Clinical trials: Oral Cavity Disease
Gingivitis, Bleeding Gum
Efficacy of Hyaluronic-acid and Hydrogen-Peroxide Mouthwash in Gingivitis Treatment
A clinical study to evaluate the efficacy and safety of a mouthwash containing Hydrogen Peroxide, Sodium Hyaluronate and Glycine in the prevention and management of complications associated gingivitis by film forming action.
- Trial name
- NCT04438421
- Testing
- Filming mouthwash formulation, enriched with Hydrogen Peroxide and Hyaluronic Acid, Chlorhexidine mouthwash
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Tooth Loss, Edentulous Jaw
Short Implants in Edentulous Mandible
Main aim of this study was to assess survival rates of short implants with a length of 4 mm in the edentulous mandible after 1, 3, and 5 years.
- Trial name
- NCT04838184
- Testing
- Dental Implants (Straumann Roxolid® / SLActive®)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Xerostomia, Hyposalivation
The Effect of Biotene® on the Symptoms of Xerostomia and Mastication and Swallowing
This study will compare the effects of Biotene® Oral Balance Moisturizing Gel (Biotene), an over-the-counter artificial saliva, that the effects of a sham condition on oral health-related quality of life, mastication, and…
- Trial name
- NCT04323384
- Testing
- Biotene® Oralbalance Moisturizing Gel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Gingivitis
Plaque Inhibitory Effect of Neutral Electrolysed Water in the Form of a Mouthwash in a 4-day Non-brushing Model
Electrolysed water (EOW) is produced by the electrolysis of sodium chloride in an aqueous solution, producing chlorine gas at the anode and sodium hydroxide and hydrogen at the cathode.
- Trial name
- NCT05709015
- Testing
- Neutral electrolyzed water, Chlorhexidine digluconate
- Where
- Slovenia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
L-PRF, Photodynamic Therapy
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria.
- Conditions
- L-PRF, Photodynamic Therapy, Aggressive Periodontitis
- Trial name
- NCT05043935
- Testing
- L-PRF with antimicrobial photodynamic therapy, antimicrobial photodynamic therapy without L-PRF
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Periodontal Diseases
The Dental Care Revolution: Health Education Using AI or Humanized Counseling on Plague Control and Periodontal Treatment Outcome in Patients With Periodontal Disease
The aim of this study was to evaluate the long-term effectiveness of an AI dental monitoring intervention on patients' periodontal disease, preventive behaviors and motivation.
- Trial name
- NCT06083649
- Testing
- The AI-assisted tool used in this study was called Dental Monitoring (DM).
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Recurrent Herpes Labialis
A Study to Compare Sitavig (Acyclovir) Buccal Tablet With a Placebo in the Treatment of Herpes Labialis in Participants Whose Immune System Works Normally
Researchers are looking for a better way to treat people who have recurrent herpes labialis, also known as cold sores. This is a type of viral infection that causes redness and blisters on the mouth and lip and that recurs.
