Clinical trials: Optic Disk
Persistent Epithelial Defect
A Study to Investigate the Safety and Clinical Effect of Nexagon® to Treat Persistent Epithelial Defects
The purpose of this study is to evaluate the efficacy and safety of Nexagon® in subjects with Persistent Epithelial Defects (PED) originally caused by chemical burns.
- Trial name
- NCT00821561
- Testing
- Nexagon®, Nexagon® vehicle
- Volunteers
- 90 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Glaucoma
Spectralis OCT Repeatability and Reproducibility Study
This single-center, prospective, interventional clinical study is conducted to evaluate the repeatability and reproducibility of structural parameters of the optic nerve head, the peripapillary retinal nerve fiber layer, and the…
- Trial name
- S-2013-1 (NCT02209077)
- Testing
- OCT performed to collect data from the back of the eye
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Normal Healthy Subjects With No Known Ocular Diseases, Glaucomatous Eyes
Clinical Study of the Optic Disc Parameters
Assess the repeatability and agreement of the Optic Disc Parameters, Retinal Nerve Fiber Layer (RNFL) Thickness, and Full Retinal Thickness between the Maestro and iVue OCT devices
- Conditions
- Normal Healthy Subjects With No Known Ocular Diseases, Glaucomatous Eyes, Eyes With Retinal Diseases
- Trial name
- NCT02277119
- Testing
- Maestro, iVue
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Healthy
Optical Coherence Tomography (OCT) Normative Data Collection Study
This study is being initiated to create a normal database including measures of optic nerve head (ONH), peripapillary retinal nerve fiber layer (RNFL), and macula using the Heidelberg Spectralis OCT device.
- Trial name
- S-2013-3 (NCT02014688)
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Corneal re-Epithelialization
A Study to Assess the Safety, Tolerability and Effect of Nexagon™ Applied to the Eye After PRK Laser Eye Surgery for Nearsightedness
Phase 1 randomized, prospective, double-masked, vehicle-controlled, dose-escalation study to evaluate the safety, tolerability and clinical effect of Nexagon™ in subjects following bilateral PRK for the correction of mild to…
- Trial name
- NCT00654550
- Testing
- Nexagon™ or Nexagon™ vehicle
- Where
- New Zealand
- Volunteers
- 24 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Myopia, Astigmatism
Use of a Disk of Amniotic Membrane (Visio-AMTRIX) in Postoperative Care After PKR
The purpose of this open controlled multicenter trial is to assess the impact of use of an amniotic membrane on post PKR recovery.
- Conditions
- Myopia, Astigmatism, Hypermetropia
- Trial name
- NCT05247658
- Testing
- Therapeutic lens alone, Therapeutic lens + amniotic membrane (Visio-AMTRIX)
- Where
- 3 sites in France
- Volunteers
- 9 people
- Sponsor
- TBF Genie Tissulaire
Glaucoma
Comparison of Optic Nerve Head and Retinal Nerve Fiber Layer Parameters Derived From Two Different Methods of Scan Alignment
This prospective, monocentric, non-invasive clinical study is designed to measure normal structural parameters of the optic nerve head, the peripapillary retinal nerve fiber layer, and the macula using the Heidelberg Spectralis…
- Trial name
- NCT02666144
- Testing
- Spectralis OCT
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Macula Edema, Radiation Retinopathy
Phase I Study of Episcleral Celecoxib for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
This phase I trial will assess primarily the safety and secondarily the anti-inflammatory and anti-neovascular effect of Episcleral Celecoxib in patients suffering from macular edema and other inflammatory disorders of the…
- Conditions
- Macula Edema, Radiation Retinopathy, Branch Retinal Vein Occlusion, Epiretinal Membrane
- Trial name
- NCT04120636
- Testing
- Episcleral Celecoxib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Targeted Therapy Technologies, LLC
Ocular Physiology
Data Collection Study of the Nidek Optical Coherence Tomography RS-3000 for 3D Measurements of the Eye
The purpose of this clinical study is to collect and evaluate the data from eye scans using an investigational three-dimensional eye imaging photography device called the Nidek Optical Coherence Tomography (OCT) RS-3000.
- Trial name
- NCT01663688
- Where
- 3 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Healthy
Optical Coherence Tomography (OCT) Normative Data Collection Study (S-2013-2)
This study is being initiated to create a normal database including measures of optic nerve head (ONH), peripapillary retinal nerve fiber layer (RNFL), and macula using the Heidelberg Spectralis OCT device.
- Trial name
- S-2013-2 (NCT02089711)
- Where
- Japan
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Retina Disease, Glaucoma
Optic Disc Photograph Collection Study
The objective of this study is to collect stereo-optic disc photographs for potential future analysis.
- Conditions
- Retina Disease, Glaucoma, Normal
- Trial name
- NCT05532410
- Testing
- Fundus Camera
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Glaucoma, Retinal Disease
Nidek RS3000 Comparative Study
The primary objective of this clinical study is to compare the Nidek RS-3000 Optical Coherence Tomography (OCT) device to the Optovue RTVue OCT.
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT01384487
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Glaucoma, Retinal Disease
OCT Agreement and Crossed Precision Study
The purpose of this study is to asses the agreement of the RS-3000 Lite and RS-3000 Advance to the RS-3000, assess the crossed precision of each study device and to assess the transference of a reference database from the RS-3000…
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT02050880
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Macular Edema, Radiation Retinopathy
Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
This phase I trial will assess primarily the safety and secondarily anti-inflammatory effect of Episcleral Dexamethasone in patients suffering from macular edema and other disorders of the retina, choroid and vitreous.
- Conditions
- Macular Edema, Radiation Retinopathy, Branch Retinal Vein Occlusion, Epiretinal Membrane
- Trial name
- NCT04120311
- Testing
- Episcleral Dexamethasone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Targeted Therapy Technologies, LLC
Dry Eye Disease (DED)
Evaluate the Efficacy and Safety of Amnion Membrane Disc Allograft vs Standard of Care in Participants With Dry Eye Disease
To evaluate the efficacy of Lyophilized Human Amnion Membrane Disc in reducing corneal epithelial damage as measured by the Lexitas Modified National Eye Institute (NEI) Grading Scale for Corneal Fluorescein Staining.
- Trial name
- BLINK (NCT07529899)
- Testing
- Standard of Care (SOC), Lyophilized Amnion Membrane Disc Allograft
- Sponsor
- Cellution Biologics