Clinical trials: Opioid Pain Medication
Opioid Use, Pain, Postoperative
Comparison of Pain Relief After Hip Fracture Surgery: Hip and Groin Nerve Block
This observational prospective double-blind study aims to compare the analgesic effectiveness of the pericapsular nerve group block (PENG) group and the suprainguinal fascia iliaca compartment block(SFICB) group to be applied to…
- Conditions
- Opioid Use, Pain, Postoperative, Hip Fractures
- Trial name
- NCT06443892
- Testing
- Pericapsular Nerve Block (PENG), Suprainguinal Fascia Iliaca Compartment Block (SFICB)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Ankle Sprains, Telerehabilitation
Telehealth Delivered Physical Rehabilitation for an Ankle Sprain
A vast majority (75-85%) of ankle sprain patients treated in emergency departments (ED) receive pain medication and are not referred for physical rehabilitation.
- Conditions
- Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic
- Trial name
- NCT04520854
- Testing
- Telehealth Protocol, Usual Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Kyle Kosik
Analgesia
Regional Blocks for Lumbar Disc Surgery Analgesia
Objective The goal of this prospective randomized controlled experiment was comparing the analgesic efficacy, opioid needs, and adverse effect profiles of Paravertebral Block (PVB), Thoracolumbar Interfascial Plane Block (TLIP)…
- Trial name
- NCT06933641
- Testing
- Regional Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Erzincan University
Lumbar Disc Herniation
Comparison of the Efficacy of Thoracolumbar Interfascial Plane Block and Erector Spina Plane Block in Lumbar Discectomy
Patients who will undergo herniated disc surgery have serious pain after surgery. In order to minimise this pain and to ensure that they recover more quickly and use less morphine-derived painkillers, we aim to apply two types of…
- Trial name
- NCT05999253
- Testing
- Modified thoracolumbar plane block (mTLIP), Erector spinae plane block (ESP)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Mastectomy; Lymphedema
Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After Mastectomy
Breast cancer is the most common type of cancer in women. Removal of the breast, called "mastectomy", is performed either when there is cancer-or an increased risk of cancer-in the breast.
- Trial name
- NCT05444361
- Testing
- Cryoneurolysis
- Where
- 5 sites in United States
- Volunteers
- 216 people
- Sponsor
- University of California, San Diego
Pain
A Safety and Efficacy Study of JNS024 Extended Release (ER) in Japanese and Korean Patients With Chronic Malignant Tumor-Related Cancer Pain
The purpose of this study is to evaluate the safety and efficacy of R331333 (referred to as JNS024 Extended-Release (ER) or CG5503) compared with an active comparator (oxycodone Controlled Release (CR)) in Japanese and Korean…
- Trial name
- NCT01165281
- Testing
- Oxycodone CR, R331333 (referred to as JNS024 ER or CG5503)
- Where
- 52 sites in Japan, South Korea
- Volunteers
- 343 people
- Sponsor
- Janssen Research & Development, LLC
Opioid Use Disorders, Tooth Extraction Status Nos
Opioid Analgesic Use and Disposal Following Outpatient Dental Surgery
Background: Overdose deaths from prescription opioid analgesics quadrupled from 4,000 cases to nearly 17,000 cases annually during 1999-2011.
- Trial name
- NCT02814305
- Testing
- Financial, Educational
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer
Double Bedtime Dosing During Immediate-release Morphine Administration to Cancer Patients
This is a double -blind randomized crossover study to provide evidence for the expert advice based recommendation of the Expert Working Group of the European Association for Palliative Care (EAPC) that patients during treatment…
- Trial name
- NCT00201539
- Testing
- single dose Morphine, double dose Morphine
- Where
- 2 sites in Norway
- Volunteers
- 19 people
- Sponsor
- Norwegian University of Science and Technology
Thyroid Cancer, Thyroid Nodule
Minimizing Narcotic Analgesics After Endocrine Surgery
This research is being done to better understand and test if the investigators can minimize narcotic medication for controlling pain after thyroid or parathyroid surgery.
