Clinical trials: Opioid Analgesia
Rectus Sheath Block, Transverse Abdominis Plane Block
Rectus Sheath Block Versus Transversus Abdominis Plane Block for Analgesia in Laparoscopic Bariatric Surgery
This randomized controlled trial aims to compare the analgesic efficacy of rectus sheath block (RSB) and transversus abdominis plane block (TAPB) in patients undergoing laparoscopic bariatric surgery.
- Conditions
- Rectus Sheath Block, Transverse Abdominis Plane Block, Opioid Consumption, Postoperative, Analgesia
- Trial name
- RSB-TAPB (NCT07592091)
- Testing
- Rectus Sheath Block, Transversus Abdominis Plane Block
- Where
- Thailand
- Volunteers
- 96 people
- Sponsor
- Chiang Mai University
Intensive Care (ICU), Respiratory Distress Syndrome (RDS)
Feasibility of Protocolised Analgosedation in ECMO
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care (ICU), Respiratory Distress Syndrome (RDS), Sedation and Analgesia, Extracorporeal Membrane Oxygenation
- Trial name
- ECMO-SED (NCT07580781)
- Testing
- Sedation protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Opioid Consumption, Postoperative, Pain, Postoperative
Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques
This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane block (L-ESP) groups to relieve postoperative pain in participants over…
- Conditions
- Opioid Consumption, Postoperative, Pain, Postoperative, Nerve Block, PENG Block
- Trial name
- NCT06821516
- Testing
- Evaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Postoperative Pain, Lumbar Surgery
Retrolaminar Analgesia for LuMbar Surgery
This randomized controlled trial evaluates the effectiveness of ultrasound-guided retrolaminar nerve block in addition to standard multimodal analgesia for postoperative pain management in patients undergoing lumbar spine…
- Conditions
- Postoperative Pain, Lumbar Surgery, Back Pain Lower Back Chronic, Opioid Analgesia
- Trial name
- REALM (NCT07334288)
- Testing
- Ultrasound-Guided Retrolaminar Block, Standard Analgesia
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Universidad de los Andes, Chile
Pain, Postoperative, Ankle Fracture Surgery
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very addictive.
- Conditions
- Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence
- Trial name
- BAFA (NCT06949826)
- Testing
- Buprenorphine Transdermal System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jenna-Leigh Wilson
Surgery, Pain Management
Comparison of the Efficacy and Safety of Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode of Intravenous PCA Following Mixed Surgery
Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications.
- Conditions
- Surgery, Pain Management, Opioid Consumption, Patient Controlled Analgesia
- Trial name
- NCT07375121
- Testing
- Fixed-rate basal infusion mode, Time-programmed decremental background infusion mode
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Beijing Tiantan Hospital
Ophthalmic Surgery, Postoperative Pain Management
Efficacy and Safety of Anrikefon for Postoperative Analgesia in Ophthalmic Surgery
The goal of this clinical trial is to learn if Anrikefon works as well as nalbuphine to control postoperative pain in adults undergoing ophthalmic surgery under general anesthesia.
- Conditions
- Ophthalmic Surgery, Postoperative Pain Management, Opioid Analgesia
- Trial name
- NCT07269106
- Testing
- Anrikefon, Nalbuphine
- Where
- 3 sites in China
- Volunteers
- 204 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Postoperative Pain Management, Analgesia, Postoperative
Superficial vs Deep Serratus Anterior Plane Block for Analgesia After Mammoplasty
The serratus anterior plane block (SAPB) is an ultrasound-guided fascial plane block used for perioperative analgesia in thoracic and breast surgeries.
- Conditions
- Postoperative Pain Management, Analgesia, Postoperative, Breast Surgery, Mammoplasty Patient
- Trial name
- DSAPvsSSAP (NCT07502846)
- Testing
- Superficial Serratus Anterior Plane Block, Deep Serratus Anterior Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pancreatoduodenectomy, Pain Management
Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy
The goal of this clinical trial is to determine whether continuous nefopam administration, as part of a multimodal analgesia strategy, reduces opioid consumption and improves patient satisfaction after pancreatoduodenectomy.
