Clinical trials: Optic Nerve Diseases
Vertigo, Unsteadiness
Accuracy of a Diagnostic Algorithm for the Differential Diagnosis of Vertigo in the ED: the STANDING.
This study evaluate the diagnostic accuracy of a simplified clinical algorithm (STANDING) for the differential diagnosis of acute vertigo in the emergency department.
- Trial name
- STANDING (NCT02782962)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Chronic Pain, Depression Disorders
Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study
What is the purpose of this study? The use of medicinal cannabis has grown significantly in Brazil. However, because many patients use these products through "compassionate use" (when traditional treatments haven't worked), there…
- Conditions
- Chronic Pain, Depression Disorders, Anxiety Disorders, Quality of Life
- Trial name
- CANAREAL (NCT07362407)
- Testing
- Participants are followed while using cannabis-based products (such as CBD or THC oils, extracts, or isolates) as prescribed by their own physicians for therapeutic purposes.
- Where
- Brazil
- Volunteers
- 384 people
- Sponsor
- Santa Catarina Federal University
Cornea; Sense Loss
Investigation in Corneal Sensation
The aim is to find out more about how corneal sensory fibres react to different types of stimuli (liquid / tactile / nylon thread) and how this can be consciously perceived by the individual.
- Trial name
- NCT04045509
- Testing
- Liquid Jet Esthesiometer Prototype, Tactile Esthesiometer Prototype, Cochet Bonnet esthesiometer
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Brain Concussion
Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development
The purpose of this study is to prospectively collect a comprehensive, multi-modality set of diagnostics on patients who have had a concussion, repeating some of these tests serially over time, so that the investigators may then…
- Trial name
- NCT02519998
- Testing
- Concussion
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Neuromyelitis Optica (NMO), Neuromyelitis Optica Spectrum Disorders (NMOSD)
Slow vs. Rapid Glucocorticoids Tapering With Inebilizumab in NMOSD
Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system autoimmune condition mainly involving the spinal cord, optic nerves, and area postrema.
- Trial name
- STARGlu-NMO (NCT07132398)
- Testing
- Slow-tapering glucocorticoids + Inebilizumab, Rapid-tapering glucocorticoids + Inebilizumab
- Volunteers
- 170 people
- Sponsor
- Tianjin Medical University General Hospital
Visual Impairment
Telerehabilitation for Visually Impaired
the purpose of the study is to evaluate the software usability and patient's adherence from five vision rehabilitation centres. In addition, the effect and benefits of a customizable telerehabilitation program were tested.
- Trial name
- NCT05772793
- Testing
- Telerehabilitation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Amore Filippo
Intraocular Melanoma
Vaccine Therapy in Treating Patients With Melanoma of the Eye
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells and decrease the recurrence of melanoma of the eye.
- Trial name
- NCT00036816
- Testing
- MART-1 antigen, NA17-A antigen, gp100 antigen
- Where
- 2 sites in Belgium, Denmark
- Volunteers
- 13 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Amyotrophic Lateral Sclerosis
Brain-Computer Interface Communication Device for People With ALS
This study compares a wearable brain-computer interface (BCI) communication device with the eye-tracking communication devices that people with ALS already use.
- Trial name
- NCT07871071
- Testing
- Cognixion ONE AR-BCI configuration, Cognixion ONE screen-based BCI configuration, Existing eye-gaze speech generating device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cognixion
Binocular Vision Dysfunction, Vertical Heterophoria
Utility of a Survey Instrument to Predict Benefit From a Novel Treatment for Vertical Heterophoria
Patients with acute exacerbation of chronic headache disorder present frequently to the Emergency Department (ED) for pain management.
- Trial name
- VH (NCT01632787)
- Testing
- Questionnaires and Optometrist Prism Challenge/Treatment
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- Vision Specialists of Birmingham
Progressive Supranuclear Palsy(PSP)
The Progressive Supranuclear Palsy Clinical Trial Platform
The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) is a multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of PSP.
- Trial name
- PTP (NCT07173803)
- Testing
- AADvac1, LM11A-31
- Where
- 18 sites in United States
- Volunteers
- 440 people
- Sponsor
- Adam Boxer
Sleep Quality, Older Adults (65 Years and Older)
Effect of Health Promotion Model-Based Oculomotor Exercise Program on Sleep Quality in Older Adults
The goal of this clinical trial is to investigate the effect of a Health Promotion Model-based oculomotor exercise program on sleep quality among older adults living in a nursing home.
- Trial name
- NCT07261124
- Testing
- Oculomotor Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies
Single Ascending Dose Study in Participants With LCA10
The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of EDIT-101 administered via subretinal injection in participants with LCA10 caused by a homozygous or compound…
- Conditions
- Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies, Eye Diseases, Hereditary, Retinal Disease
- Trial name
- NCT03872479
- Testing
- EDIT-101
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Editas Medicine, Inc.
Pupil Constriction
Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia
Randomized contralateral eye study to evaluate the effect of one-time dosing of NV701 versus commercially available 1.25% pilocarpine solution on pupil size.
- Trial name
- NCT06783686
- Testing
- NV701, Pilocarpine 1.25% Eye drop
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Novus Vision LLC
PSP - Progressive Supranuclear Palsy
The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen A: AADvac1
The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) is a multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of PSP.
- Trial name
- NCT07217665
- Testing
- AADvac1
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Adam Boxer
Optic Neuropathy
STReetlab Assessment Tool of Activities Daily Living in Glaucoma Patient
The impact of glaucomatous optic neuropathy on the daily life of patients is poorly characterized and does not benefit from standardized tests.
- Trial name
- STRATAL-GL (NCT05747781)
- Testing
- Pilot Phase: standardized behavioral task, Validation Phase: standardized behavioral task
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Leber Congenital Amaurosis 10, Blindness
Extension Study to Study PQ-110-001 (NCT03140969)
Subjects completing participation in study PQ-110-001 (EudraCT 2017-000813-22 / NCT03140969) will be given the opportunity to enroll into the extension study for continued dosing if available data support current and/or future…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Vision Disorders
- Trial name
- INSIGHT (NCT03913130)
- Testing
- QR-110
- Where
- 3 sites in United States, Belgium
- Volunteers
- 9 people
- Sponsor
- Laboratoires Thea
Hemianopia, Homonymous
Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia
This pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training.
- Trial name
- NCT06638619
- Testing
- Biofeedback Fixation Training, Saccadic Reading Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Exotropia
Observation Versus Occlusion Therapy for Intermittent Exotropia
The present study is being conducted to assess the natural history of intermittent exotropia and to establish the effectiveness of occlusion in its treatment.
- Trial name
- IXT2 (NCT01032330)
- Testing
- occlusion treatment
- Where
- 2 sites in United States
- Volunteers
- 611 people
- Sponsor
- Jaeb Center for Health Research
Pregabalin, Optic Nerve Sheath Diameter Measurement
Effect of Pregabalin on Optic Nerve Sheath Diameter in Craniotomy Patients.
When patients undergo brain tumor removal surgery (craniotomy), the pressure inside the skull may increase, which can lead to brain swelling and slower recovery.
- Conditions
- Pregabalin, Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Changes
- Trial name
- NCT07630753
- Testing
- Pregabalin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma
Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Phase I trial to study the effectiveness of flavopiridol in treating children who have relapsed or refractory solid…
- Conditions
- Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma
- Trial name
- NCT00012181
- Testing
- alvocidib, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)