Clinical trials: Opioids
Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal
Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome
Randomized pilot trial comparing scheduled morphine dosing with a weaning protocol to intermittent morphine dosing on an as-needed basis for newborns with neonatal abstinence syndrome.
- Conditions
- Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
- Trial name
- NCT04298853
- Testing
- Morphine PRN, Morphine scheduled
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University
Cancer, Pain Management
Smartphone Technology to Alleviate Malignant Pain (STAMP)
The purpose of the study is to develop the STAMP app (Smartphone Technology to Alleviate Malignant Pain). This app will be used by patients with advanced cancer to track symptoms and receive tailored symptom management advice.
- Conditions
- Cancer, Pain Management, Opioid Use
- Trial name
- NCT03717402
- Testing
- Intervention Participants
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Opioid Overdose
Opioid Rapid Response System: Naloxone Training in Communities
The pervasive impact of the opioid epidemic has touched all layers of society for the past two decades, resulting in over 115 deaths daily and imposing annual costs of $78.5 billion.
- Trial name
- NCT06238128
- Testing
- Opioid Rapid Resonse System (ORRS) training, Non-active opioid overdose response training
- Where
- United States
- Volunteers
- 773 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity &Amp; Overweight, General Anesthetic
Postoperative Opioid Consumption in Gastric Sleeve Surgery
The study aimed to compare balanced anesthesia protocols using only opioids as analgesics during induction in gastric sleeve surgery with protocols using opioids and ketamine together in terms of anesthesia management, opioid…
- Conditions
- Obesity &Amp; Overweight, General Anesthetic, Ketamine
- Trial name
- POCiGSS (NCT07135154)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Balikesir University
Opioid-use Disorder
A Pilot Feasibility Study of Mindfulness-Oriented Recovery Enhancement With Pregnant Women With Opioid Use Disorder
Thirty pregnant women with substance use disorder will be recruited to participate in eight sessions of MORE.
- Trial name
- NCT04824521
- Testing
- Mindfulness-Oriented Recovery Enhancement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Montana
Opioid-use Disorder
The Effect of Buprenorphine Continuation for Patients With Opioid Use Disorder
There is limited guidance on the optimal management of buprenorphine perioperatively and both buprenorphine discontinuation and continuation are acceptable standards of care.
- Trial name
- NCT04981678
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MaineHealth
Pain, Postoperative
The Use of Cannabidiol (CBD) in Pain Reduction and Opioid Use After Shoulder Arthroscopy
This study is designed to evaluate the effects of administering CBD to control post-operative pain in patients undergoing shoulder arthroscopy.
- Trial name
- NCT04672252
- Testing
- CBD Oral Disintegrating Tablet (ODT)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Pain
Effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores
Opioids are effective analgesics, but cause side effects including sedation, respiratory depression, low blood pressure, nausea, and constipation.
- Trial name
- NCT02840240
- Testing
- Gabapentin enacarbil
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- The Cleveland Clinic
Heroin Dependence
Buprenorphine Stabilization and Induction Onto Vivitrol for Heroin-dependent Individuals
A short-term treatment with buprenorphine prior to initiating treatment with naltrexone may increase the proportion of heroin-dependent patients successfully inducted onto Vivitrol.
- Trial name
- NCT03711318
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Chronic Pain
Treatment, Pain, and Opioids
Background: Chronic pain and negative consequences of long-term opioid therapy are related public health concerns associated with significant functional impairment, high psychiatric comorbidity, and premature mortality…
- Trial name
- NCT05363176
- Testing
- Cognitive-Behavioral Therapy for Treatment Seeking, Pain treatment education
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Opioid-Related Disorders, Opiate Dependence
Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P05444)
The purpose of this study is to evaluate the acceptability and safety of switching to Suboxone® (buprenorphine plus naloxone) and the effect of the switch on medication dispensing.
- Conditions
- Opioid-Related Disorders, Opiate Dependence, Drug Abuse
- Trial name
- NCT00725608
- Testing
- buprenorphine/naloxone
- Where
- Austria
- Volunteers
- 339 people
- Sponsor
- Indivior Inc.
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Marijuana Use
Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana
The purpose of this study is to determine if the subjective effects of marijuana will be decreased by low-doses (< 25 mg) of naltrexone and increased by high-doses (> 50 mg) of naltrexone.
- Trial name
- NCT00403117
- Testing
- Naltrexone 12 Mg+ Active Marijuana (3.27% THC), Naltrexone 25 Mg + Active Marijuana (3.27% THC), Naltrexone 50 Mg+ Active Marijuana (3.27% THC)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Chronic Pain
A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine
Characterize the relative abuse liability of a short versus a long acting opioid in chronic pain patients.
- Trial name
- NCT00314340
- Testing
- Markers of Abuse Liability, Neuropsych Testing, and Cue Reactivity, ER Morphine, hydrocodone plus acetaminophen
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Sickle Cell Anemia Crisis
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.
- Trial name
- NCT03541980
- Testing
- Acetaminophen, Normal saline
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Newark Beth Israel Medical Center
Opiate Dependence
Counseling for Primary Care Office-based Buprenorphine
The major goal is to determine whether adding cognitive behavioral therapy to physician management will increase the efficacy of buprenorphine/naloxone treatment in an office-based primary care setting.
- Trial name
- NCT00595764
- Testing
- Manual-guided Physician Management (PM), Physician Management (PM) combined with on-site manual-guided Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Yale University
Sleep Apnea Syndromes
Sleep Disordered Breathing and Chronic Pain
The purpose of this study is to evaluate positive pressure in patients with chronic pain taking opioid medications who have sleep disordered breathing.
- Trial name
- NCT01457014
- Testing
- servo ventilation auto, Continuous positive airway pressure, servo ventilation manual
- Where
- 4 sites in United States
- Volunteers
- 88 people
- Sponsor
- Philips Respironics
Fusion of Spine, Lumbar Region
The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion
Simple explanation and rationale: Recovery after spine surgery is usually accompanied by severe pain which has traditionally been managed with opioids.
- Trial name
- NCT03104816
- Testing
- Acetaminophen IV Soln 10 MG/ML, Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Pain, Cancer
An Efficacy and Safety Study of Fentanyl (JNS020QD) in Participants With Cancer Pain
The purpose of this study is to evaluate the safety and efficacy of fentanyl one-day transdermal patch (patch containing a drug that is put on the skin so the drug will enter the body through the skin) in participants switched…
- Trial name
- NCT00641667
- Testing
- Fentanyl
- Where
- Japan
- Volunteers
- 66 people
- Sponsor
- Janssen Pharmaceutical K.K.
Post Operative Pain, Hyperalgesia
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery.
- Trial name
- NCT01594047
- Testing
- ketamine infusion, Methadone PCA
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
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