- Conditions
- Pancreatoduodenectomy, Pain Management, Opioid Analgesia, Multimodal Analgesia
- Trial name
- NCT07423650
- Testing
- Nefopam 120mg/day infusion, Lidocaine Infusion, Peridural
- Where
- Romania
- Volunteers
- 93 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia
Anterior QLB for PCNL
Aim: In this study, we primarily aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery…
- Conditions
- Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia, Quadratus Lumborum Block, Opioid Consumption
- Trial name
- NCT07487415
- Testing
- ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Zonguldak Bulent Ecevit University
Knee Arthroplasty, Postoperative Pain
Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty
This study is conducted to evaluate the effectiveness and safety of ketamine infusion for pain relief after knee replacement surgery.
- Conditions
- Knee Arthroplasty, Postoperative Pain, Pain Management, Analgesia
- Trial name
- KETARTHRO (NCT07059429)
- Testing
- Ketamine, Standard Analgesia
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Bariatric Sleeve Gastrectomy, Erector Spina Plan Block
Effect of Erector Spinae Plane Block on Postoperative Analgesia and Stress Response in Laparoscopic Sleeve Gastrectomy
Effective postoperative analgesia is an important component of enhanced recovery after bariatric surgery. The erector spinae plane block (ESPB) is a regional anesthesia technique that has been increasingly used in abdominal and…
- Conditions
- Bariatric Sleeve Gastrectomy, Erector Spina Plan Block, Cortisol, Numerical Rating Scale
- Trial name
- NCT07431905
- Testing
- Erector Spinae Plane Block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Post Operative Analgesia, Opioid Sparing Anaesthesia
To Compare Post-op Analgesic Effectiveness of Ropivicaine+Dexamethasone and Ropivacane+Dexmetomidine in TAP Block in Stoma Reversal Under GA in Terms of Duration of Analgesia.
Controlling pain is of major concern in intra-operative as well as post-operative period inpatients undergoing all surgeries especially abdominal surgeries.Adequate pain control in post-operative period directly effect patient's…
- Conditions
- Post Operative Analgesia, Opioid Sparing Anaesthesia, Hypotension, Controlled, Bradycardia
- Trial name
- NCT07368075
- Testing
- TAP Block with Ropivacaine+Dexamethasone, TAP Block with Ropivacaine+Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Postoperative Pain, Thoracic Surgery
Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery
Thoracic surgery often produces severe postoperative pain due to nerve injury and inflammation. Effective pain control is essential to reduce complications and opioid use.
- Conditions
- Postoperative Pain, Thoracic Surgery, Multimodal Analgesia, Opioid Consumption, Postoperative
- Trial name
- LKM-Thorax (NCT07359469)
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Universidad Pública de Navarra
Analgesia, Abuse Opioids
Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
The goal of this study is to compare the abuse potential of low-dose equianalgesic buccal buprenorphine to a commonly used full mu opioid receptor (MOR) agonist in a highly controlled experimental setting.
- Conditions
- Analgesia, Abuse Opioids, Pain
- Trial name
- NCT05988710
- Testing
- Buccal Buprenorphine 300 mcg, Buccal Buprenorphine 600 mcg, Buccal Buprenorphine 900 mcg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pruritis, Hypotension Drug-Induced
Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.
The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women.
- Conditions
- Pruritis, Hypotension Drug-Induced, Urinary Retention, Fetal Bradycardia During Labor
- Trial name
- NCT07187427
- Testing
- Spinal analgesia, Epidural Analgesia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Justine's Hospital
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Pain, Chronic Pain
Evaluation of an Opioid Stewardship Program in Non-Cancer Patients
The objective of this prospective, non-randomized clinical trial is to evaluate the effectiveness of a pharmacist-led Opioid Stewardship Program (OSP) in outpatient adults with chronic non-cancer pain.
- Conditions
- Pain, Chronic Pain, Opioid Analgesia, Opioid Use
- Trial name
- NCT07102446
- Testing
- Opioid Stewardship Program
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Korea University Guro Hospital