Clinical trials: Opioids
Pain, Postoperative, Opioid Use
Erector Spinae Plane Blocks for Adolescent Idiopathic Scoliosis
Pediatric spinal fusion (PSF) surgery is a painful procedure that can treat adolescent idiopathic scoliosis (AIS). One technique that can potentially reduce patients' pain levels and need for opioid medication is the…
- Conditions
- Pain, Postoperative, Opioid Use, Recruitment
- Trial name
- NCT04500613
- Testing
- Bilateral Erector Spinae Plane Block with bupivacaine and dexamethasone, No bilateral Erector Spinae Plane Block (no bupivacaine and no dexamethasone)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hospital for Special Surgery, New York
Substance Withdrawal Syndrome
Efficacy of Extended Release Tramadol for Treating Prescription Opioid Withdrawal
Prescription opioid addiction is a growing public health problem and more pharmacologic treatments are needed because current approved medications have had limited patient acceptance (naltrexone), limited availability…
- Trial name
- NCT00980044
- Testing
- Tramadol
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Michelle Lofwall
Cocaine Dependence
Cocaine Use Reduction With Buprenorphine
The aim of this study is to investigate the safety and effectiveness of buprenorphine in the presence of naltrexone for the treatment of cocaine dependence.
- Trial name
- CURB (NCT01402492)
- Testing
- Buprenorphine + Naltrexone
- Where
- 11 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of California, Los Angeles
Adherence, Depression
Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1
Patients with HIV, depression, and opioid-dependence are at high risk for poor health outcomes. This is a two-arm randomized controlled trial of cognitive-behavioral therapy for depression and HIV medication adherence in patients…
- Conditions
- Adherence, Depression, Heroin Dependence, Methadone
- Trial name
- NCT00218634
- Testing
- CBT-AD, ETAU
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Massachusetts General Hospital
Acute Pain
IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients
The goal of this randomized clinical trial is to compare the analgesic efficacy and side effect profile of IV acetaminophen as an analgesic adjunctive medication to IV hydromorphone for the treatment of acute pain experienced by…
- Trial name
- NCT03553498
- Testing
- IV acetaminophen, hydromorphone
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Albert Einstein College of Medicine
Opioid-use Disorder
An Open-Label Pilot Study of Sublocade as Treatment for Opiate Use Disorder
The proposed study is a 12-week, open-label pilot study of sublocade (extended-release burprenorphine, BXR) as treatment for opiate use disorder (OUD) testing positive for Highly Potent Synthetic Opioids (HPSO).
- Trial name
- NCT03861338
- Testing
- Sublocade
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- New York State Psychiatric Institute
Opioid Abuse, Prescription Drug Abuse (Not Dependent)
Validation of a Community Pharmacy-Based Prescription Drug Monitoring Program Risk Screening Tool
The goal of the study is to validate a Prescription Drug Monitoring Program-based opioid risk metric to discriminate between low, moderate, and high-risk opioid use disorder.
- Trial name
- PHARMSCREEN (NCT03936985)
- Where
- 2 sites in United States
- Volunteers
- 1,464 people, healthy volunteers welcome
- Sponsor
- University of Utah
Stigma, Social, Opioid Use
SMART Trial: Intrapersonal and Interpersonal Stigma Reduction
The goal of this project is to develop a multicomponent stigma reduction intervention to address intrapersonal (individual) stigma regarding Opioid Use Disorder (OUD).
- Conditions
- Stigma, Social, Opioid Use, Opioid-use Disorder, Substance Use Disorders
- Trial name
- NCT04693416
- Testing
- Intrapersonal Stigma Reduction, Interpersonal Stigma Reduction
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Tennessee
Chronic Pain
Trial of Chronic Pain Self-Management in Clinic or Community for Low-Income Hispanics
The purpose of this study is to conduct a parallel group, randomized trial of a chronic pain self-management program in clinic or community settings to educate and support low-income, Hispanic patients with chronic pain to adopt…
- Trial name
- NCT02906358
- Testing
- Community-based pain self-management, Clinic-based pain self-management
- Volunteers
- 111 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pain
Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring
This research is being done to compare two methods of giving fentanyl, a narcotic often given to patients following brain surgery and determine if one method has more side effects than the other.
