Clinical trials: Opioid Pain Medication
Pain Management, Immune Checkpoint Inhibitor
Study on the Relationship Between Opioid Drugs and the Therapeutic Efficacy of Immunotherapy
Relationship between pain and the efficacy of immunotherapy: Does the degree of pain control affect the therapeutic efficacy of ICIs? Does the use of opioid drugs independently affect the efficacy of immunotherapy?
- Conditions
- Pain Management, Immune Checkpoint Inhibitor, Opioid
- Trial name
- NCT07188857
- Volunteers
- 100 people
- Sponsor
- Hubei Cancer Hospital
Cancer Pain
Study to Evaluate Effectiveness and Tolerability of OROS Hydromorphone for Cancer Pain Treatment in Korean Patients
The purpose of this study is to evaluate the effectiveness and tolerability of Once-Daily OROS ("Osmotic Release Oral System" [a controlled release oral medication delivery system in the form of a tablet]) hydromorphone for…
- Trial name
- NCT01621100
- Testing
- OROS hydromorphone
- Where
- 6 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Janssen Korea, Ltd., Korea
Pain, Postoperative, Pain Uterus
Effects of Tapentadol Versus Oxycodone After Hysterectomy.
Opioids remain the first-line drugs for the treatment of moderate to severe postoperative pain, but the use is limited by well-known side-effects, most of which are dose-dependent.
- Conditions
- Pain, Postoperative, Pain Uterus, Pain, Acute, Opioid Use
- Trial name
- NCT03314792
- Testing
- Tapentadol, Oxycodone
- Where
- Norway
- Volunteers
- 86 people
- Sponsor
- Oslo University Hospital
Opioid-Refractory Chronic Cancer-Related Pain
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
This is a randomized, double-blinded, placebo-controlled, cross-over trial examining the effect of a series of two weekly intravenous infusions of lidocaine 4 mg/kg and ketamine 0.2 mg/kg in patients with moderate to severe…
- Trial name
- NCT07408193
- Testing
- Lidocaine and Ketamine Infusion
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- National and Kapodistrian University of Athens
Chronic Pain, Back Pain
CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial
The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective…
- Conditions
- Chronic Pain, Back Pain, Neck Pain, Opioid Misuse
- Trial name
- CARES (NCT06027099)
- Testing
- Tizanidine, MI-Opioid Taper, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 375 people
- Sponsor
- Stanford University
Pain, Pain, Postoperative
Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients
The main objective study is to compare the use of the cryoSPHERE probe to the standard-of-care method for pain management of patients receiving robotic-assisted thoracoscopic surgery, including reductions in opioid pain…
- Trial name
- NCT05276258
- Testing
- cryoSPHERE Ablation, Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Methodist Hospital Research Institute
Postoperative Pain
Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy
Investigators have designed a randomized controlled trial. Utilizing an open-label, randomized, controlled study methodology, this trial aims to explore a opioid-free, safe, and effective analgesic approach for thoracic surgery.
- Trial name
- NCT06570538
- Testing
- Ropivacaine, Sufentanil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of a new and a marketed tablet formulation under fasted and fed conditions in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137017
- Testing
- Norco 5Mg-325Mg Tablet, GRT7014 - Abuse Deterrent Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Analgesics, Opioid, Anesthetics, Local
Opioid Use of Local Anaesthetic Agents in Open Heart Surgery and Its Effect on Recovery
The aim of this randomized controlled study was to investigate the effect of injecting local anesthetic agents into the sternotomy incision site and around the drains on the amount of opioids used in the postoperative period and…
- Trial name
- NCT06642077
- Testing
- LIDOFAST 40 mg/2 ml + 0.025 mg/2 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Acute Pain
IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients
The goal of this randomized clinical trial is to compare the analgesic efficacy and side effect profile of IV acetaminophen as an analgesic adjunctive medication to IV hydromorphone for the treatment of acute pain experienced by…
- Trial name
- NCT03553498
- Testing
- IV acetaminophen, hydromorphone
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Albert Einstein College of Medicine
Anesthesia
Remifentanil on Hemodynamic Response to Anesthesia Induction
Effects of different doses of remifentanil on hemodynamic response to anesthesia induction in elderly patients ABSTRACT OBJECTİVE: The investigators compared the effects of three different doses of remifentanil infusion, which…
- Trial name
- NCT02763098
- Testing
- Remi 0.1, Remi 0.2, Remi 0.3
- Volunteers
- 90 people
- Sponsor
- Dokuz Eylul University
Medication Adherence
Study to Test the Efficacy of Online Education to Increase Safe Use of Opioid Medication.
The purpose of this project is to test whether an online pain medication intervention is a feasible and effective way to increase opioid pain medication safety.
- Trial name
- NCT01770314
- Testing
- Experimental
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Inflexxion, Inc.
Analgesics, Opioid, Anesthesia, Endotracheal
Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery
Opioid-free anesthesia (OFA) is a multimodal technique that eliminates intraoperative opioids by combining dexmedetomidine, ketamine, lidocaine, NSAIDs, and regional analgesia.
- Conditions
- Analgesics, Opioid, Anesthesia, Endotracheal, Anesthesia, General
- Trial name
- NCT06380244
- Testing
- anesthesia without opioids
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Comparison of US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural
Comparison of US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
The investigators hypothesize that US Bilateral Erector Spinae Plane Block, US Bilateral Quadratus Lumborum Block and Lumbar Epidural for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy resulting in…
- Trial name
- NCT06397300
- Testing
- bilateral Ultrasound guided erector spinae plane (ESP) block, quadratus lumborum block, lumbar epidural
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04858711
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid Use, Marijuana
MEMO-Medical Marijuana and Opioids Study
The study will examine how medical cannabis use affects opioid analgesic use over time, with particular attention to THC/CBD content, HIV outcomes, and severe adverse events.
- Conditions
- Opioid Use, Marijuana, Chronic Pain, HIV/AIDS
- Trial name
- NCT03268551
- Where
- 2 sites in United States
- Volunteers
- 257 people
- Sponsor
- Albert Einstein College of Medicine
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Valdecoxib in Treating Chronic Pain in Cancer Patients
RATIONALE: Valdecoxib may be effective in relieving chronic pain in cancer patients. It is not yet known if valdecoxib is effective in treating chronic pain.
- Trial name
- NCT00021996
- Testing
- valdecoxib
- Where
- 2 sites in United States
- Sponsor
- Dana-Farber Cancer Institute
Opioid Free Anesthesia
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery
Patients undergoing nephrectomy have a high incidence of postoperative pain. In the perioperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both.
- Trial name
- NCT05312541
- Testing
- pre emptive local anaesthetic wound infiltration
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital