Clinical trials: Oral Biofilm
Oral Hygiene, Oral Health, Pediatric Pain and Anxiety
Efficacy of Guided Biofilm Therapy in Pediatric Patient
The present parallel randomized clinical trial aims to assess the efficacy of a plaque disclosing agent (PDA) and air-flowing with erythritol powder (Guided Biofilm Therapy) in the removal of biofilm and plaque in paediatric…
- Trial name
- BABYPLAK (NCT06765343)
- Testing
- Plaque disclosing agent, Guided Biofilm Therapy, Ultrasonic debridement and polishing
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Gingivitis, Malocclusion
Dental Biofilm Control During Orthodontic Treatment
Orthodontic appliances can affect changes in the relationships of members of the oral microbiome. Microbiome imbalance can result in oral infections and complicate treatment.
- Trial name
- ORTHOBIOFILM (NCT05532241)
- Testing
- fixed metal orthodontic appliance, fixed non-metal orthodontic appliance, oral hygiene
- Where
- 3 sites in Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Periodontitis, Adult
Protozoans in Biofilm From Patients With Periodontitis
The buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients.
- Trial name
- Paro-Proto (NCT03240666)
- Testing
- non applicable
- Where
- France
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Gingivitis
Effectiveness of Black Tea Mouthwash on Plaque Formation
The study was conducted to measure the effectiveness of Black Tea in reducing the deposits on teeth. It also compares the effect between use of black tea mouthwash and green tea mouthwash to that of chlorhexidine in reducing…
- Trial name
- Blacktea (NCT02545244)
- Testing
- Black Tea, Green Tea, 0.12% Chlorhexidine Mouthwash.
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sri Hasanamba Dental College and Hospital
Plaque, Dental, Gingivitis
Imaging-based Assessment of Oral Biofilm and Gingival Health
The purpose of this research study is to develop a better way of measuring the health of patients' mouth using photographs and imaging software.
- Trial name
- NCT05470023
- Testing
- OTC Toothpastes or Mouthrinses
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Epilepsy, Gingivitis
Air Polishing Effect on Biological, Clinical and Patient-reported Experience Among Epileptic and Non-epileptic Children
In epileptic and non Epileptic children, the full dentition of each patient was split into four quadrants, starting from the upper right quadrant (1) and moving clockwise until the lower right quadrant (4).
- Trial name
- NCT06144034
- Testing
- Air polishing with erythritol powder, Conventional treatment
- Where
- 2 sites in Jordan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Periodontal Diseases
Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract.
Background: For centuries, plants (and / or their products) were the only resource available for the prevention and treatment of many diseases.
- Trial name
- NCT05138484
- Testing
- experimental group 10% mouthwash of M. sylvestris extract
- Where
- Chile
- Volunteers
- 54 people
- Sponsor
- Aravena, Pedro, DDS, PhD
Periodontitis
Effect of Supragingival Control Versus Supra- and Subgingival Control in the Periodontal Health During the Maintenance
Seventy patients will be previously treated for moderate-to-severe periodontitis according to their individual needs. Thirty days after completion of periodontal treatment, these patients will be randomized to one of the…
- Trial name
- NCT01598155
- Testing
- Group 1 - Supragingival biofilm control, Group 2 - Supra- and subgingival biofilm control
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of Rio Grande do Sul
Candida Infection, Denture Stomatitis
The Anti-microbial Effect of Titanium Dioxide Nano Particles in Complete Dentures Made for Edentulous Patients
Although cleaning dentures by immersion in chemical denture cleaning solutions is effective in reducing the number of bacteria, a large number remains adhering to the denture surface.
- Trial name
- NCT03666195
- Testing
- Titanium Dioxide Nanoparticles
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis
Non-Invasive Oral Biofilm Characterization
There is a need for toothpastes that more effectively remove oral plaque and prevent re-formation. The objective of this study is to map the development and resolution of clinical gingivitis using conventional clinical…
- Trial name
- NCT02178046
- Testing
- optical measurements
- Where
- United States
- Sponsor
- University of California, Irvine
Gingivitis, Periodontitis
A Clinical and Imaging Study to Evaluate a Novel Dentifrice
There is a need for toothpastes that more effectively remove oral biofilm, inhibit biofilm re-formation and support periodontal health.