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Neoplasms, Thyroid Goitre
- Trial name
- NCT03469310
- Testing
- Acetaminophen 500Mg Cap, Tylenol #3 Oral Tablet, Tramadol
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Minerva A Romero Arenas
Chronic Pain
Intrathecal Morphine Compared to Conventional Medical Management for Pain Control and Opioid-related Side Effects
This study compares two different ways to treat pain. The two ways are: 1. continuing to take current pain medication(s) or 2. receiving morphine, a pain medication from a drug pump (a system to deliver drug to your body) that is…
- Trial name
- CONVERT-TDD (NCT01924182)
- Testing
- SynchroMed Infusion System and Intrathecal Morphine Sulfate, Conventional Medicine
- Where
- 6 sites in United States
- Volunteers
- 7 people
- Sponsor
- MedtronicNeuro
Pain, Opioid Use
The Experiences of People Prescribed Opioid Pain Medicines
Opioids are morphine-type medicines which come from the opium poppy or are similar-to morphine. They are very effective for short-term pain, cancer pain, and pain at the end of life.
- Trial name
- NCT04888897
- Where
- United Kingdom
- Volunteers
- 619 people
- Sponsor
- University of Nottingham
Nephrolithiasis, Urolithiasis
Perioperative Pregabalin in Ureteroscopy: a Pilot
The investigators propose a pilot clinical trial on the use of perioperative pregabalin in order to decrease ureteral stent related symptoms and decrease opioid usage after ureteroscopy with stent placement.
- Conditions
- Nephrolithiasis, Urolithiasis, Perioperative/Postoperative Complications, Pain, Postoperative
- Trial name
- NCT03927781
- Testing
- Pregabalin 300mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Pain
Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring
This research is being done to compare two methods of giving fentanyl, a narcotic often given to patients following brain surgery and determine if one method has more side effects than the other.
- Trial name
- NCT01327677
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Johns Hopkins University
Spine Fusion, Pain, Postoperative
The Impact of Sublingual Sufentanil on Postoperative Pain and Analgesic Requirements in Spine Surgery Patients
In this study the investigators plan to examine the perioperative use of sufentanil sublingual (SL) in the analgesic regimen for spine surgery, one of the most common surgeries performed in the US.
- Conditions
- Spine Fusion, Pain, Postoperative, Opioid Use
- Trial name
- NCT04263909
- Testing
- Sublingual Tablet
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Pain, Postoperative, Analgesics, Opioid
Phase 1: Randomized Evaluation of a System to Deliver Mobile Cognitive Behavioral Therapy
The clinical study described in this Clinical Investigation Plan (CIP) will be completed in two stages, Phase I and Phase II. The results of Phase I will confirm patient use of InCaveo's EOA system with integrated mobile CBT but…
- Trial name
- P1RESPECT (NCT04836169)
- Testing
- InCaveo's EOA system with integrated mobile CBT
- Volunteers
- 30 people
- Sponsor
- InCaveo
Pain, Postoperative, Fracture, Ankle
Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture
The purpose is to find out if incorporation of an intraoperative electro auricular acupuncture protocol when added to a standard multimodal analgesic regimen for patients undergoing surgery to repair lower leg fracture under…
- Conditions
- Pain, Postoperative, Fracture, Ankle, Pilon Fracture of Tibia, Foot Fracture
- Trial name
- NCT05984433
- Testing
- Auricular acupuncture
- Where
- United States
- Sponsor
- Baylor College of Medicine
Moderate to Severe Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute moderate to severe…
- Trial name
- NCT01016808
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 5 sites in United States
- Volunteers
- 522 people
- Sponsor
- QRxPharma Inc.
Pain, Osteoarthritis, Hip
Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
This clinical trial tests the pain relieving effectiveness of OROS hydromorphone, a once-daily formulation of a strong opioid against placebo in patients, who are suffering from pain due to osteoarthritis of the hip or the knee…
- Conditions
- Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00980798
- Testing
- OROS hydromorphone HCl
- Where
- 12 sites in Czechia, Romania and 2 more
- Volunteers
- 288 people
- Sponsor
- Janssen-Cilag International NV
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics