Clinical trials: Opioid Pain Medication
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Computer + Fluency, Computer Only
Evaluation of a Computerized Opioid Overdose Prevention Program
Unintentional fatal drug overdose (OD) is now the 2nd leading cause of accidental death in the general population. Fatal OD from opioid analgesics specifically has increased over 400% between 1999 and 2008, and nonfatal overdose…
- Conditions
- Computer + Fluency, Computer Only, Treatment as Usual
- Trial name
- NCT02040077
- Testing
- Computer + Fluency, Computer Only, Treatment as Usual
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Fractures, Closed, Pain, Postoperative
Pain and Narcotic Usage After Orthopaedic Surgery
This study aims to 1) observe the course of pain, 2) utilization of opioid pain medication, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients undergoing…
- Conditions
- Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute
- Trial name
- NCT03991546
- Testing
- Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Christopher Anthony
Opioid Use Disorder
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD.
- Trial name
- NCT06718491
- Testing
- Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University
Healthy
Bioequivalence Trial of a New Opioid Combination Compared to Reference
The purpose of this study is to demonstrate bioequivalence of a new formulation to a reference
- Trial name
- NCT00460785
- Testing
- Opioid
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Adenotonsillectomy, Post-operative Analgesia
Non-opioids for Analgesia After Adenotonsillectomy in Children
The goal of this study is to determine if non-opioid pain control is a safe way to manage pain after adenotonsillectomy surgery in children.
- Conditions
- Adenotonsillectomy, Post-operative Analgesia, Opioid Use
- Trial name
- NCT03618823
- Testing
- Oxycodone, Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- David Chi, MD
Adenotonsillectomy, Post-operative Analgesia
Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy
The goal of this study is to determine if non-opioid pain control is a safe way to manage pain after intracapsular adenotonsillectomy surgery in children.
- Conditions
- Adenotonsillectomy, Post-operative Analgesia, Opioid Use
- Trial name
- NCT04791761
- Testing
- Oxycodone, Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- David Chi, MD
Neoplasm Metastasis, Palliative Care
A Study Of Tanezumab as Add-On Therapy to Opioid Medication In Patients With Pain Due To Cancer That Has Spread To Bone
The purpose of this study is to investigate the safety and efficacy of tanezumab in combination with opioids in treating pain due to cancer that has spread to bone.
- Trial name
- NCT00545129
- Testing
- Tanezumab 10 mg IV
- Where
- 39 sites in United States, Austria and 11 more
- Volunteers
- 59 people
- Sponsor
- Pfizer
Pain Control
RCT: Suzetrigine vs Norco for Post-op Pain
Journavx (suzetrigine) is a novel non-opioid analgesic that is FDA approved for acute pain management and may offer a promising alternative for managing postoperative pain.
- Trial name
- NCT07195669
- Testing
- Suzetrigine (SUZ), Norco
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Jacob Lensing
Neoplasms, Constipation
Methylnaltrexone for Opioid-induced Constipation in Cancer Patients
The purpose of this study is to evaluate the efficacy of methylnaltrexone in relieving opioid-induced constipation in cancer patients at various stages of disease.
- Conditions
- Neoplasms, Constipation, Opioid-Related Disorders
- Trial name
- NCT01004393
- Testing
- Methylnaltrexone bromide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Vermont