- Conditions
- Gingivitis, Periodontitis, Dental Plaque
- Trial name
- NCT02271815
- Testing
- Oral Hygiene
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of California, Irvine
Oral Biofilm, Dental Plaque
Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect
The Essential oils (EO) are composed by a wide diversity of products. Therefore, their antimicrobial activity will be related to their composition, configuration, amount and their possible interaction.
- Conditions
- Oral Biofilm, Dental Plaque, Periodontitis
- Trial name
- NCT03146390
- Testing
- Essential oils, Alcohol free essential oils, Water
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Chlorhexidine, Gingivitis
Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients
The present study compares the effectiveness of two mouthwash formulations (0.12% CHX and 0.05% CHX+0.05%CPC) in reducing gingival inflammation and microbial colonization in individuals with gingivitis and in preventing…
- Conditions
- Chlorhexidine, Gingivitis, Periodontitis, Cetylpyridinium Chloride
- Trial name
- NCT06411522
- Testing
- Mouthwash containing 0.12% CHX (Chlorhexidine), Mouthwash containing 0.05% CHX (Chlorhexidine) and 0.05% CPC (Cetylpyridinium Chloride)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Siena
Dental Plaque, Gum Bleed
Effect of Professional Prophylaxis on Clinical Parameters and Patient Comfort: Randomized Slipt-Mouth Clinical Trial
The goal of this clinical trial is to evaluate whether the Guided Biofilm Therapy (GBT) protocol can improve or maintain oral health and whether it provides more comfort to patients compared to a conventional protocol.
- Trial name
- NCT06936306
- Testing
- GBT, Master, scalling
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Breast Cancer, Gingivitis
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer
Objective: To evaluate the impact of chemotherapy on periodontal conditions, hematology, and salivary flow in patients with breast cancer and gingivitis, after basic periodontal therapy (BPT).
- Conditions
- Breast Cancer, Gingivitis, Periodontal
- Trial name
- BREASTCANCER (NCT06212908)
- Testing
- Basic Periodontal Therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peri-implant Mucositis
Effectiveness of Interproximal Cleaning Devices for Biofilm Removal Around Posterior Single Implants With Peri-Implant Mucositis
This randomized clinical trial aims to evaluate and compare the efficacy of different interproximal oral hygiene devices for biofilm removal around posterior single dental implants in patients diagnosed with peri-implant…
- Trial name
- NCT07393828
- Testing
- Participants assigned to this intervention group are instructed to perform daily interproximal plaque control around implant-supported crowns using the allocated interdental oral hygiene device (inter
- Volunteers
- 75 people
- Sponsor
- Universitat Internacional de Catalunya
Peri-implant Mucositis
Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis
the objective of this study is to determine the incidence of peri-implant mucositis in patients with treated periodontitis and enrolled in periodontal maintenance and to evaluate the associated risk indicators.
- Trial name
- PiM_Inc (NCT05356806)
- Testing
- Supportive periodontal and periimplant care
- Where
- Spain
- Volunteers
- 277 people
- Sponsor
- Universidad Complutense de Madrid
Treatment of Periodontitis, Guided Biofilm Therapy
Comparison of Current Subgingival Debridement Methods
Our study aimed to compare the effectiveness of current subgingival debridement methods used in the treatment of Stage 1 and Stage 2 periodontitis patients, the aesthetic condition achieved after these treatments, and the pain…
- Conditions
- Treatment of Periodontitis, Guided Biofilm Therapy, Subgingival Plaque, Subgingival Debridement
- Trial name
- NCT06835452
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Oral Rehabilitaiton, Caries
a Clinical Study.the Effect of Addition of Insoluble Antibacterial Nanoparticles(IABN) in Resin Base Provisional Cement
The effect of Antibacterial Nanoparticles, Incorporated in cement, on S.mutans in the margins of provisional restorations is going to be examined clinically by using two kinds of provisional cement 1.
- Conditions
- Oral Rehabilitaiton, Caries, Periodontitis
- Trial name
- IABN (NCT00502606)
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization