Clinical trials: Oral Cavity Disease
Periodontitis
Clinical Effects and Metagenomic Analysis of Using an Air Polishing Device With Erythritol Powder Compared to Scaling and Root Planing in Periodontal Maintenance Therapy.
Periodontitis is a chronic, multifactorial disease primarily driven by the accumulation of bacterial deposits. Treatment involves the mechanical removal of the biofilm, traditionally performed by scaling and root planing (SRP).
- Trial name
- NCT07344805
- Testing
- AIRFLOW® Prophylaxis Master, Cavitron® ultrasonic scaler
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Cardenal Herrera University
Asthma, Candidiasis, Oral
Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 mcg BID
This Pilot study is designed to explore the rate of local side effects of fluticasone as delivered by Advair and to determine the best outcome measure to assess these effects.
- Conditions
- Asthma, Candidiasis, Oral, Voice Disorders
- Trial name
- NCT00235053
- Testing
- fluticasone/salmeterol DISKUS 250/50
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Allergy & Asthma Medical Group & Research Center
Buccal Mucosa Squamous Cell Carcinoma, Floor of Mouth Squamous Cell Carcinoma
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer.
- Conditions
- Buccal Mucosa Squamous Cell Carcinoma, Floor of Mouth Squamous Cell Carcinoma, Gingival Squamous Cell Carcinoma, Hard Palate Squamous Cell Carcinoma
- Trial name
- NCT04333537
- Testing
- Chest Radiography, Computed Tomography, Fludeoxyglucose F-18
- Where
- 107 sites in United States, Canada
- Volunteers
- 686 people
- Sponsor
- NRG Oncology
Diabetes Mellitus., Chronic Periodontitis
Periodontal Treatment in Non-controlled Type 2 Diabetes Mellitus Patients. Clinical Trial
Periodontitis is an infectious disease that destroys the tooth supporting tissues and triggers a local and systemic immune response.
- Trial name
- FONIS12I2106 (NCT01904422)
- Testing
- conventional periodontal treatment
- Where
- Chile
- Volunteers
- 87 people
- Sponsor
- Universidad de los Andes, Chile
Periodontitis
Oral Gel Containing PHTALOX® as an Adjuvant in the Treatment of Periodontal Disease
Periodontitis, a chronic inflammatory condition of the periodontal tissues, impacts not only the patient's oral and systemic health but also has significant social and economic implications.
- Trial name
- NCT06731777
- Testing
- Scaling and root planing plus PHTALOX® oral gel vehicle, Scaling and root planing plus 0.12% chlorhexidine oral gel, Scaling and root planing plus PHTALOX® oral gel
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal de Alfenas
Lysosomal Storage Disease, Lung Diseases
Biomarker for Maroteaux-Lamy Disease (BioMaroteaux)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Maroteaux-Lamy disease from blood
- Conditions
- Lysosomal Storage Disease, Lung Diseases, Obstructive Sleep Apnoea, Macroglossia
- Trial name
- BioMaroteaux (NCT01458613)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Carcinogenesis, Oral Cancer
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor.
Study on the carcinogenesis of Gα12 in oral cancer, and chemopreventive possibility for the treatment of oral cancer using Ga12 inhibitor.
- Trial name
- NCT01919580
- Where
- Taiwan
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dental Caries, Gingivitis
Domiciliary Professional Oral Care for Dependent Elderly
Today's increase of dentate elderly, many of them dependent, is a challenge, both according to the personal daily oral hygiene and dentistry.
