Clinical trials: Oral Bacterial Infection
Tuberculosis Infection, Tuberculosis
BCG Revaccination in Children and Adolescents
Bacille Calmette Guerin (BCG) vaccine is one of the most used vaccines of the world, to reduce the risks of natural tuberculous infection.
- Trial name
- BRiC (NCT05330884)
- Testing
- BCG vaccine, Oral Chemoprophylaxis
- Where
- India
- Volunteers
- 9,200 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Research Centre, India
Bacterial Infections Oral
PLGA Nanoparticles Entrapping Ciprofloxacin to Treat E-Fecalis Infections in Endodontics
PLGA nanoparticles coated with Chitosan polymer were prepared and then incorporated in In -situ gel to be injected to root canals of patients suffered from bacterial infection of their endodontics.
- Trial name
- NCT05475444
- Testing
- Chitosan Coated PLGA nanoparticles entrapping Ciprofloxacin incorporated in smart gels, Ciprofloxacin paste and solution
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- British University In Egypt
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Two Irrigation Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection, Irrigation Activation
- Trial name
- NCT05690763
- Testing
- XP-endo Finisher to use irrigation activation, EndoActivator to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Cholera
Immune Non-Inferiority, Safety and Lot-to-Lot Consistency of Oral Cholera Vaccine-Simplified Compared to Shanchol™
This study is to evaluate immune non-inferiority, safety and lot-to-lot consistency of OCV-S compared to Shanchol™ in 1 to 40 years old healthy Nepalese participants.
- Trial name
- NCT04760236
- Testing
- Oral Cholera Vaccine Simplified (OCV-S), Shanchol™
- Where
- 4 sites in Nepal
- Volunteers
- 2,530 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Hansen's Disease
Virgin Coconut Oil Oral Supplementation for Leprosy Patients
To date, there has been no clinical investigation on the effects of virgin coconut oil (VCO) oral supplementation on patients with Hansen's disease (HD) undergoing medical treatment.
- Trial name
- NCT01885611
- Testing
- Multi-Drug Therapy (Novartis Ⓡ), Virgin Coconut Oil
- Where
- Philippines
- Sponsor
- Philippine Dermatological Society
Periapical Periodontitis, Root Canal Infection
Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria
This study evaluates intracanal bacterial load in molar teeth with chronic apical periodontitis before and after root canal shaping with two different apical enlargement sizes and ultrasonic irrigation activation.
- Trial name
- NCT07005219
- Testing
- Root canal shaping with One Curve Mini #25/0.4 and passive ultrasonic irrigation, Root canal shaping with One Curve Mini #35/0.4 and passive ultrasonic irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Smear Positive Pulmonary Tuberculosis
L-arginine and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis (TB)
The purpose of this study is to determine whether adjunctive L-arginine and vitamin D can improve response to standard short course TB therapy in people with newly diagnosed pulmonary TB.
- Trial name
- AVDAPT (NCT00677339)
- Testing
- L-arginine, Vitamin D
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Menzies School of Health Research
Acute Bacterial Skin and Skin Structure Infections
Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
The objective of this study is to evaluate the efficacy and safety of oral NXL103 vs. established treatment of acute bacterial infection in adults.
- Trial name
- NCT00949130
- Testing
- NXL103, Linezolid
- Where
- 15 sites in United States, Guatemala
- Volunteers
- 180 people
- Sponsor
- Novexel Inc
Escherichia Coli Diarrhea
Enterotoxigenic Escherichia Coli (ETEC) ETVAX Vaccine Trial in Bangladesh
The purpose of this study is to determine if the ETEC vaccine ETVAX with and without dmLT adjuvant is safe and immunogenic in adults, children, toddlers and infants in Bangladesh.
- Trial name
- ETVAX/dmLT (NCT02531802)
- Testing
- ETVAX, dmLT, Bicarbonate Buffer
- Where
- Bangladesh
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- PATH
Clostridium Difficile-associated Diarrhea (CDAD)
A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)
The purpose of this study was to investigate the clinical response to fidaxomicin oral suspension or tablets and vancomycin oral liquid or capsules in pediatric participants with Clostridium difficile-associated diarrhea (CDAD).
- Trial name
- SUNSHINE (NCT02218372)
- Testing
- Fidaxomicin oral suspension, Fidaxomicin tablets, Vancomycin oral liquid
- Where
- 44 sites in United States, Belgium and 8 more
- Volunteers
- 148 people
- Sponsor
- Astellas Pharma Europe B.V.
Typhoid
Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults
This study is to investigate the safety, tolerability and immunogenicity of the typhoid fever vaccine candidate M01ZH09 manufactured at commercial scale, at a new manufacturing facility.
- Trial name
- NCT00679172
- Testing
- Dose of 5.0 x 10^9 CFU (Cohort 1), Dose of 7.5 x 10^9 CFU (Cohort 2), Dose of 1.1 x 10^10 CFU (Cohort 3)
- Where
- 3 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Anticoagulants; Circulating, Hemorrhagic Disorder
Activates Charcoal for Patients Undergoing Invasive Procedure Delayed Due to Direct Oral Anticoagulants
This is a prospective, multicentric, randomized, open labeled superiority trial This study aims to evaluate the efficacy of oral activated charcoal for improving elimination of direct oral anticoagulants ( Rivaroxaban, Apixaban)…
- Trial name
- CACAOD (NCT02969746)
- Testing
- Activated Charcoal
- Where
- 6 sites in France
- Sponsor
- University Hospital, Angers
Vaginitis Bacterial, Inflammation, Ear
Effect of Lactobacillus Johnsonii or White Pomegranate Extract on the Vaginal Health
The goal of this clinical trial is to explore the effect of Lactobacillus johnsonii and white pomegranate extract on female bacterial status, it aims to answer are: Evaluate Lactobacillus johnsonii TCI250 probiotics or white…
- Trial name
- NCT06069531
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chung Shan Medical University
Erythema Migrans
Culture Media for Borrelia Burgdorferi Sensu Lato
The main purpose of this study is to compare effectiveness of two different culture media for cultivation of Borrelia burgdorferi sensu lato from skin specimens obtained from patients with erythema migrans.
- Trial name
- NCT02145754
- Testing
- MKP media, BSK-H media
- Where
- Slovenia
- Volunteers
- 235 people
- Sponsor
- University Medical Centre Ljubljana
Shigella
Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa
The purpose of this study is to determine whether CVD 1208S (a live, attenuated, oral vaccine) is safe and effective in the prevention of Shigella infection.
- Trial name
- NCT00866476
- Testing
- CVD 1208S, a Shigella flexneri 2a live, oral vaccine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Bacterial Vaginosis
Analysis of Ameliorative Effects of Oral Probiotics on Bacterial Vaginosis
The purpose of this study is to analyze the ameliorative effects of oral probiotics on bacterial vaginosis.
- Trial name
- NCT03116789
- Testing
- probiotics
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- GenMont Biotech Incorporation