Clinical trials: Oral Cavity Carcinoma
Carcinoma, Transitional Cell
Tesetaxel for Previously Treated Patients With Bladder Cancer
The intravenously administered taxanes, docetaxel and paclitaxel, alone and in combination with other chemotherapy agents are active in patients with advanced and metastatic bladder cancer, and agents of this class are a…
- Trial name
- NCT01215877
- Testing
- Tesetaxel
- Where
- 3 sites in United States, Italy
- Volunteers
- 33 people
- Sponsor
- Genta Incorporated
Head and Neck Cancer
Adjuvant Erlotinib After Completing Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Giving erlotinib after chemoradiotherapy may kill more tumor cells.
- Trial name
- NCT00079053
- Testing
- erlotinib hydrochloride, adjuvant therapy
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- NCIC Clinical Trials Group
Pancreatic Cancer, Cancer of the Duodenum
Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy
Pancreatoduodenectomy carries high morbidity rates even in high-volume centers. Postoperative complications often preclude or delay adequate oral nutrition and nutritional support may be required.
- Conditions
- Pancreatic Cancer, Cancer of the Duodenum, Cholangiocarcinoma, Chronic Pancreatitis
- Trial name
- NCT01642875
- Testing
- Enteral nutrition, Oral nutrition
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw
Head and Neck Cancer, Infection
Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract
RATIONALE: It is not yet known which regimen of enteral nutrition is more effective in preventing infections in patients undergoing surgery for cancer of the upper aerodigestive tract.
- Conditions
- Head and Neck Cancer, Infection, Malnutrition
- Trial name
- NCT00765440
- Testing
- therapeutic nutritional supplementation
- Where
- France
- Volunteers
- 311 people
- Sponsor
- Centre Antoine Lacassagne
Mouth Neoplasms, Carcinoma, Squamous Cell
A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients
To confirm the subgroup result from TPF (docetaxel, cisplatin and 5-fluorouracil ) trial (NCT01542931) that cN2 OSCC patients could benefit from TPF induction chemotherapy compared to the standard treatment.
- Trial name
- NCT02285543
- Testing
- TPF induction chemotherapy, surgery, radiotherapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Dysphagia
Multifunctional Nutrition Tube in Dysphagia for Nasopharyngeal Carcinoma
Baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life (QOL) after treatment as well as adverse events are compared.
- Trial name
- NCT06328868
- Testing
- Intermittent Oral-esophageal Tube Feeding, Nasogastric Tube Feeding, comprehensive rehabilitation therapy
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Head and Neck Neoplasms, Carcinoma, Squamous Cell
Platinum-based Chemoradiotherapy and Rigosertib in Head and Neck Cancer
The working hypothesis is that oral rigosertib treatment when added to platinum-based Chemoradiotherapy (CRT) will improve progression-free survival for first-line patients with intermediate- or high-risk human papillomavirus…
- Trial name
- NCT02107235
- Testing
- oral rigosertib, cisplatin, Radiotherapy
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Traws Pharma, Inc.
Squamous Cell Carcinoma of the Oropharynx, Squamous Cell Carcinoma of the Larynx
Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
The purpose of this study is to find out if the combination of two established anti-cancer therapies are beneficial in participants with Head and Neck Squamous Cell Carcinoma (HNSCC).
- Conditions
- Squamous Cell Carcinoma of the Oropharynx, Squamous Cell Carcinoma of the Larynx, Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT03370276
- Testing
- Nivolumab, Cetuximab
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Advanced or Metastatic Solid Tumors
Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors
This is a first-in-human, open label, multicenter, dose escalation study of RXDX-106 in patients with locally advanced or metastatic solid tumors, who have no available therapy likely to convey clinical benefit.
- Trial name
- TITAN (NCT03454243)
- Testing
- RXDX-106
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Hoffmann-La Roche
Pancreatic Cancer
Boost GVAX Pancreas Vaccine With or Without CY in Patients With Pancreas Cancer
The purpose of this study is to evaluate the safety and feasibility of long term boost vaccination of a lethally irradiated, allogenic pancreatic tumor cell vaccine transfected with the granulocyte macrophage colony-stimulating…
- Trial name
- NCT01088789
- Testing
- Cyclophosphamide, Cyclophosphamide Pill, GVAX Pancreas Vaccine
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head and Neck Cancer
Gene Therapy in Treating Patients With Recurrent Head and Neck Cancer
RATIONALE: Inserting the gene for p53 into a person's tumor may improve the body's ability to fight cancer or make the cancer more sensitive to chemotherapy.
