Clinical trials: Opioid-related Disorders
Opioid Use Disorder, Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 1
This study is stage 2, round 1 of a larger study which refines and optimizes the EMBED clinical decision support (CDS); see NCT03658642 to increase number of ED physicians following standard of care for the administration of…
- Trial name
- NCT07549126
- Testing
- Nurse prompt to complete COWS under required documentation, Refined EMBED CDS
- Where
- 3 sites in United States
- Volunteers
- 267 people
- Sponsor
- Yale University
Neonatal Abstinence Syndrome
Buprenorphine for the Treatment of Neonatal Abstinence Syndrome
Neonatal abstinence syndrome is a disease that affects children who were exposed to opioid drugs prior to birth. Commonly used treatments at present include morphine or tincture of opium.
- Trial name
- NCT00521248
- Testing
- buprenorphine, Oral morphine solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Opioid Use Disorder
Virginia Opioid Overdose Treatment InitiatVE
This is a Phase 3b, open-label study in patients that present to the ED for an opioid OD and receive treatment with an opioid antagonist.
- Trial name
- VOTIVE (NCT03818399)
- Testing
- SUBLOCADE
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Virginia Commonwealth University
Opioid-Related Disorders, Substance-Related Disorders
Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 7
The purpose of this study is to determine the safety of lofexidine in the treatment of opiate withdrawal. Preliminary data will also be obtained to assess the ability of lofexidine to alleviate opiate withdrawal signs and…
- Trial name
- NCT00000358
- Testing
- Lofexidine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Related Disorder, Drug Overdose
The ENHANCE Project Toolkit
This study will examine the feasibility, appropriateness, and acceptability of a bundle of smartphone-based tools for lowering overdose risk. 40 participants will be enrolled and can expect to be on study for up to 9 months.
- Conditions
- Substance Related Disorder, Drug Overdose, eHealth
- Trial name
- NCT07649278
- Testing
- Connections mHealth Application
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Opioid-induced Constipation, Cancer
Study of Opioid-Induced Constipation 2 Project
The aim of the project is to investigate OIC in a real world / diverse group of patients with cancer. The objectives of the project are to determine: a) efficacy of a treatment algorithm to manage OIC; b) efficacy of conventional…
- Conditions
- Opioid-induced Constipation, Cancer, Cancer Pain
- Trial name
- StOIC-2 (NCT04404933)
- Testing
- Treatment algorithm for OIC
- Where
- 16 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Opioid Dependence
The German Project of Heroin Assisted Treatment of Opiate Dependent Patients
The study will test the hypotheses that heroin assisted treatment, compared to methadone maintenance treatment, is more effective with regard to the improvement of health, reduction of illicit drug consumption, decrease of…
- Trial name
- NCT00268814
- Testing
- Diacetylmorphine, Psycho-education and Counselling, Methadone
- Where
- 7 sites in Germany
- Volunteers
- 1,015 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Opioid-induced Constipation
Long Term Safety of Naldemedine
The purpose of this study is to evaluate the long-term safety of naldemedine for the treatment of constipation due to opioid therapy.
- Trial name
- NCT01965652
- Testing
- Naldemedine
- Where
- 186 sites in United States, Australia and 14 more
- Volunteers
- 1,246 people
- Sponsor
- Shionogi
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for inpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032955
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in United States
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Maternal Opioid Use Disorder, Opioid Exposed Infant
Maternal Buprenorphine-naloxone Treatment and the Infant
The purpose of this mechanistic study is to evaluate the effects that maternal buprenorphine-naloxone maintenance have on the neurobehavioral development of the fetus and infant.
- Trial name
- NCT03291847
- Testing
- fetal monitoring, Buprenorphine Naloxone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder
Dynamic Treatment Regimes for Opioid Use Disorder
This study aims to develop and evaluate dynamic treatment regimes (DTRs) to improve personalized care for individuals with opioid use disorder (OUD).
