Clinical trials: Opioid Dependency
Breast Feeding, Opioid-Related Disorders
Methadone Levels in Breast Milk of Women Taking Methadone for Opiate Addiction - 2
Methadone is a drug that offers significant therapeutic benefits to opiate dependent women who are pregnant. Currently, it is the treatment of choice for this group of people.
- Trial name
- NCT00218010
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders
Buprenorphine Formulation Comparison: Sublingual Tablet vs. Solution - 1
The purpose of this study is to compare subject response to liquid vs. tablet formulations, to assess bioequivalency of liquid vs.
- Trial name
- NCT00000320
- Testing
- Buprenorphine formulation: liquid vs. tablet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Dependence, Opioid Abuse
A Pragmatic Trial of the Consult for Addiction Treatment and Care in Hospitals (CATCH) Model for Engaging Patients in Opioid Use Disorder Treatment
This pragmatic clinical trial seeks to evaluate the effectiveness of the Consult for Addiction Treatment and Care in Hospitals (CATCH) intervention as a strategy for engaging patients with Opiod Use Disorder (OUD) in addiction…
- Trial name
- CATCH (NCT03611335)
- Testing
- CATCH Interviews
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- NYU Langone Health
Chronic Pain, Opioid Use
Reducing Opioid Use for Chronic Pain Patients Following Surgery
Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use.
- Conditions
- Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
- Trial name
- RECOUP (NCT03675386)
- Testing
- Interventional Group, Control Intervention
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Opioid Dependence
Starting Treatment With Agonist Replacement Therapies Follow-up Study
The purpose of the study is to conduct a follow-up of substance abuse patients (n=1,269) about 2 to 5 years since they were originally recruited from 8 substance abuse treatment clinics (located in 5 states) to participate in a…
- Trial name
- NCT01592461
- Where
- 8 sites in United States
- Volunteers
- 877 people
- Sponsor
- University of California, Los Angeles
Opioid Dependence
A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing Opioid Agonist Hydromorphone
This study adopted a randomized, double-blind study design to evaluate the antagonistic effect, safety and pharmacokinetics of Naltrexone (opioid receptor antagonist) implantation after Hydromorphone (opioid receptor agonist)…
- Trial name
- NCT07014644
- Testing
- 1.5g Naltrexone Implant
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Shenzhen Sciencare Medical Industries Co., Ltd.
Cocaine-Related Disorders, Opiate Dependence
Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1
Many opioid-dependent individuals are also dependent on cocaine. Methadone is a widely used and effective method for treating opioid dependence. However, it is not effective in treating other drugs of abuse.
- Trial name
- NCT00129298
- Testing
- Tiagabine
- Volunteers
- 80 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence, HIV Infections
HIV Risk Reduction and Drug Abuse Treatment in Iran
A randomized, double blind clinical trial comparing buprenorphine and naltrexone maintenance treatment when combined with drug abuse and HIV risk reduction counseling (DC-HIV) for heroin and opium addicts in Iran.
- Trial name
- NCT00398008
- Testing
- Buprenorphine/Subutex, Naltrexone, Drug counseling
- Where
- 2 sites in United States, Iran
- Sponsor
- Yale University
Opiate Dependence
Acceptance Therapy During Methadone Detoxification
The purpose of this study is to develop an opiate detoxification behavior therapy based on current Acceptance and Commitment Therapy (ACT) theory and method, and to test its feasibility and promise in the context of voluntary…
- Trial name
- NCT00439036
- Testing
- Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Heroin Dependence
Variance of Oral Methadone Dosage: Description of Implicated Factors
The purpose of this study is to describe clinical, pharmacokinetic and genetic factors associated with the variance of oral methadone dosage for patients at the steady state of heroin dependence maintenance treatment.
- Trial name
- METHADOSE (NCT00894452)
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opiate Dependence, Drug Dependence
A Randomized Acceptability and Safety Study of the Transfer From Subutex to Suboxone in Opioid- Dependent Subjects (Study P04843)(COMPLETED)
Post-marketing commitment to the European Medicines Agency to conduct a prospective, controlled study of the transfer from Subutex to Suboxone.
- Trial name
- NCT00605033
- Testing
- Suboxone, Buprenorphine Hydrochloride + Naloxone, SCH 484, Subutex, Buprenorphine Hydrochloride, SCH 28444
- Volunteers
- 241 people
- Sponsor
- Indivior Inc.
Heroin Dependence
A Stepwise Strategy Utilizing Buprenorphine and Methadone
The objective of this study is to compare optimally given methadone maintenance treatment (MMT) for heroin dependence with a novel, sequential strategy, where patients are offered buprenorphine as first line treatment, allowed…
- Trial name
- NCT00310934
- Testing
- methadone, buprenorphine / methadone sequence, Relapse prevention
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Karolinska University Hospital
HIV Infections, Heroin Dependence
Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chennai, India
Though the HIV epidemic in India is predominantly among heterosexual populations, it is estimated that there are approximately 1.1 million injection drug users (IDUs) in India with HIV prevalence as high as 64% among IDUs in…
- Trial name
- DAART+ (NCT00709007)
- Testing
- Directly Administered Antiretroviral Therapy (DAART), SAT
- Where
- India
- Sponsor
- Johns Hopkins University
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cocaine-Related Disorder, Opiate Dependence
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
This 18-week, randomized, double blind clinical trial provided treatment for 160 cocaine-dependent opioid addicts, aged 18-65 years.
- Trial name
- NCT00580827
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Yale University
Heroin Dependence, Opiate Dependence
Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction
The planned research will adapt an intervention of known efficacy to target a new outcome of significant importance to public health.
- Conditions
- Heroin Dependence, Opiate Dependence, Substance Dependence
- Trial name
- NCT00609089
- Testing
- CRAFT-T, Treatment as usual
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Pain
Neuropsychoanalytic Treatment of Failed Back Surgery Syndrome-Opioid Dependence
Opioid Dependent Patients who have failed back surgery syndrome are detoxified and treated with a neuropsychoanalytic paradigm.
- Trial name
- NCT01940588
- Testing
- Neuropsychoanalytic therapy
- Volunteers
- 30 people
- Sponsor
- State University of New York - Upstate Medical University
Opioid-use Disorder, Opioid Use, Unspecified
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution…
- Conditions
- Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
- Trial name
- Mother/BabyOUD (NCT03923374)
- Testing
- Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid Dependence, Chronic Pain
Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pain
This study aims to investigate the feasibility and preliminary efficacy of an enhanced opioid stewardship program, tailored to the needs of hospitalized patients with chronic pain with opioid dependence, incorporating real-time…
- Trial name
- NCT05370326
- Testing
- Enhanced Opioid Stewardship Program
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Yale University
Heroin Dependence
Effect Study of Optimized Intervention to Heroin Addicts
The purpose of this study is to explore barriers and determine whether optimizing protocol is effective in the treatment of heroin dependence in community-based MMT clinics.
- Trial name
- NCT01144390
- Testing
- cognitive behavioral therapy, methadone maintenance treatment
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Mental Health Center