- Trial name
- NCT00003257
- Testing
- Ad5CMV-p53 gene
- Where
- 10 sites in United States
- Volunteers
- 39 people
- Sponsor
- Aventis Pharmaceuticals
Squamous Cell Carcinoma of the Oral Cavity
Safety and Efficacy Study of GL-0817 (With Cyclophosphamide) for the Prevention of Recurrence of Squamous Cell Carcinoma of the Oral Cavity
This is a multi-center, randomized, double-blind clinical trial to assess the safety and efficacy of GL-0817 as a means to prevent disease recurrence in patients considered at high-risk following surgery and adjuvant…
- Trial name
- NCT02873819
- Testing
- GL-0817, Hiltonol, Sargramostim
- Where
- 33 sites in United States, Hungary and 5 more
- Volunteers
- 80 people
- Sponsor
- Gliknik Inc.
GM-CSF
The Effect of GM-CSF to Preventing Oral Mucositis for Patients With Nasopharyngeal Carcinoma Receiving Radiotherapy
To evaluate the efficacy of GM-CSF to preventing oral mucositis for patients with nasopharyngeal carcinoma receiving radiotherapy.
- Trial name
- NCT06472739
- Testing
- GM-CSF
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Head and Neck Cancer, Skin Reactions Secondary to Radiation Therapy
Biafine Cream to Reduce Side Effects of Radiation Therapy in Patients Receiving Treatment for Advanced Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells, but may cause skin irritation and inflammation. Biafine cream may be effective in lessening side effects caused by radiation therapy.
- Trial name
- NCT00006481
- Testing
- Biafine cream, quality-of-life assessment, radiation therapy
- Where
- 260 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Oral Mucositis
Study to Determine the Effects Treatment With Amlexanox 0.5% Oral Rinse Solution on Oral Mucositis Associated With Radiation Therapy for Cancer of the Head and Neck Region
The purpose of this study was to determine the effect of 0.5% amlexanox oral rinse compared to a vehicle control on mucositis-related ulceration and erythema (objective score)and on mucositis-related oral pain (subjective score).
- Trial name
- NCT01083875
- Testing
- amlexanox, Vehicle rinse
- Where
- 12 sites in United States
- Volunteers
- 58 people
- Sponsor
- Access Pharmaceuticals, Inc.
Oral Squamous Cell Carcinoma
Dissecting the Heterogeneity of Oral Cancer Pain
Oral squamous cell carcinoma (SCC) produces a higher prevalence and more severe pain than all other cancers. Orofacial pain is one of the most common initial symptoms of oral cancer and often leads to the diagnosis of oral…
- Trial name
- NCT05024383
- Testing
- Chemical sensitivity, Mechanical sensitivity
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Oral Squamous Cell Carcinomas
Tobacco, Alcohol and Cancerization of the Oral Mucosa (TACO)
The goal of this project is to describe somatic mutations of healthy oral mucosa from patients with oral squamous cell carcinoma (OSCC).
- Trial name
- TACO (NCT06425146)
- Testing
- Cytobrush sample, Blood sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Leon Berard
Carcinoma, Non-small-cell Lung
A Study of Paclitaxel and Carboplatin in Combination With Bexarotene Oral Capsules in Patients With Advanced Lung Cancer
The primary aim is to evaluate the safety (Phase I components) of administering bexarotene (Targretin®, LGD1069) oral capsules in combination with two Taxol® and carboplatin (Paraplatin®) schedules to patients with stage IIIB and…
- Trial name
- NCT00153842
- Testing
- Bexarotene (targretin)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Squamous Cell Carcinoma
Method Development and Assessment of the Effects of Tobacco Products on Oral Cavity Cells
Collection of tissues for analysis from patients undergoing elective neck dissection. The hypothesis of the study is that specific genetic alterations occur in head and neck cancers that have spread to regional and/or distant…
- Trial name
- H&N (NCT01484769)
- Where
- 3 sites in United States
- Sponsor
- University of Louisville
Head and Neck Cancer
Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00646659
- Testing
- cetuximab, carboplatin, cisplatin
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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