- Trial name
- NCT07011758
- Testing
- Medication for opioid use disorder, psychotherapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
HIV Infections, Opioid-Related Disorders
SIRI Checklist: An Integrated Hospital Model to Optimize HIV Prevention in Persons Who Inject Drugs
The purpose of this study is to develop and test a serious injection-related injections (SIRI) checklist aimed at increasing evidence-based treatment for rural people who use drugs (PWUD) including innovative, long-acting…
- Conditions
- HIV Infections, Opioid-Related Disorders, Pre-Exposure Prophylaxis (PrEP)
- Trial name
- SHAPE (NCT05480956)
- Testing
- SIRI Checklist, Enhanced Peer Recovery Coach, SIRI Checklist + Enhanced Peer Recovery Coach
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Opioid Overdose
A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose
Opioids are responsible for the greatest drug-related global health burden. Prevention and treatment programs for people with opioid use disorder are widely implemented, but further actions are required to reduce the mortality…
- Trial name
- RESPONDER (NCT07079241)
- Testing
- Naloxone-responder: A volunteer first responder system connected to emergency dispatch service and alerting overdose and first aid educated volunteers with naloxone to suspected opioid overdoses
- Where
- Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Region Skane
Addiction, Opioid Dependence
Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction
The purpose of this study is determine the safety, efficacy and tolerability of a novel drug APH-1501 as a pharmacotherapy for Opioid Dependence. The investigators will evaluate the safety of escalating doses APH-1501.
- Conditions
- Addiction, Opioid Dependence, Opioid Withdrawal
- Trial name
- NCT03813095
- Testing
- APH-1501
- Volunteers
- 32 people
- Sponsor
- Aphios
Opioid Use Disorder
Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment
The goal of this clinical trial is to learn if receiving peer recovery support (support services provided by trained "peers" with lived experience of addiction and recovery) improves retention in medication treatment among people…
- Trial name
- PEERS (NCT07197801)
- Testing
- Peer recovery support to enhance patient engagement in medication for opioid use disorder treatment
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Geisinger Clinic
Opioid-use Disorder
Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)
Through CTN-0076-Ot (Clinical Decision Support for Opioid Use Disorders in Medical Settings: Pilot Usability Testing in an EMR (COMPUTE)), our team has iteratively developed and piloted a web-based and electronic health record…
- Trial name
- NCT04198428
- Testing
- Opioid Wizard
- Where
- 3 sites in United States
- Volunteers
- 10,891 people
- Sponsor
- HealthPartners Institute
Heroin Dependence
University of Houston Drug Abuse Research Development Program II
The study is examining the impact of a Virtual Reality Cue Exposure Therapy intervention on heroin cravings compared to Relapse Prevention Drug Education.
- Trial name
- UHDARDP-II (NCT03557632)
- Testing
- Virtual Reality Cue Exposure Therapy, Relapse Prevention Drug Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Houston
Opioid-related Disorders
BUPrenorphine Facilitated Access and Supportive Treatment --AIM 3
The goal of this study is to test whether peer mentors (i.e., individuals with past opioid addiction and prior incarceration) can facilitate entrance into buprenorphine (Suboxone) treatment for individuals with opioid use…
- Trial name
- BUPFAST (NCT02902835)
- Testing
- BUP_FAST, Referral to treatment
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder
Evaluation of the Interactions of Cannabidiol (CBD) With Morphine
The purpose of this study is to analyze drug-drug interactions of CBD on co-administered Morphine as first step in understanding CBD-opioid interactions.
- Trial name
- NCT05143424
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-induced Constipation (OIC)
A Study to Assess the Safety, Tolerability and Clinical Activity of TD-1211 in Patients With Opioid-Induced Constipation
A dose-escalation study to assess the safety, tolerability and clinical activity of TD-1211 in patients with opioid-induced constipation.
- Trial name
- NCT01333540
- Testing
- TD-1211
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Glycyx Therapeutics