Clinical trials: Opioid Misuse
Chronic Pain, Opioid Misuse
French Version of POMI Scale
French translation and validation of the Prescription Opioid Misuse Index scale (POMI), a brief questionnaire to assess opioid prescription misuse.
- Trial name
- POMI (NCT04979364)
- Volunteers
- 154 people
- Sponsor
- University Hospital, Clermont-Ferrand
Substance Use Disorders, Treatment Adherence and Compliance
Kentucky Access to Recovery Evaluation
Evaluate the long-term effectiveness of implementing vouchers as a linkage strategy in a population requiring recovery support services (RSS) when no other funding sources are available.
- Trial name
- NCT05889702
- Testing
- KATR Linkage Strategy
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Terry Bunn
Opioid Prescribing, Prescription Drug Misuse
E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs
This study will test e-mails to encourage engagement with the Minnesota prescription monitoring program (PMP/PDMP) and will evaluate the effect of these e-mails on PMP/PDMP use and controlled substance prescribing.
- Trial name
- NCT06443385
- Testing
- PDMP Legal Mandate E-mail, PDMP Clinical Benefit E-mail
- Where
- United States
- Volunteers
- 7,872 people, healthy volunteers welcome
- Sponsor
- Columbia University
Overdose, Opioid Use Disorder
Community-based Education, Navigation, and Support Intervention for Military Veterans
Military veterans in the U.S. represent one of the populations most disproportionately impacted by the current opioid crisis. Veterans who use opioids and are not connected to the VA healthcare system have high rates of…
- Conditions
- Overdose, Opioid Use Disorder, HIV Infections
- Trial name
- CENS (NCT05343169)
- Testing
- Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York University
Opioid Misuse, Chronic Pain
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
The NIH Helping to End Addiction Long-term (HEAL) initiative has identified a critical next step to addressing the opioid crisis: improving treatments for opioid misuse behaviors (e.g., using more opioids than prescribed, illicit…
- Trial name
- NCT05182606
- Testing
- Pilot study of algorithms implementation package
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Motivation, Drug Effect
How Stress Alters Opioid Drug Effects
The main objective of the study is to test the hypothesis that opioid drug effects vary as a function of pre-drug affective state.
- Conditions
- Motivation, Drug Effect, Stress Reaction, Misuse, Opioid
- Trial name
- OPIOIDREWARD (NCT06485817)
- Testing
- Oxycodone, Stress State Induction, Control State Induction
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid-Related Disorders, Opiate Addiction
A Qualitative Study to Assess the Content Validity of the Prescription Opioid Misuse and Abuse Questionnaire
The purpose of this study is to evaluate the patient usability and reliability of the POMAQ survey to evaluate opioid misuse and abuse among adults with chronic moderate to severe pain, including patients who are opioid abusers…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- POMAQ (NCT02660606)
- Testing
- Prescription Opioid Misuse and Abuse Questionnaire (POMAQ)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Drug Use, Substance Use
Organization-level Youth Engagement Approach for Substance Misuse Prevention
This study will consist of a small pilot Randomized Controlled Trial (RCT). Four prevention organizations will be randomized either to include Youth Engagement in prevention efforts (treatment) or not (control).
- Conditions
- Drug Use, Substance Use, Opioid Use, Substance Misuse
- Trial name
- NCT05736211
- Testing
- Organization-level Youth Engagement prevention strategy
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Chronic Pain, Opioid Misuse
Integrative Psychosocial Group Treatment
A fundamental challenge for healthcare is to achieve a balance between decreasing the misuse of opioids and associated harms while optimizing patient care, including the provision of multidisciplinary treatments for chronic pain.
- Trial name
- NCT03648177
- Testing
- IPGT, Treatment as Usual
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Overdose Risk, Opioid Use Disorder
Kentucky Women's Justice Community Overdose Innovation Network - Phase II
This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of reducing overdose risk during the transition from jail to rural…
- Conditions
- Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
- Trial name
- WJCOIN-II (NCT07179614)
- Testing
- Overdose Prevention Intervention Package (OPIP)
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Opioid Use, Opioid-Related Disorders
Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)
Among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Withdrawal, Opioid Overdose
- Trial name
- SOONER (NCT04740099)
- Testing
- SOONER Video & Kit, Standard of Care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Heart Arrest, Out-Of-Hospital, Opioid Overdose
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs.
- Conditions
- Heart Arrest, Out-Of-Hospital, Opioid Overdose, Naloxone
- Trial name
- NOPACA (NCT06251609)
- Testing
- Naloxone 2 MG, Saline 2ml
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Francisco
Pain, Substance Use
M2VA Pain Care Pathway
The goal of this 2-cohort, cluster randomized, type 2 hybrid trial is to test the effectiveness, cost-effectiveness and patient-level effects of an implementation facilitation strategy in helping M2VA case managers adopt a…
- Conditions
- Pain, Substance Use, Opioid Misuse, Quality of Life
- Trial name
- M2VAPCP (NCT06526143)
- Testing
- M2VA Pain Care Pathway (M2VAPCP), Implementation Facilitation
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- Yale University
Chronic Pain, Opioid Misuse
Mobile & Online-Based Interventions to Lessen Pain
The investigators will implement an international 2-arm online pragmatic feasibility randomized controlled trial (RCT) of a digital pain relief skills intervention "Empowered Relief: On-Demand" to reduce pain metrics, opioid…
- Conditions
- Chronic Pain, Opioid Misuse, Opioid Use Disorder
- Trial name
- NCT05152134
- Testing
- Empowered Relief On-Demand, Health Education
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Stanford University
Overdose, Risk Behavior
The Impact of Co-Dispensing Naloxone to Patients Prescribed Chronic Opioid Therapy
In the setting of naloxone standing orders, this study will assess if co-dispensing naloxone with opioids to patients prescribed chronic opioid therapy changes opioid risk behaviors, increases naloxone uptake, and increases…
- Trial name
- NCT03337100
- Testing
- Co-Dispensing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Kaiser Permanente
Pain, Chronic, Opioid Use
Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use
This is a single site, two-arm, parallel group randomized clinical trial comparing the effect of two mindfulness-based interventions (Mindful Interoceptive Mapping vs.
- Trial name
- NCT04523766
- Testing
- Mindfulness of Breath, Mindful Interoceptive Mapping
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- University of Utah
Opioid Misuse
Decreasing Opioid Misuse and Habit-forming Behaviors Following Prescription in Patients Undergoing Cesarean Section
Background: Cesarean delivery is one of the most common obstetric procedures experienced among women who are pregnant.1 Women with Cesarean deliveries have a higher rate of peripartum opioid prescriptions and persistent opioid…
- Trial name
- NCT05461196
- Testing
- CPMRx
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jessica Morgan
Drug Prescriptions
Effect of an Opioid Disposal Pouch Versus Usual Care on Post Discharge Disposal of Unused Medication
The purpose of the study is to determine if opioid disposal bags/pouches are an effective method for disposing of unused opioid medications postoperatively
- Trial name
- NCT04553588
- Testing
- Disposal pouch
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- The Cleveland Clinic
Pain, Postoperative, Opioid Misuse
Reduced Opioid Prescription After Laparoscopic Hysterectomy
Given the nationwide epidemic of opioid use and abuse (in part due to over prescription), this study aims at addressing the need for opioid prescription after laparoscopic hysterectomy.
- Conditions
- Pain, Postoperative, Opioid Misuse, Opioid Use, Pain
- Trial name
- NCT05548582
- Testing
- OxyCODONE 5 mg Oral Tablet, Acetaminophen 500 mg Tab, Ibuprofen 600 mg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University