Clinical trials: Opioid Use Disorder (OUD), active
Opioid Use Disorder (OUD), Chronic Pain
Opioid Adherence and Support Through Innovative Texting Strategies
The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages on medication adherence and managing craving, pain, and withdrawal symptoms in people taking medications for opioid use disorder…
- Trial name
- OASIS (NCT07350148)
- Testing
- Mindfulness text messages
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of New Mexico
Opioid Use Disorder
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD.
- Trial name
- NCT06718491
- Testing
- Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Opioid Use Disorder
The Emergency Department Longitudinal Integrated Care
Collaborative care is a comprehensive patient-centered model of healthcare delivery targeting behavioral health or substance use that stems from the chronic disease management framework.
- Trial name
- ED-LINC2 (NCT05327166)
- Testing
- ED-LINC
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Washington
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Interpersonal Brain Function in Opioid Use
The purpose of this study is to assess dyadic physiological coherence and subjective empathic attunement during meditation practices and their association with opioid-related outcomes.
- Trial name
- NCT07386769
- Testing
- Meditation, Psychoeducation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Alcohol Use Disorder, Opioid Use Disorder
TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)
The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal…
- Trial name
- TMS4OUDAUD (NCT07171359)
- Testing
- TMS Low-Dose, TMS High-Dose
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington State University
Opioid Use Disorder
PEX010-Assisted Therapy for Opioid Use Disorder (OUD): a Feasibility Study
The goal of this clinical trial is to learn if it is feasible to use PEX010 for the treatment of opioid use disorder in adults. The study will also assess the safety of PEX010.
- Trial name
- NCT06608459
- Testing
- PEX010-Assisted Therapy
- Volunteers
- 10 people
- Sponsor
- Filament Health Corp.
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Opioid Use Disorder
Integrating Brain, Neurocognitive, and Computational Tools in OUD
The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on…
- Trial name
- NCT06136247
- Testing
- Neurocognitive battery, fNIRS
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Pennsylvania
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two…
- Trial name
- P2PH (NCT07073924)
- Testing
- Implementation strategy bundle
- Where
- 4 sites in United States
- Volunteers
- 536 people
- Sponsor
- University of Pittsburgh
Opioid Use Disorder
Expanding Medication-Assisted Therapies in Central Asia
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the…
- Trial name
- ExMAT CA (NCT05579470)
- Testing
- NIATx
- Where
- 4 sites in United States, Kazakhstan and 2 more
- Volunteers
- 900 people
- Sponsor
- Yale University
Loneliness, Opioid Use Disorder
Improving Social Connectedness Through Digital Health to Enhance Recovery From OUD Among the Justice Involved Population
People with a history of Opioid Use Disorder and criminal justice involvement are more likely to experience loneliness following release from jail/prison leading to negative outcomes such as treatment dropout and increased…
- Trial name
- STAR (NCT06896656)
- Testing
- Marigold Mobile Peer Support Intervention, Resources
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rhode Island Hospital
Opioid Use Disorder (OUD), Addictology
Autonomous Methadone Delivery System by Nurses
Initiations of methadone treatment for opiode use disorder (OUD) are carried out in France in specialized centers, known as centers for care, support and prevention in addictology (CSAPA) In this way, hospital practitioners…
- Trial name
- DIADEME (NCT07085377)
- Testing
- DIADEME strategy, Controle strategy, Individual semi directive interview
- Where
- 8 sites in France
- Volunteers
- 182 people
- Sponsor
- Hospices Civils de Lyon
Withdrawal Symptoms, Opioid Use Disorder
Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will…
- Conditions
- Withdrawal Symptoms, Opioid Use Disorder, Opioid Use
- Trial name
- VNS in OUD UH3 (NCT05834478)
- Testing
- Transcutaneous Cervical Vagal Nerve Stimulation, [F-18]Fallypride
- Where
- 6 sites in United States
- Volunteers
- 103 people
- Sponsor
- Emory University
Schizophrenia, Cannabis Dependence
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis.
- Conditions
- Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism
- Trial name
- NCT01730781
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use Disorder
Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use
The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal.
- Trial name
- ROLDI (NCT06379984)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Opioid Use Disorder, Chronic Back Pain
Focused Ultrasound for the Complex Patient
The goal of this clinical trial is to to inhibit the anterior insula (AI) with low intensity focused ultrasound (LIFU) to determine the causal role for the AI in pain processing, anxiety, and opiate cue-induced craving.
- Conditions
- Opioid Use Disorder, Chronic Back Pain, Anxiety
- Trial name
- LIFU (NCT06453109)
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Opioid Dependence, Opioid Use Disorder (OUD)
VK4-116 Phase I Study With Food-Effect
This first-in-human, randomized, double-blind, placebo-controlled, single ascending dose (SAD), phase I study is designed to assess the safety, tolerability and pharmacokinetics of VK4-116 in healthy volunteers in fasted and fed…
- Trial name
- NCT06808932
- Testing
- VK4-116
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder
Pilot Research on Opioid Use Disorder
This study evaluates the effects of peripheral nerve stimulation on opioid withdrawal, craving, and use in participants with opioid use disorder (OUD) who are initiating treatment with buprenorphine/naloxone.
- Trial name
- PROUD (NCT04244227)
- Testing
- Empower Neuromodulation System
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Theranova, L.L.C.
Opioid Use Disorder
Psilocybin on Brain Mechanisms of Motivation in OUD
The goal of this study is to test addiction-related brain circuitry (motivation/reward and inhibition) as well as neurocognitive circuitry prior to and following low or high dose psilocybin (PEX010 from Filament).
- Trial name
- NCT06810310
- Testing
- Psilocybin (high dose), psilocybin (low dose)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania