Clinical trials: Optic Nerve Diseases
Emergence Delirium
Intranasal Dexmedetomidine Versus Intranasal Midazolam for Emergence Delirium Prevention
This study is a double-blind clinical trial, in pediatric patients aged 1-12 years with physical status ASA (American Society of Anesthesiology) 1 and 2 who underwent eye surgery under general anesthesia using Sevoflurane…
- Trial name
- NCT04263844
- Testing
- Intranasal dexmedetomidine, Intranasal Midazolam
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Macular Degeneration, Low Vision
The Effect of Duration Between Sessions on Microperimetric Biofeedback Training in Patients With Maculopathies
Patients who develop macular diseases have several clinical complications,such as central vision loss, the central scotoma of the visual field, the decrease of reading speed and fixation stability.
- Conditions
- Macular Degeneration, Low Vision, Stargardt Disease
- Trial name
- NCT05904444
- Testing
- microperimetric biofeedback training
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Aier Eye Hospital, Guangzhou
Branch Retinal Vein Occlusion
Assessment Of Peri-papillary Retinal Nerve Fiber Layer Thickness In Patients With Unilateral Branch Retinal Vein Occlusion
Several studies have indicated a relation between the development of RVO and elevated intraocular pressure (IOP) and glaucoma [9].
- Trial name
- NCT06146309
- Testing
- aflibercept (2mg/0.05ml)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill tumor cells.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Liver Cancer
- Trial name
- NCT00007813
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Refractive Errors
Clinical Evaluation of Acuity 200 (Fluoroxyfocon A) RGP Contact Lens
The objective of this clinical investigation is to collect valid scientific safety and effectiveness data on the Acuity 200 (fluoroxyfocon A) Rigid Gas Permeable Contact Lens, manufactured from a newly developed rigid gas…
- Trial name
- Acuity 200 (NCT03971227)
- Testing
- Acuity 200 (Fluoroxyfocon A) contact lens, Acuity 100 (Hexafocon A) contact lens
- Where
- 3 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Acuity Polymers, Inc.
Visual Impairments
Effects of Reformer Pilates and Vestibular Exercise Programs on Balance and Gait in Children With Visual Impairment
This study looks at whether Reformer Pilates can help children and adolescents with visual impairment improve their balance, walking patterns, and muscle strength. Participants are between 10 and 17 years old.
- Trial name
- NCT07789691
- Testing
- Equipment-Based Pilates Exercise (Reformer), Vestibular Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Amblyopia
Standard Amblyopia Therapy in Adult Amblyopes
Amblyopia is characterized by a reduction in visual acuity, contrast sensitivity, and binocular visual functions. The two main causes of amblyopia are anisometropia and strabismus which alter the synaptic connections between…
- Trial name
- NCT03341780
- Testing
- amblyopia therapy
- Volunteers
- 9 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Strabismus
Bilateral and Unilateral Horizontal Strabismus Surgery
This study was done in alternating strabismus patients to compare symmetrical muscle surgery and asymmetrical one as regard efficacy and lateral incomitance after surgery
- Trial name
- NCT04199286
- Testing
- symmetrical and asymmetrical horizontal strabismus surgery
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
This is a sub-study of Study RM-493-040 (NCT05774756). The goal of this sub-study is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with…
- Conditions
- Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form, Septo-Optic Dysplasia, Optic Nerve Hypoplasia
- Trial name
- NCT06760546
- Testing
- Setmelanotide
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Neurofibromatosis Type 1, Recurrent Childhood Brain Stem Glioma
Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors
This phase I trial studies the side effects and best dose of pomalidomide in treating younger patients with tumors of the brain or spine (central nervous system) that have come back or are continuing to grow.
- Conditions
- Neurofibromatosis Type 1, Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Visual Pathway Glioma, Recurrent Primary Central Nervous System Neoplasm
- Trial name
- NCT02415153
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Pomalidomide
- Where
- 12 sites in United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Horner's Syndrome
Horner's SD After Thoracic Epidural Block
This study prospectively evaluates the incidence of Horner's syndrome after thoracic epidural anesthesia following continuous thoracic epidural analgesia for mastectomy.
