Trial name
- NCT00983125
- Testing
- Clonidine
- Where
- France
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Opioid Dependence
Completion of OST - a Prospective Study
Only limited information on the process of completing long-term opiate substitution treatment (OST) with substances like methadone exist.
- Trial name
- NCT01722435
- Testing
- Opiate Substitution Treatment
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Healthy Volunteers
Generation of Biological Samples Positive to Hydromorphone for Anti-doping Control
Background: Hydromorphone (HM) is a semi-synthetic derivative of morphine used for pain control. Like other opiates, due to its high potential of abuse HM is included on the World Anti-Doping Agency (WADA) list of prohibited…
- Trial name
- HM (NCT04081376)
- Testing
- Hydromorphone Hydrochloride
- Where
- Spain
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Anterior Cruciate Ligament Injuries
Reduce Opiate Exposure With ACL Surgery
This is a randomized control trial to investigate the effectiveness of a multimodal opiate sparing analgesic regimen in controlling post-operative pain and potentially reduce post-operative opioid consumption in patients…
- Trial name
- NCT06561035
- Testing
- Opiate Sparing, Opiate Based
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Campbell Clinic
Opioid Withdrawal
Pregabalin for Opiate Withdrawal Syndrome
It is a single blind randomized symptom triggered study to assess efficacy and safety of pregablin combined with the symptom triggered treatment for opiate withdrawal syndrome vs.
- Trial name
- NCT03017430
- Testing
- Pregabalin, Clonidine, Doxylamin
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- St. Petersburg Bekhterev Research Psychoneurological Institute
Chronic Pain, Opiate Dependence
Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Effective control of chronic pain is a top priority in the United States, as approximately 10% of adults have severe chronic pain - most of which is chronic lower back pain (CLBP).
- Conditions
- Chronic Pain, Opiate Dependence, Lower Back Pain
- Trial name
- NCT03681769
- Testing
- iTBS to the left dlPFC, cTBS to the mPFC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Neonatal Abstinence Syndrome, Neonatal Opiate Withdrawal Syndrome
Buprenorphine Pharmacometric Open Label Research Study of Drug Exposure
Neonatal withdrawal syndrome is a series of signs and symptoms in infants exposed to opioids in utero. Buprenorphine has demonstrated a 40% reduction in length of pharmacologic treatment compared to oral morphine.
- Trial name
- B-PHORE (NCT03608696)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Opioid Overdose
Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics
Retrospective study to assess incidence and predictors of opioid abuse overdose and death associated with opioid overdose among patients prescribed opioid products in long-term use.
- Trial name
- NCT02662153
- Testing
- Observation only
- Where
- 4 sites in United States
- Volunteers
- 808,455 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Bunion of Unspecified Foot, Bunionette of Unspecified Foot
Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study
Orthopedic surgeons frequently prescribe and over-prescribe narcotic pain medications during the postoperative period, despite the ongoing opioid crisis in the United States.
- Conditions
- Bunion of Unspecified Foot, Bunionette of Unspecified Foot, Hammertoe, Ankle Fractures
- Trial name
- NCT04771741
- Testing
- Acetominophen, Toradol, Meloxicam
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Prisma Health-Midlands
Substance Dependence
Stress, Distress Intolerance, and Drug Dependence
This study is designed to evaluate the relative efficacy of a novel treatment (CBT-IC) versus a standard individual drug-counseling treatment.
- Trial name
- NCT00430482
- Testing
- Cognitive Behavioral Therapy, Individual Counseling
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- Boston University Charles River Campus
Opioid-Related Disorders
The OPT-IN Project
Prescription opioid overdose represents a public health crisis. A number of efforts have been implemented to address opioid prescribing and opioid risk mitigation strategies for prescribers, but relatively few efforts have sought…
- Trial name
- NCT03526380
- Testing
- Behavioral: the OPT-IN Intervention
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Michigan
Chronic Pain, Opiate Dependence
Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment
This study involves the comparison of two treatment approaches for patients with chronic pain who are entering methadone maintenance treatment (MMT) for opioid addiction: (a) an integrated counseling that addresses both chronic…
- Trial name
- NCT01334580
- Testing
- Cognitive-Behavioral Therapy for Pain and Opioid Dependence, Methadone Drug Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
HIV, Buprenorphine, and the Criminal Justice System (STRIDE2)
STRIDE2 is a longitudinal, non-randomized study of individuals living with HIV who are dependent on opioids. This study is funded by the National Institute on Drug Abuse (R01DA030768, Altice, PI; Taxman \& Lawson, Co-PIs) and is…
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- NCT03583138
- Testing
- buprenorphine
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Yale University
Opioid Overdose
Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults
This study will be a Phase 1, single-center, open-label, randomized cross-over study to evaluate the PK of a new AP003 device which delivers two sprays of 4 mg naloxone hydrochloride intranasally.
- Trial name
- NCT05377255
- Testing
- 16 mg naloxone AP003, 8 mg naloxone NARCAN Nasal Spray
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Opioid Overdose
Clinical Outcomes From Nalmefene
The purpose of this study is to assess the effectiveness of nalmefene relative to naloxone for the reversal of opioid intoxication in emergency department (ED) settings.
- Trial name
- COINED (NCT05808881)
- Testing
- Nalmefene Hydrochloride Injection, Naloxone Hydrochloride Injection
- Sponsor
- Purdue Pharma LP