Clinical trials: Oral, open to volunteers
Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
This phase II trial studies the good and bad effects of the combination of drugs called cabozantinib and nivolumab in treating patients with melanoma or squamous cell head and neck cancer that may have spread from where it first…
- Conditions
- Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Trial name
- NCT05136196
- Testing
- Biopsy Procedure, Biospecimen Collection, Cabozantinib S-malate
- Where
- 232 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
This phase III trial compares the effect of adding cetuximab to pembrolizumab versus pembrolizumab alone in treating patients with head and neck squamous cell carcinoma (HNSCC) that has come back after a period of improvement…
- Conditions
- Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma, Metastatic Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT06589804
- Testing
- Biospecimen Collection, Cetuximab, Computed Tomography
- Where
- 202 sites in United States
- Volunteers
- 158 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer
Background: Head and neck cancers (HNCs) account for about 5% of all cancers worldwide. They grow in the mouth, throat, nasal cavity, or salivary glands. Prostate cancer is the most common cancer in men in the United States.
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Paranasal Sinus Neoplasms, Nasopharyngeal Carcinoma
- Trial name
- NCT07667400
- Testing
- SX-682, DTX
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Oral Frailty, Mild Cognitive Impairment (MCI)
Oral Motor and Cognitive Dual-Task Training (OMCDT) Program for Improving Oral and Cognitive Functions Among People With Oral Frailty
The goal of this clinical trial is to proposes a novel Oral Motor and Cognitive Dual-Task Training (OMCDT) program that combines both oral motor exercises and cognitive tasks to improve brain and oral function at the same time.
- Conditions
- Oral Frailty, Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
- Trial name
- OMCDT (NCT07733726)
- Testing
- Oral Motor and Cognitive Dual-Task Training (OMCDT), Oral motor exercise
- Where
- 2 sites in Hong Kong
- Volunteers
- 66 people
- Sponsor
- The Hong Kong Polytechnic University
Oral Hygiene in Patients With Fixed Orthodontic Appliances, Dental Plaque
Effectiveness of Personalized Digital Oral Health Intervention in Patients With Fixed Orthodontic Appliances.
This study will evaluate whether personalized digital oral-health education delivered through WhatsApp messages can improve oral hygiene in patients aged 16-25 years who wear fixed orthodontic appliances (braces).
- Conditions
- Oral Hygiene in Patients With Fixed Orthodontic Appliances, Dental Plaque, Gingivitis Infection
- Trial name
- PDHOI (NCT07910851)
- Testing
- Personalized Digital Oral Health Education via WhatsApp, Standard Oral-Hygiene Instructions
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kurdistan Higher Council of Medical Specialties
Oral Submucous Fibrosis
Autologous PRP Versus Triamcinolone Acetate in Patients With Oral Submucous Fibrosis
Oral submucous fibrosis (OSF) is a chronic condition that causes stiffness of the oral tissues, reduced cheek flexibility, and difficulty opening the mouth.
- Trial name
- PRP OSF (NCT07914504)
- Testing
- Autologous Platelet-Rich Plasma, Triamcinolone Acetate
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Allama Iqbal Medical College
Psoriasis, Arthritis, Psoriatic
Comparing the Extent to Which Apremilast is Made Available in the Body After Administration as an Extended-release or Immediate-release Formulation
The main objective of this study is to compare the relative bioavailability, safety, and tolerability of extended-release and immediate-release apremilast formulations in healthy participants.
- Conditions
- Psoriasis, Arthritis, Psoriatic, Oral Ulcer
- Trial name
- NCT07908641
- Testing
- Apremilast XR, Apremilast IR
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Amgen
Oral Lichen Planus
Curcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus
Background: Oral Lichen Planus (OLP) is a chronic, T-cell-mediated inflammatory disease of the oral mucosa, with the erosive form causing painful ulcerations and erosions, significantly impacting the patient's quality of life and…
- Trial name
- NCT07910175
- Testing
- Nano- Curcumin-Mediated Photodynamic Therapy (PDT), Photobiomodulation Therapy (PBM)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Alexandria University
Oral Mucositis (Ulcerative) Due to Radiation, Nasopharyngeal Carcinoma (NPC)
Taurine for the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma
This clinical trial aims to understand whether taurine can prevent and reduce severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing radiotherapy.
- Trial name
- NCT07567742
- Testing
- Taurine
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Sun Yat-sen University
Hearing Disorder, Oral Mucosal Disease
Biospecimen Procurement for Head and Neck Disorders
Background: Researchers want to learn more about head and neck disorders. Understanding these disorders could help them find better treatments. To do this, they are collecting tissue samples for research.
- Conditions
- Hearing Disorder, Oral Mucosal Disease, Pharyngeal Neoplasm, Head and Neck Neoplasms
- Trial name
- NCT03429036
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma
Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
This phase I trial tests the safety, side effects, and best dose of camonsertib in combination with stereotactic body radiation therapy in controlling disease in patients with head and neck squamous cell cancer that has come back…
- Conditions
- Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT07156227
- Testing
- Biospecimen Collection, Camonsertib, Computed Tomography
- Where
- 4 sites in United States
- Volunteers
- 39 people
- Sponsor
- National Cancer Institute (NCI)
Oral Ulcer, Oral Mucositis
A Study of Phenytoin Mucoadhesive Film for Oral Ulcers in Healthy Volunteers
The goal of this clinical trial is to learn if a new 1% Phenytoin mucoadhesive film is safe and works to treat oral ulcers in healthy adult volunteers and patients with oral ulcers.
