Clinical trials: Optic Nerve Diseases
Myopia, Amblyopia
Access to EyeGlasses for School-aged Children
Uncorrected refractive error is a leading cause of visual impairment in children and can impact vision, quality of life, and academic performance.
- Conditions
- Myopia, Amblyopia, Hyperopia, Refractive Errors
- Trial name
- ATEG (NCT05588362)
- Testing
- Fitz Frames 3-D Printed Glasses
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Visual Impairment
Digital Twin Smart Educational Platform for Visually Impaired Navigation Training
This study evaluates a novel digital twin smart educational platform designed to train visually impaired individuals on safe navigation in Saudi urban environments.
- Trial name
- NCT07641127
- Testing
- Adaptive Multi-modal Digital Twin Navigation Training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- King Salman Center for Disability Research
Systemic Lupus Erythematosus, Sjögren's Disease
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Sjögren's Disease, Rheumatoid Arthritis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07873931
- Testing
- BMS-986553
- Where
- 23 sites in United States, Belgium and 4 more
- Volunteers
- 60 people
- Sponsor
- Bristol-Myers Squibb
Diabetes Mellitus, Diabetic Retinopathy
Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy
The object of this study is to investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Nerve Injury
- Trial name
- NCT03970161
- Testing
- routine ophthalmic examination
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Optic Radiation Neuropathy Following Radiotherapy Procedure
Optical Coherence Tomography Angiography Characteristics of Radiation Optic Neuropathy
Aim: To develop a suitable radiation optic neuropathy (RON) diagnostic model based on optical coherence tomography angiography (OCTA) and to reveal the correlation between endocrine and OCTA indexes in nasopharyngeal carcinoma…
- Trial name
- NCT05895851
- Testing
- head and neck radiation
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Metamorphopsia
Comparison of Quantitative Metamorphopsia- Measurements in Patients With mCNV
The myopic CNV (mCNV) is a blood vessel neoplasm starting from the choroid, based on pathological myopia (severe myopia). Choroidal neovascularization secondary to pathological myopia is the most common cause of severe visual…
- Trial name
- NCT04112524
- Testing
- App
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- PD Dr. med. Katja Hatz
Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness)
Effect of Presbyopia Correction on Livelihood and Repayment Among Solar Customers in Western Region, Kenya
With age, people lose the ability to see things that are near them clearly. This is known as presbyopia. Although this is a normal ageing process, it can be corrected with near vision eyeglasses - colloquially known as reading…
- Conditions
- Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness), Repayment Behaviour, Livelihoods
- Trial name
- NCT06774183
- Testing
- Near vision glasses for presbyopia correction
- Volunteers
- 1,085 people
- Sponsor
- Dot Glasses Kenya
Inherited Mitochondrial Disease, Including Leigh Syndrome
Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease
To evaluate safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) administered at a target maintenance dose of 1.3 g/m²/day in two divided doses, every 12 hours, for up to 6 months in…
- Trial name
- MITO-001 (NCT02023866)
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Amgen
ALS, Autism Spectrum Disorder
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
This is an observational study of medical marijuana manufactured and dispensed by Ilera and given as standard treatment for a variety of approved serious medical conditions as defined by individual state law.
- Conditions
- ALS, Autism Spectrum Disorder, Cancer, Spasticity, Muscle
- Trial name
- Ilera (NCT03886753)
- Testing
- Registry, PK microsampling of blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Wolfram Syndrome 1, Optic Atrophies, Hereditary
Does Recessive Optic Atrophy Due to WFS1 Exist?
All patients with Wolfram syndrome and recessive optic atrophy due to a mutation of the WFS1 from a single Center were included in a retrospective study.
- Trial name
- NCT07336966
- Testing
- analyse study
- Volunteers
- 45 people
- Sponsor
- Hôpital Necker-Enfants Malades
Optic Disc Edema, Endothelial Dysfunction
B-Complex: A Nutraceutical SANS Countermeasure
In this project, the investigators propose to test effectiveness of a daily nutraceutical supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts.
- Trial name
- NCT05366933
- Testing
- Vitamin B-Complex Supplement
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Homonymous Hemianopia
Clinical Trial of Multi-Periscopic Prism Glasses for Hemianopia
This clinical trial will evaluate the efficacy of two types of high-power prism glasses that provide field of view expansion for patients with homonymous hemianopia (the complete loss of half the field of vision on the same side…
- Trial name
- NCT04827147
- Testing
- Multi-Periscopic Prism (MPP) glasses, Fresnel Peripheral Prism (FPP) glasses
- Where
- 8 sites in United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Loss of Visual Contrast Sensitivity, Near Vision
Visual Performance Following Implantation of Presbyopia Correcting IOLs
The purpose of the current study was to compare the visual performance after bilateral implantation of the Panoptix IOL , or the AT LISA IOL or Tecnis Symfony IOL .
- Conditions
- Loss of Visual Contrast Sensitivity, Near Vision, Visual Impairment
- Trial name
- NCT04907955
- Testing
- phacoemulsification with implantation of presbyopia correcting IOL
- Where
- Kuwait
- Volunteers
- 50 people
- Sponsor
- Dar Al Shifa Hospital
Eye Injuries
An Exploratory Study of Visual Function Rehabilitation in Patients With Ocular Trauma
Ocular trauma is one of the leading causes of blindness worldwide, often resulting in severe visual impairment or even loss of vision after injury.
- Trial name
- NCT06174415
- Testing
- Perceptual Learning
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Vision Disorders
Unmet Needs, Barriers and Facilitators to Vision Services for Children and Adolescents With Special Vision
Children and adolescents with special needs, compared to those with general development, have a much higher incidence of visual impairments (10.5% vs. 0.16%).
- Trial name
- NCT05921240
- Testing
- observational study, no intervention
- Where
- Taiwan
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Migraine Disorders, Photophobia
Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Patients With Migraine
Approximately 9% of men and 18% of women suffer from migraine headaches. Almost all migraine sufferers report light sensitivity during a headache.
- Trial name
- NCT01828684
- Testing
- Therapeutic Lens Coating
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Bradley Katz
Spinal Cord Injury Cervical, Tetraplegia
Epidural Stimulation for Upper Extremity Function
Restoring upper extremity function in patients with cervical spinal cord injury is extremely important for patients' independence and quality of life.
- Trial name
- NCT06437548
- Testing
- Percutaneous spinal cord stimulation
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Enucleated; Eye, Evisceration; Operation Wound
Retrobulbar Block Versus Ketamine Infusion for Post-enucleation Analgesia
This study compares the efficacy and safety of two techniques, retrobulbar block versus intra-operative ketamine infusion, for control of post-operative pain occurring in patients undergoing ocular enucleation or evisceration…
- Conditions
- Enucleated; Eye, Evisceration; Operation Wound, Pain, Postoperative
- Trial name
- NCT03507426
- Testing
- Retrobulbar block, Ketamine
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Nazmy Edward Seif
Amblyopia
An Active Approach to Treat Amblyopia: Video Game Play
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT01223716
- Testing
- Perceptual learning, Video Game, Crossover (Occlusion therapy + Video Game)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.