Clinical trials: Optical Coherence Tomography
Pregnancy Induced Hypertension, Pregnancy Related
SD-OCT Measurement of the Human Retina in Pregnancy With Pre-existing or De Novo Hypertension and Without Hypertension
The complications of long-standing severe and acute severe elevations in systemic blood pressure (hypertension) may involve large vessels as well as smaller vessels, these latter comprising what is known as the microcirculation.
- Trial name
- NCT04286217
- Volunteers
- 155 people
- Sponsor
- University of Calgary
Glaucoma, Ocular Hypertension
SD-OCT Multimodal Analysis in GLaucoma
Glaucoma is the first cause of irreversible blindness worldwide with more than 60 millions people affected in 2010. It is defined as a neurodegenerative disease characterized by a progressive loss of retinal ganglion cells (RGC)…
- Conditions
- Glaucoma, Ocular Hypertension, Eye Diseases
- Trial name
- SOMAL (NCT02710916)
- Testing
- SD-OCT Spectralis
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Disease
Optical Coherence Tomography Evaluation of a Biodegradable Polymer-based Drug-eluting Stent
PONTINA aims at assessing by optical coherence tomography the neointimal coverage of the biodegradable polymer-based Biolimus A9-eluting stent (Biomatrix stent) after full drug elution and polymer biodegradation (6 months), at…
- Trial name
- PONTINA (NCT01060306)
- Where
- Italy
- Sponsor
- Ospedale Santa Maria Goretti
Epiretinal Membrane
Evaluation of the Cone Outer Segment Tips Line After Epiretinal Membrane Surgery
The recovery of the cone outer segment tips (COST) line after epiretinal membrane (ERM) surgery using spectral-domain optical coherence tomography (SD-OCT) was assessed.
- Trial name
- NCT01549249
- Testing
- optical coherence tomography
- Where
- Japan
- Volunteers
- 333 people
- Sponsor
- Kyorin University
Retinoschisis
Optical Coherence Tomography Evaluation of Retinoschisis and Retinal Detachment
Retinoschisis is usually a rare self-limited disease and seldom shows progression. There a splitting of the neurosensory retina occurs usually in the inferior temporal.
- Trial name
- NCT02682797
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Comparisons of Morphological Measurement Between Coronary Computed Tomography and Optical Coherence Tomography
The objective of this study is to evaluate the precision of semi-automated lumen boundary identification from coronary computed tomography angiography (cCTA) by current version of HeartFlow software and the impact on fractional…
- Trial name
- NCT03021382
- Testing
- data collection, non-intervention
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Kobe University
Cataract, Primary Open-angle Glaucoma
Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction
Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)
- Trial name
- NCT03889652
- Testing
- Oct scans
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Optical Coherence Tomography (OCT) of the Retina, Mutation
Looking for VUS to Confirm Dominant Wolfram-like Syndrome Instead of Recessive Wolfram Syndrome
Looking for the pthogenicity of mutations of WFS1 gene for patients with mutation of the two alleles but a dominant phenotype
- Trial name
- VUS in Wolfram (NCT07485413)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hôpital Necker-Enfants Malades
Sjogren's Syndrome, Tomography Optical Coherence
Histopathological Analysis Versus Full-field Optical Coherence Tomography of Minor Salivary Gland Biopsy in Suspect Sjogren Syndrome
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that mainly affects the exocrine glands leading to severe dryness of mucosal surfaces, principally in the mouth and eyes.
- Trial name
- TOCOSS (NCT06454370)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier de Mâcon
Bioresorbable Scaffolds
Performance of Bioabsorbable Vascular Scaffolds (Absorb) Compared to Xience Stents - an Optical Coherence Tomography Study
The biodegradable ABSORB scaffold is characterized by a greater strut thickness, but it has a greater flexibility compared to the XIENCE stent.
- Trial name
- NCT02001025
- Testing
- Absorb scaffold, Xience stent
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Rudolf Berger
Basal Cell Carcinoma
A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optical Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma
The purpose of this study is to find out if radiation therapy (RT) guided by the new reflectance confocal microscopy (RCM)/optical coherence tomography (OCT) device is an effective treatment for basal cell carcinoma (BCC).
