Clinical trials: Oral Biofilm, open to volunteers
Dental Plaque, Oral Biofilm
Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns
This in-vivo study investigates early (48h), mature (2 weeks) and long-term (3 months) biofilm formation and composition on temporary push-on cones (exchangeable conical rings) made of noble-alloy-based materials (Pagalinor, PA)…
- Conditions
- Dental Plaque, Oral Biofilm, Peri-implantitis
- Trial name
- NCT05122897
- Testing
- Rings made of PA (test), Rings made of TAN (control)
- Where
- Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Plaque-Induced Gingivitis
Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis
The goal of this clinical trial is to determine whether a mouthwash made from thyme (Thymus vulgaris) helps improve gum health in people with plaque-induced gingivitis.
- Trial name
- NCT07905456
- Testing
- 0.2% Thymus vulgaris mouthwash, Chlorhexidine 0,12%
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- University of Sulaimani
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Periodontal Diseases, Periodontitis and Treatment Need
Micro-Needling Technique Using Ozonated Olive Oil in Periodontal Diseases
The research idea is based on using micro-acupuncture therapy with ozone-treated olive oil to improve the condition of patients suffering from gingivitis and periodontitis and comparing it to the scientifically proven…
- Conditions
- Periodontal Diseases, Periodontitis and Treatment Need, Gingivitis
- Trial name
- NCT06990282
- Testing
- microneedling, scaling, Ozonated olive oil
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Fayoum University
Dental Caries, Periodontitis
Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
- Conditions
- Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission
- Trial name
- NCT07674888
- Testing
- Professional Dental Plaque Disruption
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Peri-implant Mucositis
Effectiveness of Interproximal Cleaning Devices for Biofilm Removal Around Posterior Single Implants With Peri-Implant Mucositis
This randomized clinical trial aims to evaluate and compare the efficacy of different interproximal oral hygiene devices for biofilm removal around posterior single dental implants in patients diagnosed with peri-implant…
- Trial name
- NCT07393828
- Testing
- Participants assigned to this intervention group are instructed to perform daily interproximal plaque control around implant-supported crowns using the allocated interdental oral hygiene device (inter
- Volunteers
- 75 people
- Sponsor
- Universitat Internacional de Catalunya
Peri-implant Mucositis
Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis
the objective of this study is to determine the incidence of peri-implant mucositis in patients with treated periodontitis and enrolled in periodontal maintenance and to evaluate the associated risk indicators.
- Trial name
- PiM_Inc (NCT05356806)
- Testing
- Supportive periodontal and periimplant care
- Where
- Spain
- Volunteers
- 277 people
- Sponsor
- Universidad Complutense de Madrid
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Pit and Fissure Sealant Retention, Dental Caries
Clinical Evaluation of the Retention of Fissure Sealants Applied Following Guided Biofilm Therapy and Conventional Polishing
This randomized split-mouth clinical trial will compare two methods of occlusal surface cleaning before pit and fissure sealant placement in children aged 6-10 years.
- Trial name
- NCT07725133
- Testing
- Device: Guided Biofilm Therapy with erythritol, Device: Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis
Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients
The goal of this clinical trial is to investigate the clinical and biochemical effects of the guided biofilm therapy protocol as an alternative to the conventional non-surgical periodontal therapy in patients with periodontitis.
- Trial name
- NCT07286916
- Testing
- Root surface debridement, Guided Biofilm Therapy
- Where
- Iraq
- Volunteers
- 18 people
- Sponsor
- University of Baghdad
Plaque, Dental, Gingivitis
Imaging-based Assessment of Oral Biofilm and Gingival Health
The purpose of this research study is to develop a better way of measuring the health of patients' mouth using photographs and imaging software.
- Trial name
- NCT05470023
- Testing
- OTC Toothpastes or Mouthrinses
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
pH, Microbiome
Oral Changes With Caloric and no Caloric Sweeteners
The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm…
- Conditions
- pH, Microbiome, Dental Plaque
- Trial name
- NCT05852145
- Testing
- Stevioside, Sucrose, Natural water
- Where
- Mexico
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Peri-implantitis, Dental Implants
Natural Bioactive Gel for Peri-Implantitis
This study is a randomized controlled clinical trial using a split-mouth design to evaluate the effectiveness of a natural bioactive gel (Sterify Gel®) as an adjunct to standard non-surgical therapy for peri-implantitis.
- Conditions
- Peri-implantitis, Dental Implants, Non-surgical Periodontal Therapy
- Trial name
- PERISTER (NCT07088679)
- Testing
- Sterify Gel (mucoadhesive bioactive gel), Standard Non-Surgical Peri-Implantitis Therapy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Pavia
Apical Periodontitis, Endodontic Disease
Nanozymes in Endodontics
The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment.
- Conditions
- Apical Periodontitis, Endodontic Disease, Root Canal Infection
- Trial name
- NCT07518901
- Testing
- Nanozyme treatment, Control (Standard treatment)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Poly(Lactide-co-glycolide) Sutures, Suture Resorption
Comparative Analysis of fast-and Slow-absorbable Poly(Lactose-co-glycolide) Sutures in Oral Surgery: a Randomized Controlled Trial.
This study aims to compare slow-resorbing and fast-resorbing sutures used after the surgical extraction of lower third molars. Sutures are routinely placed after wisdom tooth removal to promote hemostasis.
- Conditions
- Poly(Lactide-co-glycolide) Sutures, Suture Resorption, Third Molar Surgery
- Trial name
- NCT07498361
- Testing
- Fast absorbable sutures application, Standard absorbable sutures application
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine