Clinical trials: Opioids
Opioid-Related Disorders
Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users
To determine the relative abuse potential of VYCAVERT (hydrocodone bitartrate and acetaminophen) compared to GENERIC H/A (hydrocodone bitartrate and acetaminophen) when crushed and administered intranasally to non dependent…
- Trial name
- NCT01759446
- Testing
- Generic H/A taken first, Vycavert taken first, Generic H/A plus i taken first
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
Sleep Disorder, Restless Legs Syndrome
Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD
The investigators propose to test the use of pramipexole in patients being treated for Opioid Use Disorder to test its ability to reduce symptoms of both Restless Legs Syndrome and protracted opioid withdrawal and thereby promote…
- Conditions
- Sleep Disorder, Restless Legs Syndrome, Opioid-use Disorder, Opioid Withdrawal
- Trial name
- NCT04759703
- Testing
- Pramipexole
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Marijuana Usage, Opioid Use
Opioid and Cannabinoid Interactions
This study will examine the effects of doses of marijuana/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other…
- Trial name
- NCT03705559
- Testing
- Vaporized Marijuana, Opioid Agonist
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shanna Babalonis, PhD
Opioid Use Disorder, Infectious Disease
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations
This is a 5-year Hybrid Type 1 Effectiveness-Implementation Randomized Control Trial (RCT) that compares two models of linking and retaining individuals recently released from justice involvement to the continuum of…
- Conditions
- Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use
- Trial name
- ACTION (NCT05286879)
- Testing
- Patient Navigator, Mobile Health Unit
- Where
- 3 sites in United States
- Volunteers
- 601 people
- Sponsor
- Yale University
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Moderate to Severe Pain Due to Diabetic Polyneuropathy
A Study to Demonstrate the Analgesic Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Addition to Pregabalin Compared to Pregabalin Alone in Opioid-naïve Subjects Treated With Pregabalin Suffering From Moderate to Severe Pain Due to Diabetic Polyneuropathy
To show superior analgesic efficacy of OXN PR in addition to a patient's current dose of pregabalin compared to pregabalin alone.
- Trial name
- NCT00944697
- Testing
- Oxycodone Naloxone
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Opioid Use Disorder
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants
The primary purpose of this study was to assess the safety and tolerability of multiple doses of ASP8062 or placebo alone and in combination with a single dose of morphine.
- Trial name
- NCT04448561
- Testing
- ASP8082, morphine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Chronic Pain
Open-Label Safety and Tolerability of Oxymorphone IR and ER in Opioid Tolerant Pediatric Subjects
Patients will convert from current opioid to Oxymorphone ER and undergo titration. During the Titration Period, subjects will receive daily oxymorphone Extended Release tablets(s) every 12 hours.
- Trial name
- NCT00765856
- Testing
- Oxymorphone ER
- Where
- 13 sites in United States
- Volunteers
- 27 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Adolescent Idiopathic Scoliosis
Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion
Prospective, randomized control trial To determine if oral caffeine decreases the frequency of opioid demand in children with adolescent idiopathic scoliosis after their spinal fusion surgery To compare pain scale ratings, number…
- Trial name
- NCT04950660
- Testing
- Caffeine Tablet
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Children's Mercy Hospital Kansas City
Opioid-use Disorder
Lofexidine for Management of Opioid Withdrawal With XR-NTX Treatment
This is an open-label pilot trial to evaluate the safety and tolerability of lofexidine in the management of opioid withdrawal symptoms while initiating outpatient treatment with naltrexone.
- Trial name
- NCT04056182
- Testing
- Lofexidine 0.18 MG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Opioid-related Disorders
Abuse Liability of Suboxone Versus Subutex
The study is designed to compare the abuse liabilities of intravenous buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT00710385
- Testing
- Heroin, Naloxone, Low Bup Dose
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Induced Bowel Dysfunction
Study to Evaluate the Safety and Efficacy of Naldemedine (S-297995) for the Treatment of Opioid-Induced Bowel Dysfunction in Subjects With Chronic Pain
The primary objective of the study is to evaluate the safety of single doses of oral naldemedine in adults physically dependent on opioids.
- Trial name
- NCT01122030
- Testing
- Naldemedine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Shionogi
HIV Prevention, Opioid-Related Disorders
Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1
Much of the HIV/AIDS epidemic is driven by transmission from or to persons addicted to opiates. Many of these individuals pass through a correctional setting each year, creating an opportunity for linkage to substance abuse…
- Trial name
- NCT00142935
- Testing
- Pre-release Initiation of MMT, Post Release Initiation of MMT., Standard of Care Plus
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- The Miriam Hospital
Pain, Opioid Use
Comparison of Quadratus Lumborum Block Types
This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain…
- Conditions
- Pain, Opioid Use, Lumbar Disc Herniation
- Trial name
- NCT04588389
- Testing
- Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Massachusetts, Worcester
Healthy Controls
A Brain Imaging Study of Opioid (Morphine) and Non-opioid (Ketorolac) Conditioning Effects
Healthy right-handed volunteers aged 21 to 50 needed for a research study of the effects of morphine and ketorolac on brain activity in response to pain stimuli as measured by functional Magnetic Resonance Imaging (fMRI) and…
- Trial name
- NCT01576276
- Testing
- Integrated MR-PET scan, Ketorolac
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain, Opiates
Preventing Risky Drinking in Veterans Treated With Prescription Opioids
Veterans who are taking prescription opioids for chronic pain and are engaging in risky drinking are at heightened risk for drug interactions, including overdose and other negative effects, particularly if they are also using…
- Conditions
- Pain, Opiates, Alcohol Drinking
- Trial name
- NCT02709317
- Testing
- Prevention Intervention, Brief Intervention
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Pennsylvania
Opioid-use Disorder
PRimary Care Opioid Use Disorders Treatment (PROUD) Trial
Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDs-buprenorphine and injectable naltrexone-can be prescribed in primary care (PC).
- Trial name
- PROUD (NCT03407638)
- Testing
- PROUD Intervention
- Where
- 6 sites in United States
- Volunteers
- 377,373 people
- Sponsor
- Kaiser Permanente
Opioid-Induced Bowel Dysfunction
Opioid-induced Bowel Dysfunction: Long-Term Assessment of Lubiprostone
The purpose of this study is to evaluate the long-term safety and efficacy of lubiprostone administration in participants with opioid-induced bowel dysfunction.
- Trial name
- NCT00620061
- Testing
- Lubiprostone 24
- Where
- 123 sites in United States, Canada
- Volunteers
- 439 people
- Sponsor
- Sucampo Pharma Americas, LLC
Pain, Opiate Addiction
Methadone Monitoring for Insights Into Adverse Events
Methadone has been an effective and inexpensive therapy in the management of chronic pain and opioid dependence. However it has been associated with sudden, unexpected deaths.
- Trial name
- MEMORIES (NCT01191242)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Intermountain Health Care, Inc.
Opiate Addiction
Onsite Buprenorphine Treatment at Syringe Exchange Programs
This trial will recruit syringe exchange participants with opioid use disorder in New York City and test whether starting buprenorphine treatment at the syringe exchange program is more effective than referral to a community…
- Trial name
- O-BMT (NCT03150173)
- Testing
- Onsite treatment, Enhanced referral, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Montefiore Medical Center
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