Clinical trials: Opioid-Induced Hyperalgesia
Pain, Anesthesia
Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients
Purpose: To explore and compare antihyperalgesic effects of butorphanol, flurbiprofen axetil, and a combination of both received before anesthesia induction.
- Trial name
- NCT02043366
- Testing
- Normal Saline, Butorphanol, Flurbiprofen axetil
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Tianjin Medical University General Hospital
Healthy
Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?
The purpose of this study is to examine whether two clinically sensible dose regimen of fentanyl (low dose vs. high dose) lead to different pain scores as measured by the nonverbal rating scale (NRS) in healthy volunteers at 4.5…
- Trial name
- FentaOIH-V (NCT02252458)
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Buprenorphine, Pain
The Effects of Opioid Taper on Opioid-Induced Hyperalgesia
Evidence to support the effectiveness of ongoing opioid therapy for the treatment of chronic non-malignant pain is lacking. In fact, data suggest that patient outcomes improve when tapered off opioid analgesics.
- Trial name
- NCT03063905
- Testing
- Buprenorphine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Georgetown University
Chronic Low Back Pain, Opioid-induced Hyperalgesia
Opiate-Induced Tolerance & Hyperalgesia in Pain Patients
Opiates such as morphine are the cornerstone medications for the treatment of moderate to severe pain. Recent evidence suggests that pain patients on chronic opioid therapy become more sensitive to pain (hyperalgesia) over time.
- Trial name
- NCT00246532
- Testing
- Morphine
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Patients Undergoing Laparoscopic Gastrectomy
Effect of Nefopam on Remifentanil Induced Postoperative Hyperalgesia
Opioids has been reported to cause hyperalgesia. Opioid induced hyperalgesia (OIH) is defined as paradoxically lowering the threshold of pain after the exposure of opioid.
- Trial name
- NCT01732666
- Testing
- Nefopam, low dose remifentanil, high dose remifentanil
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Hyperalgesia, Opioid-Related Disorders
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia
Remifentanil is a potent opioid widely used during the administration of general anesthesia. There is a lot of evidence that suggest that the used of remifentanil is associated with the development of hyperalgesia (a reduction of…
- Trial name
- NCT02992938
- Testing
- Acetazolamide
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- University of Chile
Acute Nociceptive Pain, Hyperalgesia
Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults
Prospective, randomized, placebo-controlled, double-blinded, crossover study to investigate the effect of cannabidiol (CBD) on remifentanil-induced hyperalgesia in healthy volunteers in a well-established acute pain model.
- Conditions
- Acute Nociceptive Pain, Hyperalgesia, Allodynia, Opioid-induced Hyperalgesia
- Trial name
- CANAB II (NCT04059978)
- Testing
- CBD, Remifentanil
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain, Chronic Pain
Effect of Ketamine on Opioid-Induced Hyperalgesia
The purpose of this study is to compare pain threshold, pain tolerance, and wind up, as measured by QST, before and after a single dose of ketamine infusion under two clinical conditions: chronic pain patients on opioid therapy…
- Conditions
- Pain, Chronic Pain, Hyperalgesia
- Trial name
- NCT00833755
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Massachusetts General Hospital
Hyperalgesia
Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end…
- Trial name
- 0813 (NCT00991809)
- Testing
- Alfentanil, Diphenhydramine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Dependence, Pain
The Effects of Minocycline in Opioid-maintained Patients
Opioids are the most commonly utilized pharmacological treatment for moderate to severe pain. However, their clinical value is hindered by the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT02359006
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Yale University
Hyperalgesia
Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol
Opioid Induced Hyperalgesia (OIH) is an entity than has been demonstrated in healthy volunteers and in animal models. Is defined as an increase in the perception to painful stimuli, increasing the opioid requirements and…
- Trial name
- NCT02934763
- Testing
- Propranolol, Saline
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Tooth Extractions
Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery
Wisdom teeth removal under general anaesthesia is usually suitable for ambulatory surgery. The choice of opioid in dental day surgery is based on the need for a rapid and full recovery, as well as less morphine administration.
- Trial name
- SUF-REM-DDS (NCT01139671)
- Testing
- Remifentanil
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Hyperalgesia
Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids
To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group…
- Trial name
- NCT05234697
- Testing
- Remifentanil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Ehlers-Danlos Syndrome, Craniocervical Syndrome
Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT).
- Trial name
- NCT04437589
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Servei Central d'Anestesiologia
Cancer Patients
A Comparison of the Perception of a Needle Injection Pain Between Cancer Patients Receiving Opioid Therapy Versus Opioid-naive Patients
Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids. In humans, the evidence of OIH is strong but conflicting.
- Trial name
- NCT01704469
- Testing
- The local anesthetic injection
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Neuropathic Pain
Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica
Clinical, psychophysical, behavioral or genetic factor will predict the response to opioid treatment in patients with chronic neuropathic pain.
- Trial name
- NCT01914042
- Testing
- Morphine, Milnacipran
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rambam Health Care Campus