Clinical trials: Opioid-Related Disorders
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Opiate Dependence, Chronic Pain
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
This study is designed to develop an effective psychotherapy for chronic pain and opioid dependence.
- Trial name
- POD (NCT00634803)
- Testing
- CBT, Buprenorphine, Educational Counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Opioid-Related Disorders
Neurofeedback in Individuals With Substance Use Disorders
The aim of this study is to train individuals with opioid use disorder to control their brain activity in a way that has been associated with their symptoms.
- Trial name
- NCT04188288
- Testing
- Experimental feedback, Control feedback, fMRI
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Opioid Dependence
Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments
This study will compare the effects of brief strengths-based case management (SBCM) to the effects of screening, assessment and referral alone (SAR) in opioid-dependent patients.
- Trial name
- NCT02586896
- Testing
- Strengths-based Case Management (SBCM), Screening, Assessment, and Referral (SAR)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- NYU Langone Health
Addiction, Opioid Use
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
The overall goal of this project is to collect initial human data on the effects of novel compounds on safety (interactions with an opioid drug, e.g., buprenorphine) and early efficacy signals (subjective effects on negative…
- Conditions
- Addiction, Opioid Use, Substance Use Disorders, Opioid Use Disorder
- Trial name
- NCT05976646
- Testing
- Auvelity
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Opioid Medication Assisted Treatment
Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment
Opioid use disorder (OUD) is a major cause of illness and death among Veterans for which effective treatment is a major priority of the Veterans Health Administration (VHA).
- Trial name
- CONDUIT (NCT04178551)
- Testing
- Implementation Facilitation
- Where
- 11 sites in United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder
A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail
The purpose of this study is to determine which of three approaches started in jail is more effective in treating opioid use disorder: (1) methadone treatment without counseling (termed interim methadone) coupled with case…
- Trial name
- SOMATICS FRI (NCT02334215)
- Testing
- Methadone, Patient Navigation, Enhanced Treatment as Usual (ETAU)
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Friends Research Institute, Inc.
Opioid Abuse
Community Trial in the Cherokee Nation
The target population is students attending high schools in small rural towns in the 14 counties that partially or fully fall within the Cherokee Nation reservation.
- Trial name
- NCT04839978
- Testing
- Connect Program, Communities Mobilizing for Change and Action (CMCA)
- Where
- United States
- Volunteers
- 919 people
- Sponsor
- Emory University
Healthy Volunteer, Opioid-use Disorder
Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder
The primary objectives for the study are: Part I and Part II: Assess safety and tolerability of repeated doses of INDV-2000 in healthy volunteers.
- Trial name
- NCT04976855
- Testing
- INDV-2000, SUBOXONE® sublingual film
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Opioid-use Disorder
Evaluation of Doxazosin to Alter the Abuse of Oxycodone
Healthy, adult men and women, aged 21 to 59 years, who abuse opioids and are physically dependent on them will be recruited to participate in a study to examine the ability of doxazosin, an epinephrine receptor blocker, to alter…
- Trial name
- NCT03415581
- Testing
- Intranasal Oxycodone, Cue Session
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission
KAP for Depression in Abstinent Opioid Users
The purpose of the study is to examine whether an investigational medication called ketamine along with psychotherapy is an effective treatment for depression in participants with a history of opioid addiction who have not abused…
- Conditions
- Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission, Major Depressive Disorder
- Trial name
- KReDO (NCT05193318)
- Testing
- Ketamine-assisted psychotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid-use Disorder, Opioid-Related Disorders
Substance Use Treatment and Recovery Team
This study is a multi-site, randomized pragmatic trial being conducted at three diverse sites. The study, called the Substance Use Treatment and Recovery Team (START), will evaluate whether a collaborative care team increases the…
- Trial name
- START (NCT05086796)
- Testing
- Substance Use Treatment and Recovery Team (START)
- Where
- 3 sites in United States
- Volunteers
- 325 people
- Sponsor
- Cedars-Sinai Medical Center
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
HIV, Hepatitis C
Ending Transmission of HIV, HCV, and STDs and Overdose in Rural Communities of People Who Inject Drugs (ETHIC)
This study will evaluate the referral to harm reduction services (HRS) including syringe services, naloxone overdose prevention, substance use treatment referral, HIV, HCV, and STD testing and referral and linkage to care through…
- Conditions
- HIV, Hepatitis C, Opioid-use Disorder, Injection Drug Use
- Trial name
- ETHIC (NCT04427202)
- Testing
- Referral to harm reduction services
- Where
- 2 sites in United States
- Volunteers
- 306 people
- Sponsor
- University of Chicago
Opioid-use Disorder
Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.
The purpose of this 24-week study is to evaluate the impact of recovery coach intervention on rates of treatment retention, illicit opioid use, and readmission among hospitalized patients newly initiated on buprenorphine or…
- Trial name
- ISTOP (NCT03212794)
- Testing
- Recovery coach
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Opioid-use Disorder
Mindful Moms in Recovery
The purpose of this study is to evaluate the initial efficacy of a yoga-mindfulness intervention to promote ongoing recovery for pregnant and parenting women with Opioid Use Disorder (OUD) receiving perinatal services and…
- Trial name
- MMORE (NCT04584502)
- Testing
- Mindful Moms Yoga Mindfulness Intervention
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Trustees of Dartmouth College
Opioid-use Disorder
Cannabidiol Use to Reduce Cravings in Individuals With Opioid Use Disorder on Buprenorphine
The purpose of this week-long study is to determine the impact of cannabidiol on cue-induced cravings among individuals with opioid use disorder who are stable on sublingual buprenorphine treatment.
- Trial name
- CURB (NCT04192370)
- Testing
- Cannabidiol 600mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Brigham and Women's Hospital
HIV, AIDS
Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations
Specific Aim: To conduct a randomized, placebo-controlled trial of extended release-naltrexone (XR-NTX) among Human Immunodeficiency Virus (HIV) infected prisoners meeting Diagnostic Statistical Manual IV (DSM-IV) criteria for…
- Conditions
- HIV, AIDS, Opioid Dependence, Drug Dependence
- Trial name
- NewHope (NCT01246401)
- Testing
- Extended-Release Naltrexone
- Where
- 3 sites in United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University