Clinical trials: Opioid Pain Medication
Breast Cancer, Analgesia
U/S Guided Transversus Thoracic and Pectoral Nerve Block Versus Pectoral Nerve Block in MRM
Interfascial blocks score over regional anesthetic techniques such as Transversus Thoracic Plane Block and Pectoral Nerves (PECS) Block as they have no risk of sympathetic blockade, intrathecal or epidural spread, which may lead…
- Trial name
- NCT06371625
- Testing
- Transeversus Thoracic Plane Block (TTPB) and Pectoral Nerves (PECS) Block, Pectoral Nerves (PECS) Block
- Where
- 3 sites in Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Soliman
Surgical Procedure, Unspecified, Orthopedic Disorder
Opioid Consumption After Knee Arthroscopy
This is a prospective, randomized trial of patients undergoing outpatient knee arthroscopy surgery and receiving a peripheral nerve block.
- Trial name
- NCT03299920
- Testing
- Standardized instructions, Conventional instructions
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Giorgio Veneziano
Opioid Dependence
A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence
This study will measure the amount of buprenorphine found in the blood after taking sublingual buprenorphine tablets versus after implantation with 4 Probuphine (buprenorphine implants).
- Trial name
- PRO-810 (NCT00768482)
- Testing
- Probuphine (buprenorphine implant), Sublingual Buprenorphine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Titan Pharmaceuticals
Pain, Postoperative
Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?
With Institutional ethics board and Health Canada approval, pediatric patients (ages 3-12) undergoing tonsillectomy or adenotonsillectomy (under standardized anesthesia) will be randomized to receive dextromethorphan hydrobromide…
- Trial name
- NCT02727491
- Testing
- Dextromethorphan
- Volunteers
- 85 people
- Sponsor
- Dr. Rachel Rooney
Fractures, Closed, Pain, Postoperative
Pain and Narcotic Usage After Orthopaedic Surgery
This study aims to 1) observe the course of pain, 2) utilization of opioid pain medication, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients undergoing…
- Conditions
- Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute
- Trial name
- NCT03991546
- Testing
- Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Christopher Anthony
Opioid Use, Postoperative Pain
Analgesic Effects of Intrathecal Morphine and Bilateral Erector Spina Plane Block in Elective Cesarean Section
Cesarean section cause severe pain due to surgical incision, abdominal wall retraction and visceral organ movements. Cesarean section can be performed with general anesthesia, spinal anesthesia, epidural anesthesia and combined…
- Trial name
- NCT05698927
- Testing
- Erector Spinae Plane Block (bilaterally, via 20ml % 0.25 bupivacain) and Intrathecal Morphine (100 mcg)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Marmara University
Postoperative Pain, Analgesics, Opioid
The Effects of TFPB on Opioid Consumption in Patients Undergoing HLDN
This study aims to evaluate whether a regional anesthesia technique called the transversalis fascia plane block (TFPB) can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive…
- Conditions
- Postoperative Pain, Analgesics, Opioid, Pain Management, Anesthesia Regional
- Trial name
- NCT07396753
- Testing
- Ultrasound-guided transversalis fascia plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Koç University
Drug Effect, Rib Fractures
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Rib fractures represent a common injury pattern this is highly associated with patient morbidity and mortality, as pain control remains a challenge.
- Conditions
- Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified
- Trial name
- NCT03305666
- Testing
- Liposomal bupivacaine injection, Bupivacaine indwelling catheter
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Denver Health and Hospital Authority
Cancer, Pain
Validation of a Screening Scale for Misuse of Opioid Analgesics
In oncology, pain is one of the main symptoms of discomfort. It has a significant impact on the quality of life.The use of opioid analgesics is recommended for the treatment of moderate to severe cancer pain.The misuse of opioid…
- Conditions
- Cancer, Pain, Opioid Analgesic Adverse Reaction
- Trial name
- VPOMIONCOL (NCT05761587)
- Testing
- Questionnaires
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Malignant Neoplasm of Breast
Analgesic Effects of Ultrasound Guided PEC Blocks on Analgesic Opioid Consumption of Cancer Surgery Patients
Examining the analgesic effect of ultrasound guided Pectoral Blocks on analgesic opioid consumption after surgical removal of breast tissue.
