Clinical trials: Opioid Use, completed
Post-operative Pain, Acute, Opioid Use, Unspecified
Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care
The goal of this clinical trial is to learn if the Pain Coach App will result in less opioids being prescribed to and used by patients undergoing Shoulder/Hip/Knee Arthroplasty surgery while maintaining the same or better pain…
- Conditions
- Post-operative Pain, Acute, Opioid Use, Unspecified, Arthroplasty Complications, Knee Osteoarthritis
- Trial name
- NCT06469177
- Testing
- Pain Coach App
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
HIV Infections, Opioid Use
Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called [18F]NOS.
- Trial name
- NCT04401917
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pain, Postoperative, Pain, Acute
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
The purpose of this study is to determine whether administration of a pectoral nerve blocks (Pecs I and II) with 0.25% bupivacaine are more effective as compared to placebo to provide analgesia for cardiac implantable electronic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chest, Pain
- Trial name
- NCT05283980
- Testing
- 0.25% Bupivacaine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Opioid Craving, Opioid Use Disorder
Developing a Clinical Outcome Assessment for Opioid Craving
The purpose of this study is to collect information about opioid craving so that the investigators can develop an opioid craving assessment to improve treatments for individuals with opioid use disorder.
- Conditions
- Opioid Craving, Opioid Use Disorder, Measure Development
- Trial name
- NCT05109429
- Testing
- Neutral Cue-induced Craving, Visual Opioid Cue-induced Craving, Visual and Tactile Opioid Cue-induced Craving
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Covid-19, Substance Use
Leveraging Social Networks to Increase COVID-19 Testing Uptake
This two-year project will adapt and conduct a trial examining the ability of two recruitment strategies, chain-referral and credible messenger, to reach those who use opioids and other substances in order to increase their…
- Conditions
- Covid-19, Substance Use, Opioid Use
- Trial name
- NCT04873401
- Testing
- Chain-referral, Credible Messenger
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Use Disorder
Piloting a Web Resource for Pregnancy OUD in Jail
The goal of this clinical trial is to pilot an adaptable, user-friendly, web-accessible toolkit and implementation strategy for jails to be able to provide access to pregnancy-specific opioid use disorder (OUD) care.
- Trial name
- NCT05853289
- Testing
- Maternal Opioid use Disorder Management and Care Resources (MOM CARE) in Custody
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Use Disorder
KIOS Mobile App Evaluation
Evaluation of a mobile medical app (KIOS) vs. treatment as usual for the treatment of opioid use disorder (OUD).
- Trial name
- NCT06212557
- Testing
- KIOS App, KIOS App education, Treatment as usual
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tobacco Use, Opioid Use Disorder
E-cigarette Switching Older Adults
The goal of this clinical trial is to learn if adults 50 years and older who currently smoke tobacco and are in treatment for opioid use disorder will switch to using e-cigarettes instead of continued smoking.
- Conditions
- Tobacco Use, Opioid Use Disorder, Tobacco-Related Disorders
- Trial name
- NCT06534905
- Testing
- E-cigarette, Control/Standard Advice
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Opioid-use Disorder, Pregnancy Related
STEPuP: Prenatal Provider Education and Training to Improve Medication-assisted Treatment Use During Pregnancy
This research will test the effectiveness of a prenatal provider education and training program designed to facilitate provider adoption of evidence-based practices for the treatment of OUD during pregnancy.
- Trial name
- STEPuP (NCT04527926)
- Testing
- STEPuP Intervention, Usual Care
- Where
- United States
- Volunteers
- 1,022 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Use Disorder, Substance-Related Disorders
Maternal Brain Imaging in Opioid Use Disorder
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved.
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related
- Trial name
- NCT06008990
- Testing
- Buprenorphine, Maternal Brain MRI, Blood Samples
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid-use Disorder
Kentucky Women's Justice Community Opioid Innovation Network
This trial will test the effectiveness of delivering medication for opioid use disorder (MOUD) pre-treatment via telehealth, alone and with peer navigation, to increase MOUD initiation and maintenance in the community following…
- Trial name
- W-JCOIN (NCT04069624)
- Testing
- MOUD Pre-Treatment Telehealth, MOUD Pre-Treatment Telehealth and Peer Navigator, Services as Usual
- Where
- 9 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Michele Staton
PTSD, Depression
Participatory System Dynamics vs Usual Quality Improvement: Staff Use of Simulation as an Effective, Scalable and Affordable Way to Improve Timely Mental Health Care?
Evidence-based VA care is best for meeting Veterans' mental health needs, such as depression, PTSD and opioid use disorder, to prevent suicide or overdose. But some key evidence-based practices only reach 3-28% of patients.
- Conditions
- PTSD, Depression, Opioid Use Disorder
- Trial name
- NCT04208217
- Testing
- Modeling to Learn (MTL), Usual quality improvement (QI)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Use Disorder, Opioid Use Disorder
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine…
- Conditions
- Cocaine Use Disorder, Opioid Use Disorder, Stimulant Use Disorder
- Trial name
- BED IN 43 (NCT05610072)
- Testing
- n-acetylcysteine, Hydromorphone
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Opioid Use Disorder
A Multi-site Intervention to Expand Hospital Based OUD Treatment Provision
The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD.
- Trial name
- NCT06291090
- Testing
- OUD treatment intervention
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid Use Disorder
Study of the BIOPIN 6 Naltrexone Implant in Healthy Adults
The purpose of this study is to evaluate the safety and blood levels of a medicine, naltrexone, contained within an implant in healthy volunteers age 18 to 65 years.
- Trial name
- NCT06216132
- Testing
- BIOPIN-6 Active Implant with Naltrexone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Akyso Therapeutics, LLC
Marijuana Use, Opioid Use
Reinforcing Effects of Marijuana and Opioids
The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for…
- Trial name
- NCT05485012
- Testing
- Marijuana, Opioid
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Pain, Postoperative, Pain, Acute
External Oblique Intercostal Block in Laparoscopic Cholecystectomy
Adequate postoperative pain management is essential for improving patient comfort and recovery after laparoscopic cholecystectomy.
- Conditions
- Pain, Postoperative, Pain, Acute, Opioid Use
- Trial name
- NCT07164664
- Testing
- External Oblique Intercostal Block, Port-Site Infiltration, ıv morphine PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University