Clinical trials: Opioid Prescribing
Opioid Use
24-hour Oral Morphine Equivalent Based Opioid Prescribing After Surgery
The investigators will utilize the electronic health record to individualize pain therapy in surgical patients after hospital discharge using last 24-hour opioid intake as the decision variable for the amount of opioid pain pills…
- Trial name
- NCT04043143
- Testing
- Arm 1 Prescription As Usual, Arm 2 Prescription Tool Intervention
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Analgesics, Opioid, Acute Pain
Alternatives to Dental Opioid Prescribing After Tooth Extraction
The goal of this clinical trial is to test a three-item intervention in oral surgeons who remove teeth. The main questions it aims to answer are: Can the intervention reduce opioid prescriptions to adolescents and young adults…
- Conditions
- Analgesics, Opioid, Acute Pain, Tooth Extraction, Adolescent
- Trial name
- ADOPT (NCT06275191)
- Testing
- Multicomponent intervention, Usual care
- Where
- United States
- Volunteers
- 38,159 people
- Sponsor
- Douglas Oyler
Opioid Use
Best Practice Alert for Opioid Prescribing
The investigators will embed a developed decision support tool into the electronic health record (EHR) to individualize pain therapy in surgical patients after hospital discharge and test its performance in a pragmatic clinical…
- Trial name
- NCT04446975
- Testing
- BPA
- Where
- United States
- Volunteers
- 21,689 people
- Sponsor
- University of Colorado, Denver
Postoperative Pain, Opioid Use
Liberal vs. Restricted Post-discharge Opioid Prescribing Following Midurethral Sling
The specific objective of this proposal is to evaluate pain and opioid use following a midurethral sling (MUS) under two different opioid prescribing schemes.
- Trial name
- NCT04277975
- Testing
- Liberal post-discharge opioid prescribing, Restricted post-discharge opioid prescribing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Neurologic Impairment by Opioids
Non-intrusive Detection of Temporary Neurologic Impairment by Opioids
The investigators aim to prove the feasibility of a non-invasive means to identify temporary neurological impairment resulting from the use of a commonly prescribed opioid by identifying an oculomotor biosignature associated with…
- Trial name
- NCT05489601
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Zxerex Corporation
Pain
Analgesic Use and Effectiveness for Dental Procedures
Opioid analgesics prescribed by dentists may contribute to the larger national issue of the use and abuse of the drug. On occasion dental pain may be sufficiently severe to support the use of opioids.
- Trial name
- NCT02929602
- Where
- United States
- Volunteers
- 2,773 people, healthy volunteers welcome
- Sponsor
- Pearl Network
Back Pain, Osteoarthritis
Strategies for Prescribing Analgesics Comparative Effectiveness Trial
Chronic musculoskeletal pain conditions are among the most prevalent conditions in VA primary care. Over the past two decades, improved clinical attention to pain has been associated with exponentially greater use of long-term…
- Trial name
- SPACE (NCT01583985)
- Testing
- Opioid-intensive prescribing strategy, Opioid-avoidant prescribing strategy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- VA Office of Research and Development
Opioid Prescribing, Surgical Procedure, Unspecified
A Clinician-Focused Nudging Intervention to Optimize Post-Surgical Prescribing
This is a pilot single site randomized controlled trial to assess the feasibility and acceptability of a nudging intervention providing surgeons with procedure-specific feedback regarding patients' postoperative opioid…
- Trial name
- NCT05299528
- Testing
- Direct Feedback
- Where
- United States
- Volunteers
- 465 people
- Sponsor
- Vanderbilt University Medical Center
Opioid Use, Opioid-Related Disorders
Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients
Risk of long-term opioid dependence increases with initial opioid dose/duration, but despite recent Centers for Disease Control and Prevention (CDC)-endorsed minimum doses for initial opioid prescription, primary care providers…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency
- Trial name
- NCT03377855
- Testing
- Default Prescribing Change
- Where
- 2 sites in United States
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Medication Abuse, Harm Reduction
Evaluation of Clinical Decision Support in Opioid Tapering
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing
- Trial name
- NCT06527079
- Testing
- Observational study without a prospective intervention
- Volunteers
- 200,000 people
- Sponsor
- University of Colorado, Denver
Opiate Addiction
NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction
The objective of this study is to determine whether the closely supervised provision of injectable, pharmaceutical-grade heroin (in combination with oral methadone) is more effective than methadone therapy alone in recruiting…
- Trial name
- NCT00175357
- Testing
- Methadone, Diamorphine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 192 people
- Sponsor
- University of British Columbia
Opioid Abuse and Addiction
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution
The objective of this observational feasibility project is to assess the feasibility and acceptability of universal screening and measurement based care for opioid use disorder (OUD) utilizing a computer software program in a…
- Trial name
- MBC4OUD (NCT04059016)
- Testing
- MBC4OUD
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Opioid Prescribing, Prescription Drug Misuse
E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs
This study will test e-mails to encourage engagement with the Minnesota prescription monitoring program (PMP/PDMP) and will evaluate the effect of these e-mails on PMP/PDMP use and controlled substance prescribing.
- Trial name
- NCT06443385
- Testing
- PDMP Legal Mandate E-mail, PDMP Clinical Benefit E-mail
- Where
- United States
- Volunteers
- 7,872 people, healthy volunteers welcome
- Sponsor
- Columbia University
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Opioid-Naive Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601493)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 631 people
- Sponsor
- University of Minnesota
Back Pain
Pain Assessment and Quality of Life in Back Pain Patients: Role of Milnacipran
1. To show that patients with greater pain sensitivity will show greater improvement in their symptoms (self-reported pain intensity, mood, sleep, and quality of life) than those with lower pain sensitivity, based on QST, after…
- Trial name
- NCT01221740
- Testing
- Savella
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Opioid Use, Opioid Prescribing
Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations
This study will characterize patient pain and opioid use after an initial opioid prescription for acute pain.
- Trial name
- NCT04509115
- Testing
- Short-acting opioid prescription for acute pain
- Where
- 5 sites in United States
- Volunteers
- 1,709 people
- Sponsor
- Yale University