- Conditions
- Oral Ulcer, Oral Mucositis, Aphthous Stomatitis
- Trial name
- PHENO-FILM (NCT07890428)
- Testing
- 1% Phenytoin Mucoadhesive Film, Blank Mucoadhesive Film
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Oral Cavity Carcinoma, Flap
Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers
Patients with oral cavity cancer treated by reconstructive surgery with a flap. Patients will be treated in the study for : Experimental arm: Post-operative radiotherapy with flap sparing Control arm: Standard post-operative…
- Conditions
- Oral Cavity Carcinoma, Flap, Radiotherapy, Adjuvant, Reconstruction Surgery
- Trial name
- OPTIFLAP (NCT06798922)
- Testing
- Standard post-operative radiotherapy without flap sparing (current practice), Post-operative radiotherapy with flap sparing
- Where
- 30 sites in France
- Volunteers
- 348 people
- Sponsor
- Centre Francois Baclesse
Oral Squamous Cell Carcinoma (OSCC), Postoperative Pain
Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer
This randomized, double-blind, parallel-group controlled trial evaluates the effectiveness of hydrogen water oral care on acute oral inflammation, oral microbiota, and pain in patients with oral cancer who have undergone free…
- Conditions
- Oral Squamous Cell Carcinoma (OSCC), Postoperative Pain, Postoperative Oral Mucositis, Free Flap Reconstruction
- Trial name
- NCT07306546
- Testing
- Hydrogen Water Oral Care, Water Oral Care
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Locally Advanced Hypopharyngeal Squamous Cell Carcinoma, Locally Advanced Laryngeal Squamous Cell Carcinoma
Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Advanced Head and Neck Cancer Who Cannot Receive Cisplatin
This phase III trial compares cetuximab to chemotherapy, carboplatin and paclitaxel, with intensity modulated radiation therapy for the treatment of patients with head and neck cancer that may have spread from where it first…
- Conditions
- Locally Advanced Hypopharyngeal Squamous Cell Carcinoma, Locally Advanced Laryngeal Squamous Cell Carcinoma, Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Advanced Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT07441681
- Testing
- Biospecimen Collection, Carboplatin, Cetuximab
- Where
- 150 sites in United States
- Volunteers
- 454 people
- Sponsor
- NRG Oncology
Edentulous Mouth, Quality of Life
Changes in Oral Health-related Quality of Life (OHRQoL) During Full Arch Implant Treatment
Full-arch implant-supported fixed dental prostheses are a widely accepted treatment for edentulous patients, with high long-term implant survival rates.
- Conditions
- Edentulous Mouth, Quality of Life, Tooth Loss, Oral Health Quality of Life (OHQoL) Was Assessed
- Trial name
- NCT07568249
- Testing
- Full Arch Implant Surgery, Full arch prosthesis
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Implantology Institute
Head & Neck Cancer, Oral Mucositis
A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer.
Most patients who receive radiation therapy for head and neck cancer develop painful sores in the mouth called oral mucositis. For many of them, these sores are severe and result in debilitating pain.
- Trial name
- BEAM-Pain (NCT07672236)
- Testing
- BupiZenge 25 mg, Lidocaine viscous 2%
- Where
- 11 sites in Denmark, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- OncoZenge AB
Oral Health-Related Quality of Life
Manus AI-Assisted Orthodontic Education and Oral Health-Related Quality of Life
The goal of this clinical trial is to learn whether adding artificial intelligence (AI)-assisted education to standard orthodontic education can improve quality of life in adults starting treatment with fixed braces.
- Trial name
- NCT07832604
- Testing
- Conventional Orthodontic Education, Manus AI-Assisted Orthodontic Education
- Volunteers
- 230 people
- Sponsor
- University of Malaya
Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma
Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer
This phase II trial compares the effectiveness of cemiplimab with CDX-1140 to cemiplimab without CDX-1140 prior to surgery in treating patients with stage III-IV head and neck cancer.
- Conditions
- Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Nasal Cavity Squamous Cell Carcinoma
- Trial name
- NCT06980038
- Testing
- Anti-CD40 Agonist Monoclonal Antibody CDX-1140, Biopsy Procedure, Biospecimen Collection
- Where
- 12 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Cancer Institute (NCI)
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer
This phase II trial tests the addition of chemotherapy, with carboplatin and paclitaxel, or chemo-immunotherapy, with carboplatin, paclitaxel and cemiplimab to standard salvage surgery followed by post operative radiation therapy…
- Conditions
- Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Locally Recurrent Head and Neck Squamous Cell Carcinoma, Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma
- Trial name
- NCT07195734
- Testing
- Biospecimen Collection, Carboplatin, Cemiplimab
- Where
- 115 sites in United States
- Volunteers
- 180 people
- Sponsor
- National Cancer Institute (NCI)