Clinical trials: Opioid Overdose
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain, Postoperative, Opioid Use
Influence of Aging on Perioperative Methadone Dosing
Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid for perioperative pain management, however, to date there are no pharmacokinetic or pharmacodynamic studies that asses a methadone dose…
- Conditions
- Pain, Postoperative, Opioid Use, Methadone Overdose of Undetermined Intent
- Trial name
- NCT04526236
- Testing
- Methadone Injectable Product
- Where
- Chile
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Opioid Use Disorder, Opioid Use
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical…
- Trial name
- NCT06768814
- Testing
- Sub-acute stabilization
- Where
- United States
- Volunteers
- 40,000 people
- Sponsor
- University of Washington
Morphinan Opioid Overdose
Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
- Trial name
- NCT01293058
- Testing
- Intranasal naloxone, Intravenous
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Substance Use Disorders, Treatment Adherence and Compliance
Kentucky Access to Recovery Evaluation
Evaluate the long-term effectiveness of implementing vouchers as a linkage strategy in a population requiring recovery support services (RSS) when no other funding sources are available.
- Trial name
- NCT05889702
- Testing
- KATR Linkage Strategy
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Terry Bunn
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Overdose, Opioid Use Disorder
Community-based Education, Navigation, and Support Intervention for Military Veterans
Military veterans in the U.S. represent one of the populations most disproportionately impacted by the current opioid crisis. Veterans who use opioids and are not connected to the VA healthcare system have high rates of…
- Conditions
- Overdose, Opioid Use Disorder, HIV Infections
- Trial name
- CENS (NCT05343169)
- Testing
- Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- New York University
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Opioid Dependence, Opioid Use Disorder
Increasing Patient Knowledge of the Signs of Opioid Overdose and Naloxone in a Suburban Treatment Program
The purpose of this study is to determine the effect that an educational intervention has on patient knowledge of the signs of opioid overdose and appropriate use of naloxone in a suburban outpatient treatment program.
- Trial name
- NCT02120612
- Testing
- Naloxone Education Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Edward Hospital
Burnout, Compassion Satisfaction
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R61 Phase Pilot)
The investigators propose to develop and test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose…
- Conditions
- Burnout, Compassion Satisfaction, Secondary Trauma
- Trial name
- NCT07218562
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Chestnut Health Systems
Opioid Dependence
Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway
Persons dependent on opioids like heroin, morphine, or codeine have a high risk of relapse, overdose and overdose death. This risk is elevated even further following discharge from treatment or correctional institutions where…
- Trial name
- NTX-SBX (NCT01717963)
- Testing
- Naltrexone intramuscular suspension, Buprenorphine-naloxone
- Where
- 5 sites in Norway
- Volunteers
- 166 people
- Sponsor
- University of Oslo
Overdose Risk, Opioid Use Disorder
Kentucky Women's Justice Community Overdose Innovation Network - Phase II
This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of reducing overdose risk during the transition from jail to rural…
- Conditions
- Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
- Trial name
- WJCOIN-II (NCT07179614)
- Testing
- Overdose Prevention Intervention Package (OPIP)
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Opioid Use, Opioid-Related Disorders
Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)
Among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Withdrawal, Opioid Overdose
- Trial name
- SOONER (NCT04740099)
- Testing
- SOONER Video & Kit, Standard of Care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Heart Arrest, Out-Of-Hospital, Opioid Overdose
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs.
- Conditions
- Heart Arrest, Out-Of-Hospital, Opioid Overdose, Naloxone
- Trial name
- NOPACA (NCT06251609)
- Testing
- Naloxone 2 MG, Saline 2ml
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Francisco
Homelessness, Opioid Education and Naloxone Distribution (OEND)
Homeless Overdose Prevention- Expansion
Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in…
- Conditions
- Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
- Trial name
- HOPE (NCT07716202)
- Testing
- Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- VA Office of Research and Development
Overdose, Risk Behavior
The Impact of Co-Dispensing Naloxone to Patients Prescribed Chronic Opioid Therapy
In the setting of naloxone standing orders, this study will assess if co-dispensing naloxone with opioids to patients prescribed chronic opioid therapy changes opioid risk behaviors, increases naloxone uptake, and increases…
- Trial name
- NCT03337100
- Testing
- Co-Dispensing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Kaiser Permanente
Overdose, Implementation as Usual
Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone)
The goal of this clinical trial is to compare the effectiveness of a multi-faceted implementation strategy, the Systems Analysis and Improvement Approach for Naloxone (SAIA-N), in syringe service programs (SSPs).
- Trial name
- SAIA-N (NCT05886712)
- Testing
- Naloxone, Usual intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- RTI International
Substance Use Disorder (SUD), Opioid Use Disorder
Disease Intervention Specialist (DIS) for SUD
This prospective observational study evaluates three Disease Intervention Specialist service models designed to proactively identify and support adults at risk for substance use disorder.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorder, Alcohol Use Disorder (AUD), Drug Use
- Trial name
- DIS-SUD (NCT07875361)
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Ohio State University
Opioid-related Disorders, Opioid Addiction
ER/LA Opioid Surveillance for Emergency Department Visits and Hospitalizations for Overdose and Poisoning
Study to evaluate the impact of the ER/LA opioid REMS program on the incidence of Emergency Department visits and hospitalizations for overdose/poisoning and death among patients prescribed ER/LA opioid analgesics.
- Conditions
- Opioid-related Disorders, Opioid Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02866266
- Testing
- Retrospective database review
- Volunteers
- 183,452 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)