Clinical trials: Opioid Pain Medication
Femoral Neck Fractures, Intertrochanteric Fractures
Opioid-Free Pain Treatment in Trauma Patients
Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.
- Conditions
- Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture
- Trial name
- NCT06078371
- Testing
- Opioid-free pain treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Virtual Reality, Musculoskeletal Pain
Virtual Reality Analgesia In Trauma Rehab
This will be a pilot study utilizing Virtual Reality Analgesia (VRA) as a first line nonpharmacologic analgesic intervention on the Acute Rehabilitation Unit.
- Conditions
- Virtual Reality, Musculoskeletal Pain, Opioid Use, Anxiety
- Trial name
- NCT03894592
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04858711
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Pain, Cancer
A Dose-Finding Study of Fentanyl (JNS020 QD) 1-Day Transdermal Patch in Participants With Cancer Pain
The purpose of this study is to evaluate the efficacy and safety of fentanyl 1-day application (JNS020QD) transdermal patch (patch containing a drug that is put on the skin so the drug can enter the body through the skin) and to…
- Trial name
- NCT00644787
- Testing
- Fentanyl 1-day transdermal patch (Titration Phase), Fentanyl 1-day transdermal patch (Double Blind Phase), Fentanyl 3-day transdermal patch (Double Blind Phase)
- Where
- 43 sites in Japan
- Volunteers
- 156 people
- Sponsor
- Janssen Pharmaceutical K.K.
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Postoperative Pain
Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia
Fast awakening from anesthesia is one of the major characteristics of remifentanil-associated anesthetic induction and maintenance, whereas corresponding pain during awakening influences patient's rehabilitation strongly.
- Trial name
- CARAN (NCT00738192)
- Testing
- Fentanyl citrate, Sufentanil citrate, Butorphanol tartrate
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanjing Medical University
Hysterectomy, Postoperative
A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy
The main objective of this study is to demonstrate the efficacy and safety of multiple-dose application of three different oral doses of CG5503 IR (tapentadol immediate release) compared to placebo in women undergoing abdominal…
- Trial name
- NCT00478023
- Testing
- Morphine, CG5503 IR
- Where
- 52 sites in Hungary, Latvia and 7 more
- Volunteers
- 854 people
- Sponsor
- Grünenthal GmbH
Knee Injuries, Knee Injuries and Disorders
Opioid Reduction Program for Total Knee Replacement Patients
In the context of prescribed opioids, research suggests that increased exposure is associated with long-term opioid use. Orthopedic surgeries are associated with the prescribing of more opioid narcotics than any other surgical…
- Conditions
- Knee Injuries, Knee Injuries and Disorders, Opioid Use
- Trial name
- TKR ORP (NCT05414942)
- Testing
- Opioid Reduction Program
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Tennessee
Analgesia Disorder
Study of PHN131 in Healthy Volunteers
To evaluate the safety and to investigate the pharmacokinetic properties and bioavailability of PHN131 in healthy volunteers
- Trial name
- NCT02192151
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PhytoHealth Corporation
Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection
Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy
The goal of this randomized controlled clinical trial is to determine whether adding a serratus anterior plane block (SAPB) to a pectoralis II (PECS II) block improves pain relief and reduces the need for opioids in adult women…
- Conditions
- Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection, Nerve Block; Pain Medication, Pectoralis Nerve Block
- Trial name
- PECS (NCT07881237)
- Testing
- Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS)
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- Lebanese American University
Ventral Hernia
CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs
Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care.
- Trial name
- NCT06565546
- Testing
- Opioid pain medication prescribed based on CYP2D6 genotype testing PLUS Acetaminophen and Gabapentin, Acetaminophen and Gabapentin: standard postoperative pain medications
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Pain Control
RCT: Suzetrigine vs Norco for Post-op Pain
Journavx (suzetrigine) is a novel non-opioid analgesic that is FDA approved for acute pain management and may offer a promising alternative for managing postoperative pain.
- Trial name
- NCT07195669
- Testing
- Suzetrigine (SUZ), Norco
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Jacob Lensing
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Opioid Use, Prescription Drug Abuse and Dependency
No Opioids PrescrIptions On Discharge After Surgery
Opioid analgesics are routinely prescribed for these patients for post-operative pain control. Even a short exposure to opioids in opioid-naïve patients following minor or major surgery has been associated with de novo habitual…
- Conditions
- Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
- Trial name
- NOPIOiDS (NCT04469868)
- Testing
- No opioids at discharge
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Albany Medical College
Opioid Use Disorder
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD.
- Trial name
- NCT06718491
- Testing
- Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University
Thoracic Surgery, Analgesics, Opioid
Opioid Free Anesthesia in Thoracic Surgery
Proper assessment of pain and adequate analgesia in thoracic surgery is a challenging issue for medical practitioners. Basic aspects of thoracic anaesthesia are general anesthesia, intubation with double lumen tube and separation…
- Conditions
- Thoracic Surgery, Analgesics, Opioid, Anesthesia, Conduction
- Trial name
- NCT04355468
- Testing
- Opioid Anesthesia, Opioid Free Anaesthesia
- Where
- Poland
- Volunteers
- 66 people
- Sponsor
- Medical University of Silesia
Analgesics, Opioid, Pain
Safety and Tolerability of Long-term Administration of OROS Hydromorphone HCI (Slow Release) in Cancer Pain
The primary purpose of this study was to characterize the pain control achieved with long-term repeated dosing of OROS hydromorphone (slow release) in patients with chronic cancer pain and the secondary purpose was to…
- Trial name
- NCT00410787
- Testing
- OROS hydromorphone HCI (slow release)
- Volunteers
- 68 people
- Sponsor
- Alza Corporation, DE, USA
Severe Pain
A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain.
This non-interventional, observational study evaluates the efficacy of Targinact with regard to pain relief in daily clinical practice in Belgium compared to the previous analgesic treatment.
- Trial name
- NCT01983137
- Testing
- Targinact® (oxycodone/naloxone)
- Where
- Belgium
- Volunteers
- 1,338 people
- Sponsor
- Mundipharma CVA
Postoperative Pain, Opioid Related Disorders
A Comparison of PR Oxycodone/Naloxone and PR Oxycodone After Cardiac Surgery
The aim of the study is to describe the effects of oxycodone/naloxone combination in comparison to oxycodone for the treatment of postoperative pain in patients undergoing cardiac surgery.
- Trial name
- NCT01374763
- Testing
- Oxycodone, Prolonged-release oxycodone/naloxone
- Where
- Finland
- Volunteers
- 165 people
- Sponsor
- Kati Järvelä