Clinical trials: Optical Neuritis
NMO Spectrum Disorder
Clinical Study of B001 Injection in Subjects With Neuromyelitis Optic Spectrum Disorder (NMOSD)
The objectives of this phase Ib study are to evaluate the efficacy, safety, pharmacokinetics, pharmacodynamics and immunogenic profiles of B001 in subjects with aquaporin-4 antibody (AQP4-IgG) positive NMOSD.
- Trial name
- NCT05145361
- Testing
- B001 injection
- Where
- 4 sites in China
- Volunteers
- 45 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Optic Nerve Disease
DTI & DIR in Optic Neuritis
To evaluate the role of Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI) in the assessment of optic neuritis and to correlate imaging findings with clinical and visual outcomes.
- Trial name
- DTI & DIR (NCT07748819)
- Testing
- MRI
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis, Neuromyelitis Optica
Lifestyle Weight Management Program: Interviews and Stakeholder Meetings.
Background: An assessment by paediatric neurologists specializing in demyelinating conditions brought attention to the rapid weight change seen among patients recently diagnosed with, and receiving therapy for, neuromyelitis…
- Trial name
- NCT05070286
- Testing
- Observational Study.
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Oxford Brookes University
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder
Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health
The goal of this observational study is to learn why some families have several members with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or MOG antibody-associated disease (MOGAD).
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, MOG Antibody-Associated Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NeuroDIP (NCT07902479)
- Testing
- Blood sampling and multi-omic profiling
- Where
- 5 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
NMO Spectrum Disorder
Efficacy and Safety of Baricitinib in Neuromyelitis Optica Spectrum Disorders
Neuromyelitis Optica Spectrum Disorders (NMOSD) is associated with a pathological humoral immune response against the aquaporin-4(AQP-4) water channel.
- Trial name
- NCT05792462
- Testing
- Baricitinib
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Tianjin Medical University General Hospital
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety of Conventional Immunosuppressant Therapies in Elderly Patients With Neuromyelitis Optica Spectrum Disorder
Newly diagnosed NMOSD patients
- Trial name
- NCT07032337
- Volunteers
- 2,985 people
- Sponsor
- Samsung Medical Center
Optic Neuritis, Optic Neuropathy
Prospective Evaluation of the 2022 Optic Neuritis Criteria When Optic Neuritis Is Suspected
Optic neuritis is an important cause of acute or subacute visual loss. In clinical practice, optic neuritis must often be distinguished from other optic neuropathies, retinal diseases, anterior-segment or ocular media disorders…
- Conditions
- Optic Neuritis, Optic Neuropathy, Visual Loss
- Trial name
- GX-ICON (NCT07623252)
- Where
- 9 sites in China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Optic Neuritis
Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
This study examines the effect of vitamin D on Retinal changes in patient with optic Neuritis.
- Trial name
- NCT01465893
- Testing
- Vitamin D, Vitamin D withheld
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Isfahan University of Medical Sciences
Devic's Syndrome, Devic's Neuromyelitis Optica
Autologous Mesenchymal Stem Cells for the Treatment of Neuromyelitis Optica Spectrum Disorders
Neuromyelitis optica (NMO) is a demyelinating and degenerative disorder of the central nervous system affecting vision and brain and spinal cord function which leads to accumulating disability with a 5 year-mortality of…
- Conditions
- Devic's Syndrome, Devic's Neuromyelitis Optica, Devic Syndrome, Devic's Disease
- Trial name
- NCT02249676
- Testing
- Autologous mesenchymal stem cells
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University General Hospital
Multiple Sclerosis, Optic Neuritis
Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis
The current study is a continuation of the 5 year extension study of the phase III CHAMPS study (see reference). This study was designed to determine if immediate initiation of therapy with Interferon Beta-1a (AVONEX) after a…
- Conditions
- Multiple Sclerosis, Optic Neuritis, Transverse Myelitis, Acute Brainstem/Cerebellar Syndrome
- Trial name
- CHAMPIONS10 (NCT00179478)
- Testing
- interferon beta 1a 30 ug IM once weekly
- Where
- 26 sites in United States, Canada
- Volunteers
- 155 people
- Sponsor
- Beth Israel Deaconess Medical Center
Neuromyelitis Optica, Restless Legs Syndrome
Restless Legs Syndrome in People With Neuromyelitis Optica Spectrum Disorder
Restless legs syndrome (RLS) is a neurological movement disorder characterized by uncomfortable and uncontrollable sensations, usually in the legs, that increase at rest, and an urge to move the legs or other affected…
- Trial name
- NCT05573711
- Testing
- assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dokuz Eylul University
Neuromyelitis Optica, Efgartigimod
Efgartigimod in Acute Neuromyelitis Optica Spectrum Disorders
This study aims to retrospective investigate the safety and effectiveness of Efgartigimod in the acute phase of neuromyelitis optica spectrum disorders (NMOSD) patients.