- Trial name
- NCT02130739
- Testing
- thoracic epidural anesthesia, mastectomy, Ropivacaine
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Soonchunhyang University Hospital
Choroidal Neovascularization
Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study
Efficacy of monthly intravitreal anti-vascular endothelial growth factor (VEGF) associated to systemic immunosuppression in patients with Vogt-Koyanagi-Harada Disease and choroidal neovascularization. Minimum follow-up 12 months.
- Trial name
- NCT02015351
- Testing
- bevacizumab
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- University of Sao Paulo
Optic Neuritis, Treatment
Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis Trial
A double-blind prospective randomized clinical trial of treatment for optic neuritis comparing visual outcome of patients treated by standard therapy (intravenous methylprednisolone) + placebo injection and standard therapy +…
- Conditions
- Optic Neuritis, Treatment, Methylprednisolone
- Trial name
- NCT04942002
- Testing
- Methylprednisolone Acetate 40 MG/ML [Depo-Medrol]
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asociación para Evitar la Ceguera en México
Autosomal Dominant Optic Atrophy, Optic Atrophy, Autosomal Dominant
Natural History of Autosomal Dominant Optic Atrophy (ADOA), Caused by OPA1 Mutation
The purpose of this study is to characterize the disease progression of confirmed OPA1 mutation-associated autosomal dominant optic atrophy (ADOA) by evaluating the changes in ocular structural and functional outcomes.
- Conditions
- Autosomal Dominant Optic Atrophy, Optic Atrophy, Autosomal Dominant, Optic Atrophies, Hereditary, Kjer Optic Atrophy
- Trial name
- NCT06140329
- Where
- 7 sites in United States, Australia and 4 more
- Volunteers
- 1 people
- Sponsor
- PYC Therapeutics
Intracranial Atherosclerosis, Optical Coherence Tomography
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).
- Conditions
- Intracranial Atherosclerosis, Optical Coherence Tomography, Plaque, Atherosclerotic, Artery Stenosis
- Trial name
- OCT-ICAS (NCT05550077)
- Testing
- Optical Coherence Tomography, Percutaneous transluminal angioplasty and stenting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- jiaoliqun
Acute Coronary Syndromes (ACS), Sleep Quality
Eye-Ear Sleep Band for Sleep Quality in Coronary Care Unit
Sleep disturbances are common in patients admitted to the coronary care unit (CCU), where continuous light, noise, and monitoring equipment disrupt normal sleep.
- Conditions
- Acute Coronary Syndromes (ACS), Sleep Quality, Sleep Deprivation
- Trial name
- EESQ-CCU (NCT07490743)
- Testing
- Eye-Ear Sleep Band, Standard CCU Care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Koç University
Agitation
Different Premedication in Pediatric Patients
The investigators studied the effects of intranasal dexmedetomidine compared with oral midazolam with different doses for premedication in children.
- Trial name
- NCT04266340
- Testing
- dexmedetomidine, midazolam, Saline
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Parkinson Disease, Healthy Adult Participants
Brain Dopamine Biomarker
This study is being conducted at the Morsani College of Medicine to determine whether signals recorded from the eyes and brain can be used as a noninvasive way to monitor dopamine function.
- Trial name
- B3-4D (NCT07748715)
- Testing
- Levadopa/Carbidopa eyedrops, Levodopa/Carbidopa (Sinemet)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Retinitis Pigmentosa, Usher Syndrome Type 2
Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)
The purpose of this study is to evaluate the efficacy safety and tolerability of QR-421a administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene with…
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Deaf Blind, Retinal Disease
- Trial name
- NCT05176717
- Testing
- QR-421a
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 5 people
- Sponsor
- Laboratoires Thea
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