- Trial name
- NCT05098938
- Testing
- Acyclovir 50mg buccal/topical tablet, BAYM008894/UI1614773
- Where
- United States
- Volunteers
- 2,020 people
- Sponsor
- Bayer
Carcinoma, Squamous Cell, Mouth Neoplasms
Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers
The purpose of this study is to determine if there is a correlation between tumor response after 3 doses of chemotherapy by induction using Docetaxel, Cisplatine and 5-Fluorouracile for advanced stage epidermoid carcinomas of the…
- Conditions
- Carcinoma, Squamous Cell, Mouth Neoplasms, Oropharyngeal Neoplasms, Laryngeal Neoplasms
- Trial name
- APPROCHE ORL (NCT01104714)
- Where
- 14 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Treatment of Periodontitis, Guided Biofilm Therapy
Comparison of Current Subgingival Debridement Methods
Our study aimed to compare the effectiveness of current subgingival debridement methods used in the treatment of Stage 1 and Stage 2 periodontitis patients, the aesthetic condition achieved after these treatments, and the pain…
- Conditions
- Treatment of Periodontitis, Guided Biofilm Therapy, Subgingival Plaque, Subgingival Debridement
- Trial name
- NCT06835452
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Periodontal Diseases
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects
The quantification of the proteomes : L-plastin, lipocalin and adiponectin was analysed in the subgingival tissue samples of generalized severe chronic periodontitis patients with and without diabetes mellitus.The demographic and…
- Trial name
- NCT03391349
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis, Obesity
Effect of Periodontal Debridement on Leptin Levels in Obese
The main purpose of the study is to quantify of Leptin hormone in patients with normal weight, class I obesity, class II obesity and periodontitis, before and after scaling and root planning (SRP) and correlate the Body mass…
- Trial name
- NCT04417478
- Testing
- Scaling and root planning
- Where
- Chile
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Andres Bello
Gingival Bleeding, Prosthesis Failure, Dental
Comparison of Effectiveness of Gingival Displacement Using Retraction Cord and Aluminum Chloride Gel
This study aims to compare the horizontal gingival displacement by using a retraction cord and aluminum chloride gel, and also to determine the time taken for placement and hemorrhage after the procedure by using a retraction…
- Conditions
- Gingival Bleeding, Prosthesis Failure, Dental, Tissue Injury
- Trial name
- NCT07255976
- Testing
- knitted cotton retraction cord, aluminum chloride gel
- Where
- Pakistan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Newborns, Oral Hygiene
Effect of Oral Hygienization in Newborn on Candida Spp Colonization
Oral hygiene is one of the most accessible and well-known strategies for the prevention of dental caries. The benefits of this practice after tooth eruption are well established in the literature.
- Conditions
- Newborns, Oral Hygiene, Candidiasis, Oral, Behavior
- Trial name
- NCT04410250
- Testing
- oral hygiene
- Where
- Brazil
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Gingivitis, Oral Disease
Metagenome Resilience in Experimental Gingivitis
This study aims to identify new biomarkers that indicate the resilience of individuals to developing oral disease. An 'experimental gingivitis' model will be employed in which subjects will refrain from oral hygiene in one…
- Trial name
- NCT05389124
- Testing
- Partial abstinence from oral hygiene
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Oral Cancer
Polarized Reflectance Spectroscopy for Oral Lesions
In this study the investigators are conducting research to determine whether a new optical device using polarization reflectance spectroscopy can help doctors or dentists identify abnormalities in the mouth that require…
- Trial name
- PolProbe (NCT01604759)
- Testing
- Polarized Reflectance Spectroscopy System
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- British Columbia Cancer Agency
Valve Heart Disease, Anticoagulants; Increased
Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy
Guidelines recommended that patients with bioprosthetic heart valves (BHV) only need 6 months oral anticoagulation therapy after operation.
- Trial name
- REDUCE (NCT03885180)
- Testing
- Warfarin Sodium
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Wuhan Asia Heart Hospital
Oral Lichen Planus
The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus
Oral Lichen Planus (OLP) is an inflammatory disease of mucosal and skin with unknown etiology. The prevalence rate in England is reported to be between 1-2.4%.
- Trial name
- CABRIO (NCT03052179)
- Testing
- Poly-biotic
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Periodontitis Chronic Generalized Severe, Gingivitis
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Periodontal disease is a chronic progressive state of inflammation pertaining to supporting tissues of the dentition that culminates in loss of the affected teeth.
- Conditions
- Periodontitis Chronic Generalized Severe, Gingivitis, Inflammatory Response
- Trial name
- NCT06016023
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Stevens-Johnson Syndrome
Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye
The purpose of this study is to evaluate the efficacy of 0.05% cyclosporin ophthalmic emulsion (Restasis) in patients with Stevens-Johnson syndrome that have dry eyes by subjective symptoms and signs.
- Trial name
- NCT01488396
- Testing
- 0.05%cyclosporin eye drop
- Where
- Thailand
- Volunteers
- 31 people
- Sponsor
- Mahidol University
Anemia, Dialysis-Dependent Chronic Kidney Disease
Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)
A multicenter, randomized, open-label, active-controlled Phase 3 study for the correction or maintenance treatment of anemia in participants with incident dialysis-dependent chronic kidney disease (DD-CKD).
- Trial name
- NCT02865850
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 118 sites in United States, Argentina and 9 more
- Volunteers
- 369 people
- Sponsor
- Akebia Therapeutics
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