- Trial name
- NCT06118398
- Testing
- Intravenous methylprednisolone (IVMP) and Efgartigimod, IVMP
- Volunteers
- 24 people
- Sponsor
- Feng Jinzhou
Neuromyelitis Optica Spectrum Disorders
An Diagnostic Cohort on AQP4-Immunoglobulin G Detection Kit
The diagnostic cohort study could will be use to verify the clinical performance of the AQP4 -immunoglobulin G detection kit and whether it has a good correlation with the clinical diagnosis results.
- Trial name
- NCT04388072
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Optic Neuritis, Treatment
Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis Trial
A double-blind prospective randomized clinical trial of treatment for optic neuritis comparing visual outcome of patients treated by standard therapy (intravenous methylprednisolone) + placebo injection and standard therapy +…
- Conditions
- Optic Neuritis, Treatment, Methylprednisolone
- Trial name
- NCT04942002
- Testing
- Methylprednisolone Acetate 40 MG/ML [Depo-Medrol]
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asociación para Evitar la Ceguera en México
Progressive Multiple Sclerosis, Neuromyelitis Optica.
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica
Multiple sclerosis (MS) has been classically regarded as a chronic inflammatory autoimmune demyelinating disease of the central nervous system, along with a considerable pathological heterogeneity.
- Trial name
- NCT01364246
- Testing
- human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
Sclerosis, Multiple, Neuromyelitis Optica Spectrum Disorder
French Registry for Monitoring Pregnancies for Multiple Sclerosis
The influence of pregnancy on the course of multiple sclerosis (MS) has long been a controversial topic. After the publication of the first large prospective study of pregnancy and MS in 1998, counselling of women with MS has…
- Conditions
- Sclerosis, Multiple, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders, Pregnancy Abnormal
- Trial name
- RESPONSE (NCT03900221)
- Testing
- No intervention
- Where
- 48 sites in France, Martinique
- Volunteers
- 1,500 people
- Sponsor
- Hospices Civils de Lyon
NMO Spectrum Disorder, MRI
Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)
CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases.
- Conditions
- NMO Spectrum Disorder, MRI, Multiple Sclerosis, MOGAD
- Trial name
- NCT04106830
- Testing
- Intravenous steroid
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Transverse Myelitis, Neuromyelitis Optica
Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch)
Transverse myelitis (TM) is an inflammatory disorder of the spinal cord that leads to disabilities of gait. Dalfampridine, a sustained-release potassium inhibitor has been shown to be effective in improving gait and other…
- Conditions
- Transverse Myelitis, Neuromyelitis Optica, Idiopathic Transverse Myelitis, Myelitis NOS
- Trial name
- NCT02166346
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Optic Neuritis
Efgartigimod for the Treatment of Acute Optic Neuritis
The goal of this pilot clinical trial is to test efgartigimod alfa against placebo in adults with first-time optic neuritis (optic nerve inflammation).
- Trial name
- PET-AON (NCT06453694)
- Testing
- Efgartigimod Alfa
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Anastasia Vishnevetsky, MD, MPH
Optic Neuritis, Multiple Sclerosis
Neuroprotection With Phenytoin in Optic Neuritis
Optic neuritis is caused by inflammation of the optic nerve and causes loss of vision in the affected eye. It is often associated with multiple sclerosis.
- Trial name
- NCT01451593
- Testing
- Phenytoin
- Where
- 2 sites in United Kingdom
- Volunteers
- 92 people
- Sponsor
- University College, London