- Trial name
- NCT02495363
- Testing
- PECS Block, Bupivacaine 0.25-0.5%
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Pain, Chronic Disease
Medication Adherence Therapy for Opioid Abusing Pain Patients
The purpose of this study is to develop and pilot test a combined behavioral and pharmacological intervention designed to decrease pain, functional interference, and drug abuse while increasing medication adherence.
- Conditions
- Pain, Chronic Disease, Prescription Opioid Abuse
- Trial name
- NCT00249587
- Testing
- Methadone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Low Back Pain
A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain
The primary objective is to assess the efficacy of oxycodone/naloxone controlled-release tablets (OXN) for the management of opioid-induced constipation (OIC) compared with oxycodone controlled-release tablets (OXY) in subjects…
- Trial name
- NCT01427283
- Testing
- Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release
- Where
- 149 sites in United States
- Volunteers
- 450 people
- Sponsor
- Purdue Pharma LP
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Valdecoxib in Treating Chronic Pain in Cancer Patients
RATIONALE: Valdecoxib may be effective in relieving chronic pain in cancer patients. It is not yet known if valdecoxib is effective in treating chronic pain.
- Trial name
- NCT00021996
- Testing
- valdecoxib
- Where
- 2 sites in United States
- Sponsor
- Dana-Farber Cancer Institute
Opioid Use and Disposal
Impacting the Disposal of Unused Opioid
The purpose of this study is to compare the rates of proper opioid disposal in patients receiving an educational brochure compared to an automated text message delivered directly to patients' cell phones alongside the brochure…
- Trial name
- NCT04044105
- Testing
- Pamphlet education, Pamphlet education + texts
- Where
- United States
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Pain
A Study of JNS020QD in Patients With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of JNS020QD in patients with moderate to severe chronic pain who switched from opioid analgesics, as well as the safety and efficacy of long-term treatment (52…
- Trial name
- NCT01493245
- Testing
- JNS020QD
- Where
- 18 sites in Japan
- Volunteers
- 77 people
- Sponsor
- Janssen Pharmaceutical K.K.
Postoperative Analgesia, Pain, Postoperative
Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection
Breast cancer is the most common type of cancer in women. Mastectomy and axillary lymph node disection are commonly performed as part of the cancer management. This surgery can cause significant postoperative pain.
- Conditions
- Postoperative Analgesia, Pain, Postoperative, Opioid Consumption
- Trial name
- NCT03341234
- Testing
- Bupivacaine, Saline, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ataturk University
Pain
Safety, Pharmacokinetics (PK), and Effectiveness of Hydrocodone Bitartrate (HYD) Extended-Release Tablets in Children
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and effectiveness of Hydrocodone Bitartrate (HYD) tablets in children with moderate to severe pain requiring around-the-clock opioid analgesics.
- Trial name
- NCT02542098
- Testing
- HYD tablets
- Sponsor
- Purdue Pharma LP
Advanced Cancers
Self Reported Deviations From Opioid Analgesic Prescription
Primary Objective: 1. To determine the frequency of self-reported over and under use of opioid analgesics in patients with advanced cancer.
- Trial name
- NCT00907192
- Testing
- Personal Interview, Questionnaire
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- M.D. Anderson Cancer Center
Visceral Pain, Analgesia
Intraoperative Autonomic Blockade for Laparoscopic Cholecystectomy
This study proposes infiltrating the hepatoduodenal ligament and the serosal reflection of the gallbladder cystic plate with a combination of Bupivacaine (a long-acting local anesthetic) and Dexamethasone (a corticosteroid).
- Conditions
- Visceral Pain, Analgesia, Opioid Use, Postoperative Nausea
- Trial name
- ANB (NCT06753500)
- Testing
- Autonomic neural blockade
- Where
- 2 sites in Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad Simón Bolívar
Pain, Postoperative, Postoperative Nausea and Vomiting
Trigonelline Plus Sufentanil for Postoperative Analgesia After Laparoscopic Hysterectomy: A Randomized Controlled Clinical Trial
The goal of this clinical trial is to learn whether the combination of trigonelline and sufentanil can better control postoperative pain in adult women undergoing gynecologic laparoscopic surgery, while reducing discomforts such…
- Trial name
- TPS-GLS (NCT07914946)
- Testing
- Sufentanil, Trigonelline
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Hainan Medical College