Clinical trials: Opiates
Opiate Addiction
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
- Trial name
- NCT00879996
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Hypoglycemia
Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia
Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels.
- Trial name
- NCT01462227
- Testing
- Naltrexone High Dose, Naltrexone Low Dose
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Neonatal Abstinence Syndrome
NAS Treatment - Opiate Versus Non-Opiate
The purpose of this study is to compare two different medicines to treat babies with opiate withdrawal. The treatment medicines are morphine, which is an opiate, and clonidine, a non-opiate.
- Trial name
- NAS (NCT01734551)
- Testing
- Morphine, Clonidine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Henrietta Bada
Acute Pain, Pain
Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department
This study investigates the use of low doses of ketamine, along with opiate pain medication, is more effective at controlling the acute pain of patients in the emergency department than opiate pain medication alone.
- Trial name
- NCT02489630
- Testing
- Ketamine, Normal Saline, opiate analgesic
- Volunteers
- 116 people
- Sponsor
- Carilion Clinic
Opioid-Related Disorders, Substance-Related Disorders
Prescription Opioid Effects in Abusers Versus Non-Abusers
The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.
- Trial name
- NCT00158184
- Testing
- oxycodone 15 mg, oxycodone 30 mg
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Rotator Cuff Tear Arthropathy
Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder Functional Outcomes
This will be a randomized controlled trial to determine if postoperative ibuprofen after arthroscopic rotator cuff repair impacts postoperative opiate medication use, Visual Analog Scale (VAS) pain scores, shoulder range of…
- Trial name
- NCT02588027
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of California, San Francisco
Pain, Opiates
Preventing Risky Drinking in Veterans Treated With Prescription Opioids
Veterans who are taking prescription opioids for chronic pain and are engaging in risky drinking are at heightened risk for drug interactions, including overdose and other negative effects, particularly if they are also using…
- Conditions
- Pain, Opiates, Alcohol Drinking
- Trial name
- NCT02709317
- Testing
- Prevention Intervention, Brief Intervention
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Pennsylvania
Hepatitis C
Reaching mEthadone Users Attending Community pHarmacies With HCV
Hepatitis C Virus (HCV) is a blood-borne virus that damages the liver and is a major public health threat globally. Most individuals infected with HCV are unaware of it and show no symptoms until presenting with incurable, fatal…
- Trial name
- REACH-HCV (NCT03935906)
- Testing
- Reach Pathway, Education-only Pathway
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 1,410 people
- Sponsor
- University of Dundee
Opiate Dependence, Drug Dependence
A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED)
The purpose of this study is to assess the acceptability and safety of Suboxone in heroin users as a replacement therapy for opioid dependency by comparing the clinical response of participants who are inducted directly onto…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Dependence
- Trial name
- NCT00604188
- Testing
- Suboxone (SCH 000484), Subutex (SCH 028444)
- Volunteers
- 188 people
- Sponsor
- Merck Sharp & Dohme LLC
Opiate Dependence, Chronic Pain
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
This study is designed to develop an effective psychotherapy for chronic pain and opioid dependence.
- Trial name
- POD (NCT00634803)
- Testing
- CBT, Buprenorphine, Educational Counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Postoperative Pain, Opioid Use
A Randomized-controlled Trial of Post-operative Opiate Quantities After Urogynecologic Surgery
This is a randomized controlled trial to determine the effect of decreased post-operative prescriptions of opiate medications after urogynecologic surgery.
- Trial name
- NCT03319277
- Testing
- Decreased opiate prescription, Routine opiate prescription
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Opioid Use Disorder, Opioid Overdose
A Bundled Intervention
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge.
- Trial name
- B-CARE (NCT06593093)
- Testing
- a bundled intervention, including peer support specialist, buprenorphine, physician care, and telehealth
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Driving Behavior
Opiates and Benzodiazepines on Driving
The aim of this research is to assess drug effects (Xanax and Norco) on driving performance. Researchers will use the Alertness Memory Profiler (AMP) application to compare results to previous related studies.
- Trial name
- NCT03447353
- Testing
- Xanax 1Mg Tablet, Norco 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Timothy L. Brown
Opioid Overdose
Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program
The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has implemented Relay, a novel program that engages and intervenes with individuals in the ED following an opioid OD and for the next 90 days, with the goal…
- Trial name
- NCT04317053
- Testing
- RELAY
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- NYU Langone Health
Opioid Dependence
Memantine and Naltrexone Treatment for Opioid Dependence
The goal of this study is to test the efficacy of memantine (a noncompetitive NMDA receptor antagonist) as an adjunct to the maintenance treatment with naltrexone in detoxified heroin-dependent individuals.
- Trial name
- NAMHS-1 (NCT00125515)
- Testing
- Memantine, Naltrexone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Opiate Dependence, Heroin Dependence
Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot Naltrexone
In pilot study now proposed, we plan to randomly assign 60 opioid dependent patients to the new model, Depot-BNT, or to BNT plus oral naltrexone for a 6-month trial.
- Trial name
- Depot-BNT (NCT00577408)
- Testing
- depot naltrexone, Oral Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Anesthesia
Characterizing the Electroencephalogram Signature of Fentanyl During Induction of General Anesthesia
While historically anesthesiologists rely on pharmacokinetics to track the loss of consciousness, new research in anesthesiology has identified the salient features of the electroencephalogram (EEG) that correlate to states of…
- Trial name
- NCT03866278
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University