Clinical trials: Opioid Prescribing
Acute Pain
Electronic Defaults to Reduce Opioid Prescribing in Emergency Department and Primary Care Settings
The goal of this research is to investigate the impact of changing opioid analgesic prescribing defaults on the quantity of opioids prescribed for acute non-cancer pain in adult primary care and emergency department settings.
- Trial name
- NCT03003832
- Testing
- Change in electronic health record default for new opioid analgesic prescriptions
- Volunteers
- 15,000 people
- Sponsor
- Montefiore Medical Center
Acute Pain, Headache
Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care
The investigators will assess whether behavioral science-based interventions can "nudge" providers towards more evidence-based care for patients with acute non-cancer pain.
- Conditions
- Acute Pain, Headache, Musculoskeletal Pain
- Trial name
- NCT03537573
- Testing
- Usual Care/Guideline, Opioid Justification, Provider Comparison
- Where
- United States
- Volunteers
- 22,616 people
- Sponsor
- University of Pittsburgh
Substance-Related Disorders
Behavioral Insights to Encourage Judicious Prescribing of Opioids
In collaboration with the San Diego Medical Examiner's Office and the State of California's controlled Substance Utilization Review and Evaluation System (CURES), the investigators propose to review opioid poisonings over the…
- Trial name
- NCT02790476
- Testing
- Letters
- Where
- United States
- Volunteers
- 851 people
- Sponsor
- University of Southern California
Opioid Misuse, Chronic Pain
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
The NIH Helping to End Addiction Long-term (HEAL) initiative has identified a critical next step to addressing the opioid crisis: improving treatments for opioid misuse behaviors (e.g., using more opioids than prescribed, illicit…
- Trial name
- NCT05182606
- Testing
- Pilot study of algorithms implementation package
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Related Disorders, Opiate Addiction
Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could…
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920775
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 360,000 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid Prescribing
Postoperative Nudges to Reduce Opioid Prescribing
This study tests the effectiveness of two email-based behavioral nudges, one based on peer behavior and one based on best practice guidelines, in reducing excessive opioid prescriptions after surgery.
- Trial name
- POST-OP (NCT05070338)
- Testing
- Guideline-Based (Injunctive Norm) Nudges, Peer-Based (Social Norm) Nudges
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- RAND
Back Pain, Neck Pain
A Naturalistic Experiment Evaluating the Impact of Medicaid Treatment Reimbursement Changes on Opioid Prescribing and Patient Outcomes Among Patients With Back Pain
Back on Track is a quasi-experimental, mixed-methods study of a unique natural experiment that will answer the question: what is the comparative effectiveness of different payer or health-system strategies that aim to prevent…
- Trial name
- Back on Track (NCT03393143)
- Where
- United States
- Volunteers
- 2,748 people
- Sponsor
- Kaiser Permanente
Opioid Use
Peer Comparison Feedback on Opioid Prescribing
We aim to determine if descriptive normative feedback of peer prescribing reduces opioid analgesic prescribing by emergency medicine providers
- Trial name
- NCT03183882
- Testing
- Personal Feedback, Peer Normative Comparison Feedback
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Pittsburgh
Opioid Abuse, Unspecified
Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 1: EHR Nudges
The opioid epidemic has had a tremendous negative impact on the health of persons in the U.S. The objective of the trial 1 of Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-T1), is to…
- Trial name
- AESOPS-T1 (NCT04477304)
- Testing
- Opioid Naive, OR, At-risk for long-term use, OR, Long-term opioid recipient
- Where
- United States
- Volunteers
- 555 people
- Sponsor
- University of Southern California
Pain, Acute, Opioid Use, Unspecified
EMR Defaults to Nudge Opioid Prescribing
The investigators conducted a prospective, block-randomized study to determine whether and to what extent changes in the default settings in the electronic medical record (EMR) affect opioid prescriptions for patients discharged…
- Trial name
- NCT04155229
- Testing
- Default settings for opioid prescriptions (acetaminophen/hydrocodone, oxycodone, acetaminophen/oxycodone)
- Volunteers
- 104 people
- Sponsor
- University of California, San Francisco
Opioid Abuse, Opioid Misuse
Opioid Reduction Toolkit Reduces Opioids Prescribed and Consumed
Investigators studied a baseline population of patients receiving pancreatectomies at their institution and determined how many opioid pills each patient was prescribed and how many they took.
- Conditions
- Opioid Abuse, Opioid Misuse, Pain
- Trial name
- NCT05363436
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Thomas Jefferson University
Chronic Pain
Evaluating Chronic Pain Self-Management Support with an Opioid De-prescribing Intervention
This study will evaluate the outcomes of the combination of chronic pain self-management support with opioid deprescription, improve our understanding of the experiences and perspectives of patients and healthcare providers with…
- Trial name
- NCT03890263
- Testing
- Chronic Pain Self-Management Support
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Queen's University
Opioid Prescribing
Reducing Post-Operative Opioid Prescribing in Southeastern North Carolina
The goal of this stepped-wedge cluster randomized trial is to evaluate whether an opioid stewardship intervention improves post-operative opioid prescribing practices.
- Trial name
- NCT07566182
- Testing
- Usual Care, Opioid Stewardship Intervention
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Clinical Audit, Quality Improvement
Impact Evaluation of the Therapeutic Initiative's Prescribing Portrait and Therapeutics Letter on Opioid Use by Dentists
The aim of this study is to estimate the impact of providing personalized prescribing data and educational materials on opioid prescribing to dentists in British Columbia, Canada. The main research questions are: 1.
- Conditions
- Clinical Audit, Quality Improvement, Opioid, Dentistry
- Trial name
- NCT07317869
- Testing
- Regular intervention, Enhanced intervention
- Where
- Canada
- Volunteers
- 3,498 people
- Sponsor
- University of British Columbia
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Pain, Chronic, Communication Research
Improving Communication About Pain and Opioids
The overall goal of this protocol is to pilot test a clinician training intervention that uses standardized patients (trained actors playing patient roles) as instructors who impart communication skills to primary care…
- Conditions
- Pain, Chronic, Communication Research, Opioid Use
- Trial name
- NCT03629197
- Testing
- Clinicians - Communication skills training, Clinician Control, Patient seeing trained clinician
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- University of California, Davis
Opioid Tapering
Opioid Tapering After Hospital Discharge: Testing an Intervention to Improve Post-operative Opioid Prescribing
The investigator team proposes a randomized clinical trial (RCT) to test a discharge opioid taper support ("DOTS") intervention that is embedded in the providers' workflow in the EHR to prompt them to prescribe an opioid taper…
- Trial name
- DOTS (NCT07510373)
- Testing
- Treatment as Usual (TAU), Telephonic Support (TS) Providers, DOTS Intervention
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Montefiore Medical Center
Drug Addiction
Comparing Acute and Continuous Drug Abuse Treatment: A Randomized Clinical Trial
The purpose of this 2 year study is to conduct a fully powered effectiveness trial comparing recovery trajectories of 200 drug dependent adults (the subjects) who will be randomly assigned to Treatment as Usual (TAU) or TAU +…
- Trial name
- NCT01003496
- Testing
- Treatment as Usual (TAU), TAU + Long-Term Recovery Management
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Wright State University
Opioid Use
Promoting Clinical Guidelines for Opioid Prescribing
This study aims to understand the optimal sequencing and combination of implementation strategies that specific types of clinics and prescribers need to adopt clinical guidelines for opioid prescribing.
- Trial name
- NCT04044521
- Testing
- Systems consultation
- Where
- 2 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison