Clinical trials: Opioid Pain Medication
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Chronic Pain
A Study to Assess the Safety and Effectiveness of Durogesic (Fentanyl Transdermal Patch) in the Treatment of Children With Chronic Pain Requiring Long-term Narcotic Pain Relief Therapy
The purpose of this study is to assess the effectiveness and safety of Durogesic® (a transdermal patch delivering the narcotic pain-reliever fentanyl) in the treatment of children with chronic pain requiring long-term narcotic…
- Trial name
- NCT00271453
- Testing
- Durogesic® (fentanyl transdermal drug delivery system)
- Volunteers
- 41 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis, Arthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, Compared With Placebo in Patients With Osteoarthritis
The purpose of the study is to determine if fentanyl, delivered through the skin via an adhesive patch, has a superior pain-relieving effect compared with placebo in patients with osteoarthritis pain that is inadequately…
- Trial name
- NCT00236366
- Testing
- fentanyl
- Volunteers
- 418 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Hip Fractures
Regional Anesthesia by PENG-Block in Emergency Department
The study is a single-centre, open-label randomized comparative trial. Adult patients admitted to the emergency department for a hip fracture will be enrolled.
- Trial name
- ED-PENGBLOCK (NCT05673486)
- Testing
- PENG Block, Multimodal analgesia
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Surgical Procedure, Unspecified, Orthopedic Disorder
Opioid Consumption After Knee Arthroscopy
This is a prospective, randomized trial of patients undergoing outpatient knee arthroscopy surgery and receiving a peripheral nerve block.
- Trial name
- NCT03299920
- Testing
- Standardized instructions, Conventional instructions
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Giorgio Veneziano
Tooth Extraction
De-Implementing Opioids for Dental Extractions
The overarching goal of this project is to de-implement the reliance on opioid analgesics and to implement reliance on non-opioid analgesics to manage postoperative pain following dental extractions.
- Trial name
- DIODE (NCT03584789)
- Testing
- Clinical Decision Support, Patient education
- Where
- United States
- Volunteers
- 5,722 people
- Sponsor
- HealthPartners Institute
Pain, Post Operative, Pain, Acute
Opioid-free Anesthesia in Thyroidectomies
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective thyroidectomies.
- Conditions
- Pain, Post Operative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT05243940
- Testing
- dexmedetomidine-ketamine-lidocaine (DKL), remifentanil infusion
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Analgesia
Study of Post-Herniorrhaphy Non-opioid MMA Regimens
This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal…
- Trial name
- NCT03907176
- Testing
- HTX-011, Luer lock applicator, Ibuprofen
- Where
- 30 sites in United States
- Volunteers
- 209 people
- Sponsor
- Heron Therapeutics
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Inappropriate Dose of Drug Administered, Pain, Chronic
Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population
To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.
- Conditions
- Inappropriate Dose of Drug Administered, Pain, Chronic, Health Behavior
- Trial name
- TAPERING (NCT03400384)
- Testing
- Direct-to-consumer educational brochure
- Where
- Canada
- Volunteers
- 4,255 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
Prescription Drug Abuse
Using m-Health Tools to Reduce the Misuse of Opioid Pain Relievers
The aim of this study is to pilot test a web-based, patient-centered educational program that encourages the patient to have an informed discussion about pain medication options with their emergency department (ED) provider.
- Trial name
- NCT03012087
- Testing
- MyHealthyChoices, Health Risk Assessment
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pain, Postoperative, Analgesic Effect
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty is a commonly performed orthopaedic surgery for the treatment of end-stage osteoarthritis when conservative management becomes ineffective.
- Conditions
- Pain, Postoperative, Analgesic Effect, Total Knee Arthroplasty, Liposomal Bupivacaine
- Trial name
- NCT06740214
- Testing
- 0.5% standard bupivacaine only, 1.33% liposomal bupivacaine with 0.5% standard bupivacaine, 1.33% liposomal bupivacaine only
- Where
- Hong Kong
- Volunteers
- 177 people
- Sponsor
- The University of Hong Kong
Rotator Cuff Tear, Rotator Cuff Injury
Buprenorphine Transdermal Patches in Arthroscopic Rotator Cuff Repair
Arthroscopic rotator cuff repair is associated with poor post-operative pain management. The multimodal analgesic scheme (oral non-steroidal anti-inflammatory drugs associated with oral opioids) currently used according to the…
- Conditions
- Rotator Cuff Tear, Rotator Cuff Injury, Analgesics, Opioid, Buprenorphine
- Trial name
- NCT03380533
- Testing
- Buprenorphine, Multimodal Oral Scheme, Tramadol
- Where
- Argentina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Colo-rectal Cancer
Does Omission of NSAIDs After Colorectal Cancer Operation Affect the Consumption of Opioids?
Patients undergoing an operation for colorectal cancer are normally treated with non-steroid-anti-inflammatory-drugs (NSAIDs) e.g. ibuprofen as pain medication after the operation.
- Trial name
- NCT04448652
- Testing
- NSAID
- Where
- Denmark
- Volunteers
- 502 people
- Sponsor
- Zealand University Hospital
Opioid Dependence
Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- NCT00447564
- Testing
- Probuphine
- Where
- 18 sites in United States
- Volunteers
- 163 people
- Sponsor
- Titan Pharmaceuticals
Pain, Postoperative, Pain Uterus
Effects of Tapentadol Versus Oxycodone After Hysterectomy.
Opioids remain the first-line drugs for the treatment of moderate to severe postoperative pain, but the use is limited by well-known side-effects, most of which are dose-dependent.
- Conditions
- Pain, Postoperative, Pain Uterus, Pain, Acute, Opioid Use
- Trial name
- NCT03314792
- Testing
- Tapentadol, Oxycodone
- Where
- Norway
- Volunteers
- 86 people
- Sponsor
- Oslo University Hospital