Clinical trials: Oral Cavity Disease
Healthy, Salivary Gland Disease
Salivary Evaluation in Healthy Volunteers
Saliva is critical in maintaining oral health and comfort. Our laboratory has investigated several disorders of salivary glands.
- Trial name
- NCT00001390
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Oral Lichen Planus
Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and is considered a precancerous condition.
- Trial name
- NCT05973097
- Testing
- total glucosides of paeony treatment, photodynamic therapy treatment, glucosides of paeony and photodynamic therapy combined treatment
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Trypanosomiasis, Trypanosomiasis, African
Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
This study is aimed at assessing the tolerability and pharmacokinetic parameters of SCYX-7158 in healthy volunteers. In animal models of both acute and chronic experimental Trypanosomiasis infections, SCYX-7158 shows highly…
- Conditions
- Trypanosomiasis, Trypanosomiasis, African, Protozoan Infections, Parasitic Diseases
- Trial name
- NCT01533961
- Testing
- SCYX-7158
- Where
- 2 sites in France
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Periodontitis
RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects
A sulcular incision will be made through each recession area and the tissues will be gradually undermined including the base of the interdental papilla.
- Trial name
- NCT04375618
- Testing
- RhEGF, Plain Collagen
- Where
- India
- Volunteers
- 30 people
- Sponsor
- SVS Institute of Dental Sciences
Coronavirus Disease 2019, Coronavirus Disease 2019 (COVID-19)
A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of Ibuzatrelvir
Healthy adults will be enrolled into this open-label, Phase 1 research study. Participants will spend about 9 nights and 10 days in the clinical research unit (CRU) and the total time in the study will be about 11 weeks.
- Conditions
- Coronavirus Disease 2019, Coronavirus Disease 2019 (COVID-19), COVID-19 (Coronavirus Disease 2019), Upper Respiratory Tract Infections
- Trial name
- NCT07552779
- Testing
- Ibuzatrelvir co-process API film coated tablet, Ibuzatrelvir filmcoated tablet
- Where
- Belgium
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
Aggressive Periodontitis
Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients
The purpose of this study is to determine whether full-mouth disinfection is effective in the initial periodontal treatment of generalized aggressive periodontitis on clinical parameters, gingival crevicular fluid interleukin-1β…
- Trial name
- NCT02466646
- Testing
- Klorhex® Gel, rinse and spray, Conventional IPT, Full-mouth IPT
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University
Sjogren's Syndrome
Hydroxychloroquine Blood Levels in Primary Sjögren Syndrome Patients
Introduction. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by chronic inflammatory infiltration of the salivary and lacrimal glands causing dry eye and mouth.
- Trial name
- 1ASSJHCQ (NCT04546542)
- Testing
- Parallel Assignment
- Where
- 2 sites in Brazil
- Volunteers
- 74 people
- Sponsor
- University of Sao Paulo General Hospital
Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance
Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS
The main objective of the proposed study is to evaluate if oral intake of EN formula preceding Gtube placement will impact tolerance upon placement and feeding via Gtube in pALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance, Enteral Nutrition Therapy
- Trial name
- NCT06609213
- Testing
- Medical Food
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Andrea Charvet
Oral Mucositis, Oral Cancer
Oral Care Protocol for the Management of Chemotherapy and Radiation Therapy-Induced Oral Mucositis
The purpose of this study is to determine the effects of a novel oral care protocol on the severity and pain of oral mucositis in patients receiving radiation and/or chemotherapy for head and neck cancers.
- Trial name
- OMDP (NCT02608879)
- Testing
- Oral Mucosa Deterging and Periodontal Debridement (OMDP), Standard of Care Oral Hygiene Instructions, Dental scaling, ultrasonic
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Peridontal Disease
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.
Since the researchers thought that Annexin A1, Lipoxin A4 and IL-1 Beta parameters, which have been found to be related to inflammatory conditions, may increase in periodontitis, a common inflammatory gum disease, we wanted to…
- Trial name
- Lipoxin A4 (NCT06700161)
- Testing
- Obtaining CGF from patients
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Eda Cetin Ozdemir
Electromyography, Eye-tracking
Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological and Control Subjects
The facial palsy is a frequent disease with a lot of etiologies. It has variable severities with sometimes heavy functional repercussions and different recovery potentials.
