Clinical trials: Optic Nerve Diseases
Retinitis Pigmentosa
Prospective Natural History Study of Retinitis Pigmentosa
This is natural history study of rods and cones degenerations in patients with Retinitis Pigmentosa (RP) caused by pathogenic mutations in RHO, PDE6a or PDE6b gene mutations.
- Trial name
- PHENOROD2 (NCT04285398)
- Testing
- Ophthalmic examinations, Mobility Test
- Where
- 2 sites in United States, France
- Volunteers
- 82 people
- Sponsor
- SparingVision
Focus: Surgical Smoke During Laparoscopic Surgery
Assessment of a New Surgical Smoke Clearing Technology in Laparoscopic Cholecystectomy
The study will examine the safety and performance of a new surgical smoke clearance system designed for use during laparoscopic surgery.
- Trial name
- Innervision (NCT01534832)
- Testing
- Innervision Surgical Smoke Removal System
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Asalus Medical Instruments Limited
Multiple Sclerosis, Optic Neuritis
Longitudinal Optic Neuritis Study (LONS)
To assess the beneficial and adverse effects of corticosteroid treatment for optic neuritis. To determine the natural history of vision in patients who suffer optic neuritis.
- Trial name
- NCT00000147
- Testing
- Methylprednisolone, Prednisone
- Where
- 15 sites in United States
- Sponsor
- National Eye Institute (NEI)
Neuromyelitis Optica Spectrum Disorder
A Study of MIL62 in Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD)
This study will evaluate the safety and efficacy of MIL62 in patients with Neuromyelitis Optica Spectrum Disorder.
- Trial name
- NCT05314010
- Testing
- MIL62
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Mabworks Biotech Co., Ltd.
Acute Coronary Syndromes (ACS), Sleep Quality
Eye-Ear Sleep Band for Sleep Quality in Coronary Care Unit
Sleep disturbances are common in patients admitted to the coronary care unit (CCU), where continuous light, noise, and monitoring equipment disrupt normal sleep.
- Conditions
- Acute Coronary Syndromes (ACS), Sleep Quality, Sleep Deprivation
- Trial name
- EESQ-CCU (NCT07490743)
- Testing
- Eye-Ear Sleep Band, Standard CCU Care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Koç University
Glaucoma
Optic Nerve Head Shape as a Predictor of the Formation of Acquired Pits of the Optic Nerve (APONs)
Acquired pits of the optic nerve (APONs) are an area of focal loss of neural tissue associated with a discrete area of depression/excavation within the optic cup at the level of the lamina cribrosa.
- Trial name
- NCT04610008
- Testing
- No intervention. Purely observation
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- Cardiff and Vale University Health Board
Eye Injuries
Anterior Segment Spectral-domain Optical Coherence Tomography in Patients With Closed Globe Injury
This study use anterior segment spectral-domain optical coherence tomography (SD-OCT) to exam patients with closed globe injury, and compared with slit lamp examination.
- Trial name
- NCT02638025
- Testing
- OCT
- Volunteers
- 16 people
- Sponsor
- Huizhou Municipal Central Hospital
Healthy Volunteers, Relative Afferent Pupil Defect
The PUPIL Study - Automated, Quantitative Pupil Assessment Using Binocular OCT
In current, clinical ophthalmology, a range of specialised testing allows comprehensive evaluation of ocular health. These tests have typically evolved over many years to ensure their clinical validity.
- Conditions
- Healthy Volunteers, Relative Afferent Pupil Defect, Pupil Anomaly
- Trial name
- NCT03081468
- Testing
- Binocular OCT prototype, Konan RAPDx
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Visual Acuity, Refractive Errors
Pre-symptomatic Screening of Visual Acuity in Pre-school Students
The present research process is a prospective, non-interventional clinical study that will be conducted -under the auspices of the Democritus University of Thrace (DUTH)- in the pre-school students of the city of Alexandroupolis…
- Conditions
- Visual Acuity, Refractive Errors, Low Vision, Vision Disorders
- Trial name
- NCT05835193
- Testing
- Diagnostic Test: Distance Visual Acuity Examination
- Where
- Greece
- Volunteers
- 1,098 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Renal Insufficiency, Chronic, Glaucoma
Intraocular Pressure and Hemodialysis Midwestern Brazil
Objective: To evaluate the variation in intraocular pressure in patients with chronic kidney disease, according to the time interval between hemodialysis sessions and to the influence of weight and blood pressure on intraocular…
- Trial name
- EHPIOBRAZIL (NCT02405884)
- Testing
- Kowa HA-2 Perkins applanation tonometer.