- Trial name
- NCT01327677
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Johns Hopkins University
Hypoxia, Apnea
Use of Capnography in EGD and Colonoscopy With Moderate Sedation.
This study will provide capnography monitoring during routine upper endoscopy and colonoscopy with moderate sedation in order to see if it improves safety.
- Conditions
- Hypoxia, Apnea, Hypotension, Hypopnea
- Trial name
- NCT01994785
- Testing
- Capnographic Monitoring
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- The Cleveland Clinic
Opioid Use Disorder
Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making…
- Trial name
- NCT03958474
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joshua A. Lile, Ph.D.
Opioid-use Disorder, Mental Disorder
Start Treatment and Recovery for Opioid Use Disorder
The purpose of this study is 1) to evaluate whether emergency department-initiated medically assisted treatment with Buprenorphine/Naloxone in patients presenting with opioid use disorder will produce positive outcomes at 1 week…
- Conditions
- Opioid-use Disorder, Mental Disorder, Opioid Medication Assisted Treatment
- Trial name
- STAR (NCT04505540)
- Testing
- Bridge Clinic
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Vermont
Buprenorphine, Naloxone
Observational Study of Misuse of High Dose Buprenorphine (Subutex® or Generic) in Opiate-Addicted Patients in France (Study P05186AM1)(COMPLETED)
The purpose of this study is to assess the risks of abuse, misuse and adverse events related to high dose buprenorphine. Approximately 1250 patients taking Subutex (Schering-Plough) or its Buprenorphine High Dose (BHD) generic…
- Conditions
- Buprenorphine, Naloxone, Opiate-related Disorders, Opiate Dependence
- Trial name
- OPUS R (NCT00723697)
- Testing
- buprenorphine
- Volunteers
- 1,307 people
- Sponsor
- Indivior Inc.
Respiratory Depression
OSA Screen Negative With Spinal Duramorph
Non emergent scheduled cesarean sections will be consented to participate in this study of patients who have screened negative for obstructive sleep apnea and who are also BMI>/= 35 to have capnography monitoring postoperatively.
- Trial name
- NCT03151226
- Testing
- Capnography monitoring
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Analgesia, Obstetrical, Obstetric Surgical Procedures
Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery
Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing.
- Trial name
- NCT02789410
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Hiv, Opioid-use Disorder
Integrating Addiction Treatment and HIV Services Into Primary Care Clinics in Ukraine
A randomized controlled trial to: 1. To compare both primary (composite quality health indicator (QHI) scores) and secondary (individual HIV/methadone maintenance treatment (MMT)/TB/primary care QHI scores, quality of life, and…
- Trial name
- IMPACT (NCT04927091)
- Testing
- Integration of HIV and PWID services
- Where
- Ukraine
- Volunteers
- 1,590 people
- Sponsor
- Yale University
Substance-Related Disorders
Behavioral Insights to Encourage Judicious Prescribing of Opioids
In collaboration with the San Diego Medical Examiner's Office and the State of California's controlled Substance Utilization Review and Evaluation System (CURES), the investigators propose to review opioid poisonings over the…
- Trial name
- NCT02790476
- Testing
- Letters
- Where
- United States
- Volunteers
- 851 people
- Sponsor
- University of Southern California
Laparoscopic Sleeve Gastrectomy, Subcostal Transversus Abdominis Plane Block
Unilateral TAP Block for Laparoscopic Gastric Sleeve Surgery
The study team will be assessing if the unilateral subcostal transversus abdominis plane (TAP) block can decrease pain and improve outcomes following laparoscopic sleeve gastrectomy surgeries.
- Trial name
- NCT03856788
- Testing
- Saline, Bupivacaine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid-Related Disorders
Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users
To determine the relative abuse potential of VYCAVERT (hydrocodone bitartrate and acetaminophen) compared to GENERIC H/A (hydrocodone bitartrate and acetaminophen) when crushed and administered intranasally to non dependent…
- Trial name
- NCT01759446
- Testing
- Generic H/A taken first, Vycavert taken first, Generic H/A plus i taken first
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
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