Clinical trials: Oral
Oral Cavity Squamous Cell Carcinoma, Oral Squamous Cell Carcinoma
Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002)
The study is being conducted to evaluate the efficacy and safety of sintilimab in combination with reduction of cycles of chemotherapy (carboplatin and nab-paclitaxel) in patients with oral cavity or oropharyngeal squamous cell…
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Oral Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT05098119
- Testing
- Sintilimab, Nab-paclitaxel, Carboplatin, Surgical resection, Sintilimab
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dental Plaque, Gingivitis
Plaque Reduction Sesame Oil
The goal of this clinical trials to learn about potential additives in reducing dental plaque. The main questions it aims to answer is: is there a difference in the plaque reducing effect of oil pulling with sesame oil compared…
- Conditions
- Dental Plaque, Gingivitis, Oral Microbial Colonization
- Trial name
- NCT06327841
- Testing
- sesame oil, distilled water
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University Innsbruck
Oral Cavity Squamous Cell Carcinoma
Biofeedback Rehabilitation to Improve Speaking and Eating in Public
Tongue cancer requires resection and reconstruction that can leave patients disabled with respect to speaking and eating. Impairment of tongue function can have significant impact on social interaction and employment.
- Trial name
- Biofeedback (NCT03650699)
- Testing
- Electropalatography Biofeedback Training
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Oral Health, Oral Health Related Quality of Life
Inter-organizational Health Planning for Older Adults: Public Dental Care and Municipal Care
Patient participation is key for healthy ageing and essential in health planning and decision-making. Oral health is an important but sometimes neglected part of general health and there is little research on health planning in…
- Conditions
- Oral Health, Oral Health Related Quality of Life, Participation, Participation, Patient
- Trial name
- GAPA (NCT06310798)
- Testing
- Inter-professional team test
- Where
- Sweden
- Volunteers
- 360 people
- Sponsor
- Vastra Gotaland Region
Oral Health, Dental Care
Oral Health Recovery Group
The aim of the study is to test a brief, peer-led group-based oral health educational intervention - called the "Oral Health Recovery Group" - designed for individuals with psychiatric disabilities.
- Conditions
- Oral Health, Dental Care, Psychiatric Diagnosis
- Trial name
- NCT05864027
- Testing
- Peer-led Oral Health Recovery Group, Educational Video about Oral Health
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Michigan
Nasopharyngeal Carcinoma, Head and Neck Cancer
Plasma SAA1 Levels in Predicting Response to Radiotherapy-induced Oral Mucositis
Head and neck squamous cell carcinoma (SCC) is the sixth most common cancer worldwide, with more than 700,000 new cases and more than 350,000 deaths each year.
- Conditions
- Nasopharyngeal Carcinoma, Head and Neck Cancer, Radiotherapy-induced Oral Mucositis, Biomarker
- Trial name
- NCT06307314
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Oral Malodor
Clinical Study on Malodor
This 3-week clinical study was designed to investigate the clinical efficacy on oral malodor of a 0.454% stannous fluoride toothpaste with nitrate and pyrophosphate (referred to as SNAP) compared to Colgate Cavity Protection…
- Trial name
- NCT06300905
- Testing
- test product, Control product
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Leukoplakia, Oral
Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach
This research protocol is comparing the effectiveness of surgical excision to the "wait and see" approach for the management of oral leukoplakia and erythroleukoplakia in prevention of oral squamous cell carcinoma onset.
- Trial name
- NCT04858100
- Testing
- Surgical excision of the lesion, Wait and see approach
- Where
- 2 sites in Italy
- Volunteers
- 310 people
- Sponsor
- University of Milan
HIV, Dental Caries
An Educational Intervention Program to Improve the Oral Health of HIV-Positive Children in Kano, Nigeria.
The aim of this 2- arm randomized-control study is to determine the effect of an oral hygiene self care intervention on the oral health status and oral health-related quality of life (OHRQoL) of HIV-positive children (age: 8-16…
- Conditions
- HIV, Dental Caries, Quality of Life, Oral Disease
- Trial name
- NCT05540171
- Testing
- Oral health education and instructions/training for self-oral care
- Where
- Nigeria
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Aminu Kano Teaching Hospital
Oral Health
The Effect of Oral Sprays on Salivary pH
The aim of the study is to assess the effect of oral foams on salivary pH changes after Coca-cola consumption in young adults.