- Volunteers
- 39 people
- Sponsor
- VER Excelência em Oftalmologia
Intracranial Pressure Increase, Seizures
Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
A total of 88 postictal children with generalized or focal seizures were included in the study. The ONSD and ONSD/ETD ratio was measured independently by a pediatric neurologist and pediatric emergency expert, three times in both…
- Conditions
- Intracranial Pressure Increase, Seizures, Children, Only
- Trial name
- ONSD (NCT06451289)
- Testing
- Head computered tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Parkinson Disease, Multiple System Atrophy
Research of Biomarkers in Parkinson Disease
The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Huntington Disease
- Trial name
- Genepark (NCT00465790)
- Where
- 5 sites in Croatia, France and 2 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Optic Neuropathy
Treatment of Optic Neuropathies Using Autologous Bone Marrow-Derived Stem Cells
A single arm, single center trial to assess the safety and efficacy of restoring function in damaged optic nerves using autologous purified populations of bone-marrow derived stem cells (BM-SCs) through a 24 month follow up…
- Trial name
- NCT02638714
- Testing
- Stem Cells
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- Stem Cells Arabia
Ischemic Optic Neuropathy
Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup)
To follow all patients enrolled in the original Ischemic Optic Neuropathy Decompression Trial (IONDT) to determine (1) the incidence of non-arteritic ischemic optic neuropathy (NAION) in the second eye, (2) changes in visual…
- Trial name
- NCT00000126
- Testing
- Surgery
- Where
- 24 sites in United States
- Sponsor
- National Eye Institute (NEI)
GNA11 Mutation-positive Metastatic Melanoma, GNAQ Mutation-positive Metastatic Melanoma
Efficacy and Safety Study of GSK1120212, a MEK Inhibitor, in Subjects With Uveal Melanoma
The purpose of this study is to determine whether GSK1120212, a MEK inhibitor, is an effective and safe treatment for cancer subjects with metastatic uveal melanoma and mutation-positive GNAQ or GNA11 metastatic melanoma.
- Conditions
- GNA11 Mutation-positive Metastatic Melanoma, GNAQ Mutation-positive Metastatic Melanoma, Cancer, Metastatic Uveal Melanoma
- Trial name
- NCT01328106
- Testing
- GSK1120212
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes, Diabetes Insipidus
Tracking Neurodegeneration in Early Wolfram Syndrome
The goal of this study is to determine the pattern of early neurodegenerative changes in WFS (Wolfram Syndrome). The investigator will perform cross-sectional and longitudinal assessments of youth with WFS, targeting sensitive…
- Conditions
- Type 1 Diabetes, Diabetes Insipidus, Diabetes Mellitus, Wolfram Syndrome
- Trial name
- TRACK (NCT02455414)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Adult Patients Developing Optic or Peripheral Neuropathy, While Receiving Tedizolid Therapy Between July 2019 and December 2024
Tedizolid Neuropathies
Tedizolid is a new oxazolidinone, related to linezolid. It has obtained marketing authorization for the treatment of skin and soft tissue infections.
- Trial name
- NCT07143240
- Testing
- Determine patient demographic and clinical characteristics at baseline
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Amblyopia, Vision; Low, One Eye (Other Eye Normal)
Next Generation Home Vision Assessment
Comparison of live remote paediatric digital vision testing outcomes versus face to face appointments in orthoptic clinic
- Conditions
- Amblyopia, Vision; Low, One Eye (Other Eye Normal), Pediatric Disorder
- Trial name
- NGHVA (NCT06428435)
- Testing
- Vision Test
- Where
- 4 sites in United Kingdom
- Volunteers
- 206 people
- Sponsor
- NHS Forth Valley
Choroid Disease, Carotid Stenosis
Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies, even when no ocular disease is identified.
- Conditions
- Choroid Disease, Carotid Stenosis, Carotid Atherosclerosis, Retinal Disease
- Trial name
- NCT05623293
- Testing
- eye - Optcial coherence tomography
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Universidade do Porto
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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