Clinical trials: Opioid-Free Anesthesia
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Analgesic Drug Dependence, Colectomy
Opioid Free Anesthesia vs. Opioid Anesthesia Techniques.
A comparison of post-operative opioid use in Laparoscopic Colectomy patients receiving Opioid or Opioid-free Anesthesia.
- Trial name
- OFA vs OA (NCT03367988)
- Testing
- Opioid Anesthesia, Opioid-free Anesthesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Florida
Functional Endoscopic Sinus Surgery
Opioid Free Anesthesia in ENT Surgery
Opioid Free Anesthesia (OFA) - which has been applied mainly in bariatric surgery - has begun to receive more and more attention and to obtain fanatical supporters versus conventional anesthesia.
- Trial name
- NCT04105946
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Temporomandibular Joint Disorders
The Effect of Opioid-Free Anesthesia in TMJ Surgery
This study aims is to evaluate the effect of opioid free total intravenous anesthesia on postoperative quality of recovery in patients undergoing oral and maxillofacial surgery (OMF) temporomandibular joint (TMJ) surgery.
- Trial name
- NCT04724759
- Testing
- Dexmedetomidine / Ketamine / Lidocaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Colorectal Surgery
Opioid-free Vs Traditional Balanced Anesthesia in Laparoscopic Colorectal Surgery
The goal of this clinical trial is to compare opioid free anesthesia versus opioid anesthesia in patients undergo laparoscopic colorectal surgery.
- Trial name
- OFA_GAL_21 (NCT05887258)
- Testing
- Opioid free anesthesia, Opioid based Anesthesia
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Unai Ortega Mera
Obesity, Bariatric Surgery Candidate
Modulation of the Inflammatory Response in Bariatric Surgery
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with…
- Conditions
- Obesity, Bariatric Surgery Candidate, Inflammation, Postoperative Pain
- Trial name
- MRICBx3 (NCT06915558)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Intravenous Anesthesia (OBA-IV), Opioid-Based Inhalational Anesthesia (OBA-Inh)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital HM Nou Delfos
Postoperative Pain Intensity
Effect of Opioid-Free Versus Opioid-Based Anesthesia in Discectomy Surgery
This prospective randomized double-blind clinical trial compares opioid-free anesthesia (OFA) versus opioid-based anesthesia (OBA) on postoperative analgesia in patients undergoing elective lumbar discectomy surgeries at Zagazig…
- Trial name
- NCT07787858
- Testing
- Dexmedetomidine and Ketamine-based Opioid-free Anesthesia, Fentanyl-based Opioid Anesthesia
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Zagazig University
Anesthesia
Melatonin in Obese Patients in Laparoscopic Cholecystectomy
Opioid free anesthesia (OFA) means a technique in which no intraoperative opioid is administered through any route. Perioperative pain management in an obese patient is challenging.
- Trial name
- NCT06355687
- Testing
- Melatonin, Vitamin Supplement
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Opioid Use, Postoperative Pain
Opioid Free Anesthesia and Major Spine Surgery
This study compares the intraoperative opioid free anesthesia approach in multilevel spine posterior instrumentation surgery to a conventional opioid-based anesthesia.
- Conditions
- Opioid Use, Postoperative Pain, Spine Disease
- Trial name
- NCT03417193
- Testing
- opioid free Anesthesia vs Opioid based Anesthesia
- Where
- Lebanon
- Volunteers
- 48 people
- Sponsor
- Lebanese American University
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Primary Total Hip Arthroplasty
Opioid Free Anesthesia in Total Hip Arthroplasty
Total hip arthroplasty (THA) is one of the most common orthopedic surgical procedure and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- OFATHA (NCT05072704)
- Testing
- Sufentanil, Dexmedetomidine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CMC Ambroise Paré
Opioid Use, Postoperative Pain
Opioid Free Anesthesia in Bariatric Surgery
This study compares the intraoperative opioid free anesthesia approach in laparoscopic bariatric surgery to a conventional opioid- based anesthesia.
- Conditions
- Opioid Use, Postoperative Pain, Postoperative Nausea and Vomiting, Bariatric Surgery Candidate
- Trial name
- NCT03507634
- Testing
- Opioid free Anesthesia dexmedetomidine and lidocaine, Opioid based anesthesia Fentanyl and Remifentanyl
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- Lebanese American University
Intraoperative Bleeding
The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.
Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of…
- Trial name
- NCT06427707
- Testing
- Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Thoracic, Surgery
Opioid-free Anesthesia in Thoracic Surgery
No study has been conducted to demonstrate the feasibility and safety of an Opioid-Free Anesthesia (OFA) protocol compared to Opioid-Based Anesthesia (OBA) in thoracic surgery, at risk for intense post-operative pain, to improve…
- Trial name
- VATOFA (NCT04246099)
- Testing
- Post-operative care
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Laparoscopic Cholecystectomy
Comparative Study of Opioid-Free Anesthesia Versus Opioid Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is an effective surgical approach for the treatment of gallbladder disorders such as cholecystitis, gallbladder stones or gallbladder polyps.
- Trial name
- NCT06736496
- Testing
- Nalbuphine, Dexmedetomidine
- Volunteers
- 100 people
- Sponsor
- Assiut University
Analgesics, Opioid, Anesthesia; Adverse Effect
Comparison of Total Intravenous Anesthesia and Inhalational Anesthesia in Opioid-Free Anesthesia for Bariatric Surgery: A Randomized Controlled Trial
Total intravenous general anesthesia and combined general anesthesia are recognized methods used during anesthesia. They allow you to effectively control pain and reduce the number of complications associated with taking large…
- Trial name
- NCT06390046
- Testing
- TIVA versus Inhalation
- Where
- Poland
- Volunteers
- 280 people
- Sponsor
- Jagiellonian University
Opioid-Free Anesthesia, Elective Laparoscopic Cholecystectomy
Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic .
1. To evaluate the efficacy of a standardized multimodal Opioid Sparing (OS) protocol versus conventional opioid-based analgesia in reducing acute postoperative 2.
- Trial name
- OFA (NCT07306910)
- Testing
- opoid free anesthesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bariatric Surgery Candidate
Effect of Opioid Free Versus Opioid-Based Anesthesia on Cerebral Oximetry In Gastric Sleeve Operation
Obesity and pneumoperitoneum in the reverse-Trendelenburg position during laparoscopic sleeve gastrectomy (LSG) are reported to negatively affect cerebral oxygenation.
- Trial name
- NCT05146232
- Testing
- induction of anesthesia, maintainance of anesthesia, monitoring
- Volunteers
- 80 people
- Sponsor
- Tanta University
Postoperative Quality of Recovery
Opioid Free Anesthesia and Bariatric Surgery
The morbidly obese bariatric surgery population is susceptible to opioid-induced complications such as respiratory depression and postoperative nausea and vomiting.
- Trial name
- NCT04144153
- Testing
- Opioid Free Total Intravenous Anesthesia, Total Intravenous anesthesia with opioid
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Northwell Health
Opioid Use
Opioid Free Anaesthesia Versus Opioid Based Anesthesia for Laparscopic Cholecystectomy
The aim of this study is to compare the efficacy of Opioid-free anesthesia (OFA) with opioid anaesthesia (OA) in patients undergoing laparoscopic cholecystectomy (LC).
- Trial name
- NCT06231992
- Testing
- opioid anaesthesia, Opioid free anaesthesia
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University