- Trial name
- NCT05294120
- Testing
- Reflectance ConfocaL Microscopy And Optical Coherence Tomography Guided, Radiation Therapy
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Age Related Macular Degeneration (AMD), Age Related Macular Degeneration
Evaluating the Relationship Between Function and Structure Using Data From a GA Natural History Cohort
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration that leads to progressive and irreversible vision loss.
- Conditions
- Age Related Macular Degeneration (AMD), Age Related Macular Degeneration, AMD, Geographic Atrophy
- Trial name
- ARCHERY (NCT07424235)
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Coronary Artery Disease
ComparisiOn of Neointimal coVerage betwEen ZES and EES Using OCT at 3 Months
This study try to 1) evaluate the neointimal coverage and malapposition at 3 month after new zotarolimus eluting stent (Endeavor resolute) and everolimus eluting stent (Xience) implantation and 2) compare them between ZES…
- Trial name
- COVER OCT-II (NCT01091740)
- Testing
- ZES resolute (Endeavor Resolute), EES (Xience)
- Where
- 2 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Healthy Volunteers, Relative Afferent Pupil Defect
The PUPIL Study - Automated, Quantitative Pupil Assessment Using Binocular OCT
In current, clinical ophthalmology, a range of specialised testing allows comprehensive evaluation of ocular health. These tests have typically evolved over many years to ensure their clinical validity.
- Conditions
- Healthy Volunteers, Relative Afferent Pupil Defect, Pupil Anomaly
- Trial name
- NCT03081468
- Testing
- Binocular OCT prototype, Konan RAPDx
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Coronary Artery Disease, Coronary Artery Atherosclerosis
Intravascular Imaging Evaluated Calcified Nodule China Registry
What is this study about? This is a nationwide research study in China focused on understanding a specific type of challenging plaque in heart arteries called a Calcified Nodule (CN).
- Conditions
- Coronary Artery Disease, Coronary Artery Atherosclerosis, Coronary Calcified Nodules, Coronary Calcification
- Trial name
- NCT07262359
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Myopia
Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA
Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination are included. The Optical Coherence Tomography Angiography (OCTA) software automatically segments these full-thickness…
- Trial name
- NCT04631991
- Testing
- Comprehensive ophthalmologic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Akdeniz University
Coronary Heart Disease
Test of Long-Term Safety and Efficacy of Sirolimus-Permanent-Polymer Eluting Stent (Cypher)- and Sirolimus-Polymer-free Eluting Stents (PPS/PFS) Assessed by Optical Coherence Tomography
The objective of this pilot study is to compare the PFS-eluting stent (ISAR Rapa G1) with the PPS-eluting stent (Cypher®) regarding uncovered stent strut segments at 5 years.
- Trial name
- PPS/PFS-OCT (NCT01260558)
- Testing
- Sirolimus-Permanent-Polymer Eluting Stent, Sirolimus-Polymer-free Eluting Stent
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Hypertension, Diabetes Mellitus
Retinal Vascular Manifestations in Patients With Common Internal Diseases on OCTA Tomography Angiography
Hypertension, diabetes mellitus, and dyslipidemia are common internal diseases, and all diseases are atherosclerosis risk factors.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemias
- Trial name
- NCT05644548
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tongren Hospital
Eye Diseases, Diabetic Retinopathy
Deep Learning for Fluorescein Angiography and Optical Coherence Tomography Macular Thickness Map Image Translation
Diabetic macular edema (DME) is one of the leading causes of visual impairment in patients with diabetes. Fluorescein angiography (FA) plays an important role in diabetic retinopathy (DR) staging and evaluation of retinal…
- Trial name
- NCT05105620
- Testing
- Fluorescein Angiography, Optical coherence tomography
- Where
- Egypt
- Volunteers
- 708 people
- Sponsor
- Assiut University
Basal Cell Carcinoma
Training Health Care Professional in Detecting BCC on OCT Using E-learning and CUSUM-analysis
In this study, various health care professionals will follow an E-learning module in which BCC detection on OCT is explained. Thereafter, the participants will test their skill by assessing OCT-scans.
- Trial name
- NCT05634421
- Testing
- E-learning
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center