- Trial name
- NCT06148662
- Testing
- No intervention (negative control), Water (positive control), Dental foam "Biorepair PERIBIOMA"
- Where
- Russia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Osteoarthritis, Knee, Total Knee Arthroplasty
Oral Fluid vs IV Fluid After Primary TKA
The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Oral Fluid Replacement
- Trial name
- NCT06288815
- Testing
- Oral fluid, IV fluid
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Thammasat University Hospital
Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
Ibuprofen Inhibits Human Sweet Taste
The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism.
- Trial name
- NCT06291337
- Testing
- Inhibition of Sweet Taste by Ibuprofen Oral Rinses, Inhibition of Sweet Taste by Naproxen Oral Rinses
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Oral Neoplasm, Pharynx Cancer
Comparison Between a Standard Tube and the Ultra-thin Tritube for Intubation of the Trachea and for Maintaining Access to the Trachea After Anaesthesia, in Patients With an Expected Difficult Direct Laryngoscopy
The investigators compare the ease of intubation between a new ultra-thin endotracheal tube, "Tritube", and a standard endotracheal tube in patients with predictors of difficult laryngoscopy.
- Conditions
- Oral Neoplasm, Pharynx Cancer, Larynx Cancer
- Trial name
- Tritube (NCT03653039)
- Testing
- Tritube, Standard enditracheal tube
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Michael Seltz Kristensen
Oral Chemotherapy
Oncology - Bolstering Oral Agent Reporting Related to Distress
Individuals on oral chemotherapy (OC) often face many challenges requiring adequate informational support, monitoring, and management.
- Trial name
- ON-BOARD (NCT04984850)
- Testing
- Oral chemotherapy information and support
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McGill University
Clinical Decision Making, Tooth Extraction
On Adequacy of Referrals to Oral and Maxillofacial Surgery
Currently, an ongoing generational shift of the dental community in Sweden originates from an increased number of retiring dentists.
- Conditions
- Clinical Decision Making, Tooth Extraction, Referral and Consultation, Surgery, Oral
- Trial name
- NCT05845437
- Where
- Sweden
- Volunteers
- 624 people
- Sponsor
- Region Skane
Menstrual Cycle, Oral Contraceptive Use
Characterization of the Mechanical Properties of the Hamstring Muscle Group in Female.
The goal of this clinical trial is to precise the impact of menstrual cycle and physical activity on the hamstrings muscle function in healthy active women.
- Trial name
- MECA_CYCLE (NCT05802277)
- Testing
- Hamstring muscles function assessment
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- EZUS-LYON 1
Wound Heal, Oral Microbiome
Effect of Mouthwashes on Oral Wound Healing and Microbiome
The purpose of this clinical research study is to investigate if mouthwashes to be tested can affect oral mucosal wound healing and change the oral microbiome (bacteria colonization) or expression of selected biomarkers.
- Trial name
- NCT05270382
- Testing
- cetylpyridinium chloride
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Oral Leukoplakia
Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study
Aims: To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES: 1.
- Trial name
- QQA-FPD-PMML (NCT06256809)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Oral Cavity Squamous Cell Carcinoma; Readmission
Oral Cavity Squamous Cell Carcinoma and Readmission: Rates, Causes, and Risk Factors.
We sought to comprehend the rates and causes of unplanned hospital readmission within 60 days following oral cancer surgery
- Trial name
- NCT06259838
- Testing
- no intervention
- Where
- Saudi Arabia
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Abdulsalam Alqutub
Oral Microbiome Health
Efficacy of VRx MyBiotics Oral Lozenges
This study will test the efficacy of Viome's VRx MyBiotics Oral Lozenges at improving the oral microbiome.
- Trial name
- NCT05972330
- Testing
- VRx MyBiotics Oral Lozenges
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Viome