- Conditions
- Electromyography, Eye-tracking, Facial Palsy
- Trial name
- AQ2MF (NCT05581680)
- Testing
- dental impressions, Simultaneous MoCap and EMG acquisition, Eye-tracking acquisition for pathological subjects
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Periodontitis
Alb-PRF as an Adjunct to Nonsurgical Periodontal Therapy
Periodontitis is an inflammatory disease that damages the tissues supporting the teeth. Nonsurgical periodontal therapy is the standard initial treatment, but deep periodontal pockets may remain after treatment.
- Trial name
- NCT07794046
- Testing
- Nonsurgical Periodontal Therapy, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Cardiovascular Diseases, Periodontitis
Effects of Non-surgical Periodontal Therapy on Cardiovascular Risk
This study is to evaluate whether non-surgical periodontal therapy can help to control the cardiovascular risk among patients with moderate/severe periodontitis and at risk of cardiovascular disease.
- Trial name
- NCT05459727
- Testing
- Non-surgical periodontal therapy, Control periodontal treatment
- Where
- 2 sites in China
- Volunteers
- 376 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Gingival Recession Generalized Moderate
The Use of Coronary Displaced Flap and Deepithelialized Free Graft in the Treatment of Multiple Gingival Recessions
Successful treatment of multiple gingival recessions (MRG) is a major challenge in periodontal plastic surgery due to complicated predisposing anatomical features of the surrounding tissues, such as a thin gingival phenotype or a…
- Trial name
- NCT05664373
- Testing
- Coronally advanced flap and deepithelized free gingival graft
- Where
- Serbia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Graft Vs Host Disease, Oral Mucositis (Ulcerative)
Treatment of Oral Mucositis Using Platelet Rich Fibrin TREATMENT OF ORAL MUCOSITIS USING PRF
Oral mucositis (OM) is an inflammatory mucosal demolition frequently observed during treatments for neoplastic diseases such as chemotherapy or radiation therapy.
- Conditions
- Graft Vs Host Disease, Oral Mucositis (Ulcerative), Mesenchymal Stem Cells
- Trial name
- NCT05018754
- Testing
- TREATMENT OF ORAL MUCOSITIS USING PLATELET-RICH-FIBRIN (PRF)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Rome Tor Vergata
Oral Mucosal Disease
Clinical Research Core Dental Screening Protocol
This study will screen patients for eligibility in studies sponsored by the Craniofacial Genetics Section (HCGS), the Clinical Research Core (CRC), and other branches located within the National Institute of Dental and…
- Trial name
- NCT00090818
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Peri-Implantitis, Dental Implant Failed
Assessment of the Effects of Different Implant Abutment Occluding Materials on Dental Implant Health Parameters and Microbiology
The primary purpose of this study is to determine what effect, if any, do different dental materials used to seal the prosthetic screw channels of implant supported restorations have on dental implant health parameters and…
- Conditions
- Peri-Implantitis, Dental Implant Failed, Dental Implant Failure Nos
- Trial name
- NCT02625597
- Testing
- Cotton Pellet, Polytetrafluoroethylene Tape, Synthetic Foam
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Behcet's Disease
Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation)
This investigation was conducted to obtain the following information regarding the use of Adalimumab (Humira®) 40mg Syringe 0.8mL for Subcutaneous Injection in patients with Intestinal Behcet's Disease. 1.
- Trial name
- NCT01960790
- Volunteers
- 473 people
- Sponsor
- AbbVie
Periodontitis, Peri-Implantitis
Periodontitis and Inflammation
Today, to understand pathogenic mechanisms involved in periodontitis and peri-implantitis remains a challenge to identify biomarkers or therapeutic targets to improve prevention and screening, as well as the effectiveness of…
- Trial name
- CB-PARO (NCT04831060)
- Testing
- Periodontal or peri-implantitis treatment, Control treatment
- Where
- 2 sites in France
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Steven-Johnson Syndrome, Toxic Epidermal Necrolysis
Severe Cutaneous Adverse Reactions in Thailand
The multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in Thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in…
- Conditions
- Steven-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction With Eosinophilia and Systemic Symptoms, Acute Generalized Exanthematous Pustulosis
- Trial name
- ThaiSCAR (NCT02574988)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
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