Clinical trials: Opioid-Induced Disorders
Opioid-use Disorder
Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)
Through CTN-0076-Ot (Clinical Decision Support for Opioid Use Disorders in Medical Settings: Pilot Usability Testing in an EMR (COMPUTE)), our team has iteratively developed and piloted a web-based and electronic health record…
- Trial name
- NCT04198428
- Testing
- Opioid Wizard
- Where
- 3 sites in United States
- Volunteers
- 10,891 people
- Sponsor
- HealthPartners Institute
Opioid Safety, Prescription Opioid Misuse
A Patient-Centered Intervention to Improve Opioid Safety
This is a randomized controlled trial of a multifaceted intervention designed to improve the safety of opioid prescribing. The specific aims of this study are to: (a) evaluate whether a multifaceted intervention (Improving the…
- Conditions
- Opioid Safety, Prescription Opioid Misuse, Chronic Pain
- Trial name
- ISOP (NCT02791399)
- Testing
- ISOP Intervention with the Nurse Care Manager
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- VA Office of Research and Development
Opioid-Related Disorders
Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings
In preparation for a large-scale randomized controlled trial (RCT) of Vivitrol® effectiveness in drug courts, investigators propose a feasibility study in the Wake County, North Carolina drug court, where an estimated 50% of…
- Trial name
- DC (NCT02978417)
- Testing
- Naltrexone for extended-release injectable suspension, Oral naltrexone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Healthy Volunteer, Opioid-use Disorder
Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder
The primary objectives for the study are: Part I and Part II: Assess safety and tolerability of repeated doses of INDV-2000 in healthy volunteers.
- Trial name
- NCT04976855
- Testing
- INDV-2000, SUBOXONE® sublingual film
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Opioid Use Disorder
A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.
This is a Phase 1, single-centre, randomized, double-blind, placebo-controlled, 2 fixed sequences, multiple dose study in healthy male and/or female recreational opioid users.
- Trial name
- NCT05587998
- Testing
- Morphine, AZD4041
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Generalized Anxiety Disorder, Comorbid Opiate Dependence in Remission
Anxiety in Recovering Opiate Dependence
This is a 16 week study of the efficacy of quetiapine in treating symptoms of generalized anxiety disorder (GAD) in subjects with comorbid opiate dependence.
- Conditions
- Generalized Anxiety Disorder, Comorbid Opiate Dependence in Remission, Status Post Methadone-Maintenance Treatment
- Trial name
- NCT00668265
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Medical Center
Adherence, Depression
Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1
Patients with HIV, depression, and opioid-dependence are at high risk for poor health outcomes. This is a two-arm randomized controlled trial of cognitive-behavioral therapy for depression and HIV medication adherence in patients…
- Conditions
- Adherence, Depression, Heroin Dependence, Methadone
- Trial name
- NCT00218634
- Testing
- CBT-AD, ETAU
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Massachusetts General Hospital
Opioid-use Disorder
Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone
This study compares two methods of initiating treatment with extended-release naltrexone (XR-NTX) when implemented at community-based inpatient or residential programs.
- Trial name
- SWIFT (NCT04762537)
- Testing
- Standard Induction Procedure (SP), Rapid Induction Procedure (RP)
- Where
- 6 sites in United States
- Volunteers
- 415 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use Disorder
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants
The primary purpose of this study was to assess the safety and tolerability of multiple doses of ASP8062 or placebo alone and in combination with a single dose of morphine.
- Trial name
- NCT04448561
- Testing
- ASP8082, morphine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Drug Interaction, Analgesics
Drug-drug Interaction Study of Lemborexant as an Adjunctive Treatment for Buprenorphine/Naloxone for Opioid Use Disorder
The purpose of this research study is to test the safety, tolerability, drug interactions with buprenorphine-naloxone, and effectiveness lemborexant when used to treat Opioid Use Disorder.
- Conditions
- Drug Interaction, Analgesics, Opioid Use Disorder
- Trial name
- NCT04818086
- Testing
- Lemborexant, Buprenorphine-naloxone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Opioid Abuse
AESOPS Trial 2 (AESOPS-2): Availability of Opioid Harm
The opioid epidemic is the largest man-made public health crisis the United States has faced. The objective of Trial 2 of the Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-2) study, is…
- Trial name
- AESOPS-2 (NCT04758637)
- Testing
- Overdose Notification
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Southern California
Opioid Induced Bowel Dysfunction
Study to Evaluate the Safety and Efficacy of Naldemedine (S-297995) for the Treatment of Opioid-Induced Bowel Dysfunction in Subjects With Chronic Pain
The primary objective of the study is to evaluate the safety of single doses of oral naldemedine in adults physically dependent on opioids.
- Trial name
- NCT01122030
- Testing
- Naldemedine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Shionogi
Opioid Use Disorder, Substance Use Disorder
Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction
Support groups are an important component of addiction treatment, where individuals at more stable stages of their recovery help others by sharing personal experiences.
- Conditions
- Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
- Trial name
- NCT07344233
- Testing
- Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Drug Dependence
Intensive Outpatient Versus Outpatient Treatment With Buprenorphine Among African Americans
The purpose of this study is to compare the effectiveness of different levels of counseling (intensive outpatient versus standard outpatient) on treatment outcomes for African American adult patients receiving buprenorphine in 2…
- Trial name
- NCT01096550
- Testing
- Outpatient, Intensive Outpatient
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Friends Research Institute, Inc.
Moderate or Severe Opioid Use Disorder
A Multiple Dose Opioid Challenge Study
Multi-site, randomized, double-blind, repeat-dose Phase 2 study to evaluate the degree and duration of action of multiple doses of CAM2038 in blocking the effects of hydromorphone in patients with moderate or severe opioid use…
- Trial name
- NCT02611752
- Testing
- CAM2038
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- Braeburn Pharmaceuticals
Opioid-induced Constipation
Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic Procedures
The purpose of this study is to examine the safety and activity of MNTX in relieving opioid-induced constipation following orthopedic procedures.
- Trial name
- NCT00640146
- Testing
- Methylnaltrexone bromide
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Bausch Health Americas, Inc.
Opioid Dependence
Dane County Drug Court Study for Addicted Offenders
The proposed work addresses critical health and public safety issues in the U.S. and in Wisconsin: the intersection of addiction and crime and the prevention of associated individual and public health complications.
- Trial name
- NCT01843751
- Testing
- buprenorphine/naloxone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Opioid-use Disorder
mHealth for Patient Self-Management of Opioid Use Disorder
Twenty individuals diagnosed with opioid use disorder (OUD) will be recruited to participate in a beta test to demonstrate feasibility of using an online tool to help them better self-manage their recovery.
- Trial name
- NCT03633929
- Testing
- KIOS OUD
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Biomedical Development Corporation
Substance Abuse, Chronic Pain
Physician Coaching to Reduce Opioid-related Harms
This project pilot tests an innovative clinical guideline translation and physician coaching model to promote adherence to evidence-based guidelines for the prescribing of opioid pain medications in primary care settings.
- Trial name
- NCT02433496
- Testing
- Physician coaching
- Where
- United States
- Volunteers
- 53,132 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Opioid Overdose
Pharmacokinetic Evaluation of Intranasal Nalmefene Using Three Dosing Regimens
This study is to compare the pharmacokinetics (how the body absorbs, breaks down and eliminates drug from your body) of nalmefene when given as a single dose intranasally (IN;into the nose), as a single dose in each nostril and…
- Trial name
- NCT05219669
- Testing
- Nalmefene Hydrochloride
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Opiant Pharmaceuticals Inc