Clinical trials: Opioid Free Anesthesia
Cancer, Bladder
Opioid Free Anesthesia in Prolonged Surgery
this study is designed to compare intrathecal bolus of bupivacaine-dexmedetomidine versus continuous epidural fentanyl infusion in providing effective operative analgesia, intraoperative hemodynamic stability and less…
- Trial name
- NCT05262166
- Testing
- INTRATHECAL dexmedetomidine INJECTION
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mansoura University
Postoperative Nausea and Vomiting, Opioid Use
Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery
This study aimed to verify whether an Opioid-free Anesthesia (OFA) could effectively reduce the incidence of PONV after thoracoscopic-assisted surgery compared with standard general anesthesia (OA) regimens.
- Conditions
- Postoperative Nausea and Vomiting, Opioid Use, Thoracic Diseases
- Trial name
- OFA-PONV (NCT05411159)
- Testing
- Opioid-Free Anesthesia (OFA), Standard general anesthesia (OA)
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Beijing Chao Yang Hospital
Supratentorial Tumors
Opioid-free Anesthesia Protocol for Neurosurgical Supratentorial Tumor Resection
Opioids have many side effects, such as constipation, urinary retention, itchy skin, respiratory depression, and postoperative nausea and vomiting.
- Trial name
- NCT06607029
- Testing
- the opioid-based control group, the opioid-free anesthesia group
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Beijing Tiantan Hospital
Supra-tentorial Tumor
A Comparative Study Between Opioids Free Anesthesia and Opioid Anesthesia in Patients With Supratentorial Tumor Resection
Anesthesia for cranial surgeries is charactarized by periods of unpleasant stimuli interspersed with periods of low stimulation, which may compromise hemodynamic regulation.
- Trial name
- NCT06791811
- Testing
- OFA, OA
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Kasr El Aini Hospital
Opioid Free Anesthesia
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery
Patients undergoing nephrectomy have a high incidence of postoperative pain. In the perioperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both.
- Trial name
- NCT05312541
- Testing
- pre emptive local anaesthetic wound infiltration
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Post Operative Recovery, Post Operative Nausea and Vomiting (PONV)
A COMPARATIVE STUDY BETWEEN OPIOID-FREE GENERAL ANAESTHESIA AND OPIOID-BASED GENERAL ANAESTHESIA ON THE QUALITY OF RECOVERY IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC HYSTRECTOMY: A Randomized Trial
the intent of this study To compare the efficacy of opioid free general anaesthesia versus opioid based general anaesthesia to achieve enhanced recovery regarding post-operative pain and post-operative nausea and vomiting…
- Conditions
- Post Operative Recovery, Post Operative Nausea and Vomiting (PONV), Post Operative Analgesia
- Trial name
- NCT07739641
- Testing
- Fentanyl-Based Anesthesia, Opioid-Free Anaesthesia (Dexmedetomidine, Ketamine, and Lidocaine)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Opioid Free Anaesthesia, Postoperative Analgesia
Opioid vs. Opioid-free Anesthesia for Hip Arthroscopy
The purpose of this study is to determine whether an infusion of lidocaine/ketamine compared to fentanyl is equivalent in anesthesia effectiveness and can help reduce the incidence of postoperative nausea and vomiting in patients…
- Trial name
- NCT02150161
- Testing
- Lidocaine/ ketamine, Fentanyl
- Where
- Chile
- Volunteers
- 53 people
- Sponsor
- Clinica Santa Maria
Cognitive Dysfunction, Opioid Free Anesthesia
Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries
In this study, the patients undergoing pituitary surgery in our clinic have examined in two groups. In the first group, anesthesia maintenance was provided with remifentanil and propofol infusion.
- Trial name
- NCT06793150
- Testing
- Remifentanil, dexmedetomidin
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kocaeli University
Inflammation, Postoperative Pain
Impact of Suppressing Surgical Stress Reaction on Postoperative Inflammation.
Patients undergoing surgery under opioid free general anesthesia (OFA) are monitored with antinociceptive devices like NOL or ANI that measures sympathetic activity but are invisible for the attending anesthesiologist .
- Trial name
- NCT04195009
- Testing
- major surgery under opioid free anesthesia without regional anesthesia
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- AZ Sint-Jan AV
Anesthesia
Melatonin in Obese Patients in Laparoscopic Cholecystectomy
Opioid free anesthesia (OFA) means a technique in which no intraoperative opioid is administered through any route. Perioperative pain management in an obese patient is challenging.
- Trial name
- NCT06355687
- Testing
- Melatonin, Vitamin Supplement
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Analgesics，Opioid, Bariatric Surgery
Multimodal Analgesic Management of Naborphine Combined With Opioid Free Anesthesia in OSA Patients Undergoing Bariatric Surgery
Comparative study to explore the effect of opioid free anesthesia technology in perioperative analgesia management, clarify the effect of naborphine instead of opioids on perioperative analgesia management in morbid obesity…
- Trial name
- NCT05386979
- Testing
- Opioid free anesthesia technology
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Video-assisted Thoracoscopic Lung Surgery；Anesthesia
Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS
Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery.
- Trial name
- NCT06367218
- Testing
- opioid based strategy, opioid-free strategy, Laryngeal mask airway; Preserved spontaneous breathing
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Tongji Hospital
Decreased Lung Compliance, Oxygen Requirement
Impact of OFA During LPV on Postoperative Oxygen Saturation
Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung…
- Trial name
- NCT03660306
- Testing
- opioid anesthesia, opioid free anesthesia
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- AZ Sint-Jan AV
Retrolaminar Block, Erector Spinae Plane Block
Retrolaminar Block Versus Erector Spinae Plane Block as Opioid-Free Anesthesia for Enhanced Recovery After Posterior Lumbar Discectomy
The aim of this study is to compare retrolaminar block and erector spine plane block as opioid-free anesthesia for enhanced recovery after posterior lumbar discectomy.
- Conditions
- Retrolaminar Block, Erector Spinae Plane Block, Opioid-Free Anesthesia, Enhanced Recovery
- Trial name
- NCT06725680
- Testing
- Retrolaminar block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Breast Cancer
Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.
This study will compare morphine consumption during the first 48 hours postoperatively between the OFA group and the CA control group.
- Trial name
- OFOBA (NCT05439005)
- Testing
- Dexmedetomidine
- Where
- 3 sites in France
- Volunteers
- 158 people
- Sponsor
- Institut Curie
Breast Cancer, Mastectomy
A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia
In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain.
- Conditions
- Breast Cancer, Mastectomy, Pain, Chronic, Pain, Post Operative
- Trial name
- RELIEF (NCT05146778)
- Testing
- Opioid-free anesthesia, Conventional opioid-based anesthesia
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Gangnam Severance Hospital
Pain, Pain Management
Evaluating The Efficacy Of Pecs II Blockade Compared To Local Anesthetic Infiltration In Controlling Postoperative Pain In Patients Undergoing Oncologic Breast Surgery Under Opioid Free/Sparing Anesthesia.
Breast cancer is the malignant neoplasm with the highest incidence in women in Brazil, with the exception of non-melanoma skin tumors.
- Conditions
- Pain, Pain Management, Anesthesia
- Trial name
- pain (NCT06889870)
- Testing
- Pectoral Nerve Block, Local Anesthesia
- Where
- Brazil
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Severe Obesity
Non-opioid Anesthesia in Bariatric Surgery
Opioid-free anesthesia is a new approach to anesthesia, described and used for many years. If it represents many advantages by reducing the side effects of morphine, its precise place in current practice and in terms of…
- Trial name
- BARIA (NCT06162416)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France