Clinical trials: Optic Neuropathy, Ischemic
Blindness
Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours
The purpose of this study is to provide data that would give the investigators a better understanding of the physiologic changes that occur and may contribute to post operative blindness.
- Trial name
- NCT00875043
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Nonarteritic Anterior Ischemic Optic Neuropathy
Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy
The purpose of this study is to explore the safety and efficacy of ranibizumab to treat non-arteritic ischemic optic neuropathy based on clinical and anatomical findings.
- Trial name
- NAION (NCT00561834)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Ischemic Optic Neuropathy/Optic Nerve Stroke
NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement
Ciliary Neurotrophic Factor (CNTF) has been demonstrated in multiple preclinical models to enhance survival and regeneration of retinal ganglion cells, the retinal neurons injured in diseases like ischemic optic neuropathy/optic…
- Trial name
- NCT01411657
- Testing
- NT-501 CNTF Implant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Jeffrey L Goldberg
Non Arteritic Ischemic Optic Neuropathy
A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Determine whether dalfampridine (Ampyra) can improve visual function in patients who have had nonarteritic ischemic optic neuropathy (NAION) with stable visual impairment.
- Trial name
- Ampyra (NCT01975324)
- Testing
- dalfampridine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Neuro-Ophthalmologic Associates, PC
Optic Neuropathy, Ischemic, Anterior Ischemic Optic Neuropathy
Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5%
The purpose of this study is to evaluate the feasibility of rapid evaluation and administration of ophthalmic Timolol maleate in the treatment of non-arteritic anterior ischemic optic neuropathy.
- Conditions
- Optic Neuropathy, Ischemic, Anterior Ischemic Optic Neuropathy, Ischemic Optic Neuropathy, Optic Neuropathy, Anterior Ischemic
- Trial name
- NCT01607671
- Testing
- Timolol maleate
- Where
- Canada
- Sponsor
- Fraser Health
NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy
Patients diagnosed with NAION within 14 days of onset were included. Patients were randomized into 3 groups. Group 1 or control consisted of 30 patients who received gelatinous capsules filled with sugar as placebo.
- Trial name
- NAION (NCT02439866)
- Testing
- Intravenous methylprednisolone, normobaric oxygen with face mask
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Blindness
Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry
This is a study to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively.
- Trial name
- NCT01219569
- Testing
- propofol, Sevoflurane
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Rutgers, The State University of New Jersey
Triamcinolone Acetonide, Optic Neuropathy, Ischemic
Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION
NAION produces an ischemic insult in the optic nerve head presumably due to the hypoperfusion of the short ciliary arteries that supply it.
- Trial name
- NCT02329288
- Testing
- Triamcinolone Acetonide
- Volunteers
- 60 people
- Sponsor
- Second Military Medical University
Non-arteritic Ischemic Optic Neuropathy
Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy
This present research project intends to collect five quantitative test series: perimetric examination using static stimuli, assessing the entire (80 degree) visual field with a fast thresholding algorithm (GATE) [Schiefer 2008]…
- Trial name
- Pilot-SINN (NCT01614158)
- Testing
- perimetry, D-BCVA, RAPD
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Problem With Vision Blindness, Intraocular Pressure
Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair
The objective of this study will be to answer a clinical question that has not already been investigated; that is, what are the effects of aortic infra-renal clamping and unclamping on intraocular pressure during Abdominal Aortic…
- Conditions
- Problem With Vision Blindness, Intraocular Pressure, Ischemic Optic Neuropathy
- Trial name
- NCT00450294
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Non-Arteritic Anterior Ischemic Optic Neuropathy
Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy
The goal of this pilot study is to evaluate the effect of Vision Restoration Therapy, VRT, on the visual function of patients with unilateral or bilateral AION, who have good central vision (at least 20/60) and altitudinal visual…
- Trial name
- NCT00140491
- Testing
- Vision Restoration Therapy (NOVAVISION)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Optic Atrophy, Non-arteritic Anterior Ischemic Optic Neuropathy
Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients
This is an open-label, dose escalation, safety, tolerability and pharmacokinetic study, where active study drug (QPI-1007) will be given to all patients who participate.
- Trial name
- NCT01064505
- Testing
- QPI-1007 at various doses
- Where
- 28 sites in United States, Israel
- Volunteers
- 48 people
- Sponsor
- Quark Pharmaceuticals
Retinitis Pigmentosa, Macula Off
Transcorneal Electrical Stimulation Therapy for Retinal Disease
Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
- Conditions
- Retinitis Pigmentosa, Macula Off, Primary Open Angle Glaucoma, Hereditary Macular Degeneration
- Trial name
- NCT00804102
- Testing
- Transcorneal Electrical Stimulation, DTL-electrode attached without energy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okuvision GmbH
Non-arteritic Anterior Ischemic Optic Neuropathy
Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy
Non-Arteritic Ischemic Optic Neuropathy (NAION) is a disease producing swelling of the optic nerve (the "cable" going from the eye to the brain) resulting in decreased vision.
- Trial name
- NCT00813059
- Testing
- Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Mount Sinai Hospital, Canada
Acute Nonarteritic Anterior Ischemic Optic Neuropathy
Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo
In this study 16 Patients diagnosed with Nonarteritic Anterior Ischemic Optic Neuropathy(NSION) who had a sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn in less than 30 days without…
- Trial name
- NCT01330524
- Testing
- Avastin and Triamcinolone
- Where
- Iran
- Volunteers
- 16 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Ischemic Optic Neuropathy
Ischemic Optic Neuropathy Decompression Trial (IONDT)
To assess the safety and efficacy of optic nerve sheath decompression surgery for non-arteritic ischemic optic neuropathy (NAION).
- Trial name
- NCT00000127
- Testing
- Optic Nerve Sheath Decompression Surgery
- Sponsor
- National Eye Institute (NEI)
Nonarteritic Anterior Ischemic Optic Neuropathy
Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy
Purpose: There are some controversies about the effect of Levodopa-Carbidopa on treatment of non-arteritic anterior ischemic optic neuropathy (NAION).
- Trial name
- NCT00432393
- Testing
- levodopa-carbidopa
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Non Arthritic Anterior Ischemic Optic Neuropathy
Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy
Non-arthritic anterior ischemic optic neuropathy is the most common cause of sudden visual loss due to optic nerve involvement in patients above 50 years old.
- Trial name
- NCT00372021
- Testing
- optic nerve neurotomy
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Ischemic Optic Neuropathy
Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup)
To follow all patients enrolled in the original Ischemic Optic Neuropathy Decompression Trial (IONDT) to determine (1) the incidence of non-arteritic ischemic optic neuropathy (NAION) in the second eye, (2) changes in visual…
- Trial name
- NCT00000126
- Testing
- Surgery
- Where
- 24 sites in United States
- Sponsor
- National Eye Institute (NEI)