Clinical trials: Opioid-Use Disorder (OUD)
Opioid Use Disorder
Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study
This study proposes to examine the safety, tolerability, and pharmacokinetics (PK) of NYX-783 50 mg and 150 mg versus Placebo (PBO) in combination with acute Oxycodone 15 mg and 30 mg in an inpatient randomized, cross-over study…
- Trial name
- NCT05447286
- Testing
- NYX-783, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use Disorder
Piloting a Web Resource for Pregnancy OUD in Jail
The goal of this clinical trial is to pilot an adaptable, user-friendly, web-accessible toolkit and implementation strategy for jails to be able to provide access to pregnancy-specific opioid use disorder (OUD) care.
- Trial name
- NCT05853289
- Testing
- Maternal Opioid use Disorder Management and Care Resources (MOM CARE) in Custody
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Opioid Use Disorder, Bloodstream Infection
Retention and Re-Engagement in Treatment for Addiction Following Serious Injection Related Infections (RETAIN)
This project is a pilot study of an adapted intervention of an existing Opioid Use Disorder (OUD) treatment retention intervention called Recovery Management Checkups (RMC).
- Conditions
- Opioid Use Disorder, Bloodstream Infection, Osteomyelitis, Endocarditis
- Trial name
- RETAIN (NCT06489535)
- Testing
- RETAIN, Unrelated videos
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Sleep Disorder, Restless Legs Syndrome
Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD
The investigators propose to test the use of pramipexole in patients being treated for Opioid Use Disorder to test its ability to reduce symptoms of both Restless Legs Syndrome and protracted opioid withdrawal and thereby promote…
- Conditions
- Sleep Disorder, Restless Legs Syndrome, Opioid-use Disorder, Opioid Withdrawal
- Trial name
- NCT04759703
- Testing
- Pramipexole
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Opioid-use Disorder
Recovery Management Checkups for Opioid Use Disorder Experiment
The experiment will be conducted in collaboration with 6 jails representing discrete geographic counties in Illinois and the opioid treatment providers (OTP) that serve them.
- Trial name
- JCOIN-HUB (NCT04365920)
- Testing
- Recovery Management Checkups (RMC), RMC-Adaptive
- Where
- United States
- Volunteers
- 455 people
- Sponsor
- Chestnut Health Systems
Opioid-use Disorder, Recidivism
Fostering MAT Use in Justice Populations
The grant will test two timely and successful evidence-based implementation practices, NIATx Coaching and ECHO, with jail/community-based healthcare providers to increase medication assisted treatment (MAT) use with justice…
- Trial name
- NCT04363320
- Testing
- NIATx Coaching, ECHO
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Wisconsin, Madison
Opioid Use Disorder
Low-dose Versus a High-dose Sublingual Buprenorphine Induction
This study proposes to compare a low-dose versus a high-dose buprenorphine induction scheme in 40 fentanyl using people with Opioid Use Disorder (OUD).
- Trial name
- NCT05944952
- Testing
- buprenorphine/naloxone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Opioid Use Disorder (OUD), Chronic Pain
Mindfulness Texting for Medication Adherence and Chronic Pain Management
The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages based on integrated Acceptance and Commitment Therapy and Mindfulness Based Relapse Prevention (ACT+MBRP) on medication adherence…
- Trial name
- MiMA (NCT07711795)
- Testing
- Mindfulness text messages
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of New Mexico
Opioid-use Disorder, Pain
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)
The purpose of this pilot trial is to determine the feasibility of integrating exercise and psychotherapy that is specifically targeted to reducing and managing pain into residential drug treatment programs.
- Trial name
- NCT04736550
- Testing
- Exercise, Psychotherapy for Pain (I-STOP)
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Case Western Reserve University
Opioid Use Disorder, Sleep
The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
Opioid use disorder (OUD) is a chronic relapsing disorder and is well-known for its high-risk rate of overdoses and death. In OUD, sleep and circadian disruptions are highly prevalent, interfere with opioid maintenance treatment…
- Conditions
- Opioid Use Disorder, Sleep, Circadian Rhythms, fMRI Research
- Trial name
- NCT06832007
- Testing
- AYO light glasses (experimental), AYO light glasses (comparator)
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Opioid Use Disorder (OUD), Chronic Pain
Addiction Treatment in Primary Care Expansion
The Veterans Health Administration (VA) is a national leader in addressing the twin epidemics of chronic pain and opioid use, misuse, and opioid use disorder (OUD); but important challenges remain.
- Trial name
- APEX (NCT03547882)
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder
Olanzapine in OUD Patients
This study is designed to examine whether olanzapine (2.5 to 20mg/day) impacts opioid use in patients with opioid use disorder and comorbid SMI symptoms who are taking buprenorphine-naloxone.
- Trial name
- NCT05179772
- Testing
- Olanzapine
- Where
- 2 sites in United States
- Sponsor
- University of Pennsylvania
Stress Disorders, Post-Traumatic, Opioid Use Disorder
MDMA for Co-occurring PTSD and OUD After Childbirth
This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD).
- Trial name
- NCT05219175
- Testing
- MDMA Assisted Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Opiod Use Disorder
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System
This study, called the Chicago Data-driven Opioid use disorder Screening, Engagement, Treatment and Planning (C-DOSETaP) System, tests a new system of clinical care for patients with opioid use disorder (OUD) across a large…
- Trial name
- C-DOSETaP (NCT07498322)
- Testing
- OUD screening, MOUD, Continuity of care
- Where
- United States
- Volunteers
- 271,031 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Opioid Use, Opioid Abuse
Rural Expanded Access to OUD Care & Linkage Using Toxicologists for Telehealth Initiated Treatment
The overarching goal of this project is to increase the availability of OUD treatment in rural counties in the state of Georgia by using Emergency Department (ED)-based telehealth strategies to initiate MOUD and connect patients…
- Trial name
- REAL TTIME (NCT05711056)
- Testing
- Sociobehavioral Intervention
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Emory University
Community Reinforcement And Family Training, Family Health
Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to develop and evaluate the technical feasibility and commercial viability of a scalable digital counselor training program for CRAFT.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT05875142
- Testing
- Behavioral: Digital Tutorial Overview, Behavioral: Training Materials, Behavioral: Feedback and Coaching
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Perinatal Opioid Use Disorder, Opioid Use Disorder
Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT
To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by women who are pregnant and…
- Trial name
- PENNY-COPILOT (NCT06969261)
- Testing
- Penny COPILOT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Opioid Use, Opioid-use Disorder
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
This study integrates the Mental Health Research Network (MHRN) suicide risk models into Opioid Wizard, an electronic health record (EHR) clinical decision support (CDS) to identify and treat patients at high risk of opioid use…
- Conditions
- Opioid Use, Opioid-use Disorder, Suicide
- Trial name
- NCT04939727
- Testing
- OUD-CDS + Suicide Risk Model associated CDS
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- HealthPartners Institute
Opioid-use Disorder, HIV Infections
Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT) Program for Opioid Dependent Prisoners and Probationers Transitioning to the Community
The purpose of this study is to evaluate the efficacy a Screening, Brief Intervention, and Referral to Treatment (SBIRT) program for linking opioid dependent individuals currently incarcerated or in probation in Moldova…
- Conditions
- Opioid-use Disorder, HIV Infections, Tuberculosis, Hepatitis C
- Trial name
- MATLINK (NCT04947475)
- Testing
- SBIRT
- Where
- 3 sites in Kyrgyzstan, Moldova and 1 more
- Volunteers
- 835 people
- Sponsor
- Yale University