- Trial name
- NCT02669979
- Testing
- Intervention
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
A Study of Bisantrene Combined With Cytarabine or With Decitabine for Adult Subjects With Extramedullary AML and MDS
This is a two strata Phase 1b study to assess the safety and efficacy of bisantrene (RC110) in combination with a) cytarabine arabinoside (Ara-C) treatment for patients with relapsed or refractory (R/R) Acute Myeloid Leukemia…
- Conditions
- Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia, Higher Risk Myelodysplastic Syndrome
- Trial name
- BISECT (NCT05456269)
- Testing
- Bisantrene Dihydrochloride (high dose), Bisantrene Dihydrochloride (low dose), Cytarabine Hydrochloride
- Where
- Australia
- Sponsor
- Racura Oncology Ltd
Tooth Loss
Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets
The goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with Bio-Oss Collagen® at 3 and 6 months following tooth…
- Trial name
- NCT06654141
- Testing
- Alveolar ridge preservation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Xerostomia, Salivary Gland Diseases
Efficacy Study of a Ginger and Cardamom Gelatin for Xerostomy in Terminally Ill Patients
Xerostomia or dry mouth is the subjective feeling that there is not enough saliva in your mouth. It's a frequent symptom in terminally ill patients receiving palliative care, reducing their quality of life and comfort.
- Conditions
- Xerostomia, Salivary Gland Diseases, Mouth Diseases
- Trial name
- NCT01915966
- Testing
- Cardamom, ginger and orange juice gelatin, Camomile infusion with lemon juice
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundacio Salut i Envelliment UAB
Peri-Implantitis and Peri-implant Mucositis
The Use of Adjunct Oxygen High-Level Laser Therapy on the Clinical and Microbiological Outcomes of Peri-implant Disease
The goal of this clinical trial is to learn whether using a special light-activated treatment called photodynamic therapy, or more specifically, its modified version called oxygen high-level laser therapy, using a high-powered…
- Trial name
- NCT07287956
- Testing
- Oxygen high-level laser therapy (Diode laser and hydrogen peroxide), Diode laser therapy
- Where
- Jordan
- Volunteers
- 16 people
- Sponsor
- King Abdullah University Hospital
Gingivitis, Oral Health
Frequency of Oral Hygiene
The purpose of this study is to evaluate the frequency of oral hygiene in the maintenance of gingival health in patients with an adequate method of oral hygiene.
- Trial name
- NCT01630837
- Testing
- frequency of oral hygiene
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Periodontitis
Effects of Prebiotic Oral Healthcare Products as an Adjunct to Non-surgical Periodontal Therapy
The aim of this study is to determine the impact of a prebiotic toothpaste and mouthrinse in periodontitis patients as an adjunct to scaling and rootplaning.
- Trial name
- NCT02520375
- Testing
- Prebiotic, Control
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tooth Loss, Bone Graft; Complications
Patient-reported Outcome Measures After Implant Placement With Contour Augmentation Procedure
Maintaining the general health and well-being of patients is the main goal of dental therapy. However, tooth extraction is indicated when teeth cannot be maintained in a status compatible with health, adequate esthetics…
- Conditions
- Tooth Loss, Bone Graft; Complications, Patient Satisfaction, Patient Acceptance of Health Care
- Trial name
- NCT05890170
- Testing
- Patient Reported Outcomes Measures
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Bern
Head and Neck Cancer, Precancerous Condition
Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01084083
- Testing
- cetuximab, intensity-modulated radiation therapy (IMRT), Paclitaxel
- Where
- 121 sites in United States
- Volunteers
- 90 people
- Sponsor
- Eastern Cooperative Oncology Group
Systemic Mastocytosis, Aggressive (ASM), Leukemia, Mast Cell
Phase 2 Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia
The safety and efficacy of midostaurin (PKC412), a novel investigational drug, will be evaluated on the basis of response rate, when administered to patients with aggressive systemic mastocytosis (ASM) or mast cell leukemia (MCL)
- Conditions
- Systemic Mastocytosis, Aggressive (ASM), Leukemia, Mast Cell, Hematological Non-mast Cell Lineage Disease (AHNMD)
- Trial name
- NCT00233454
- Testing
- Midostaurin
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Jason Robert Gotlib
Ornithine Transcarbamylase Deficiency
Study to Characterize Rate of Ureagenesis in Patients With Ornithine Transcarbamylase (OTC) Deficiency
The objectives of the study are to characterize urea production rates in patients with OTC, characterize the association of rate of ureagenesis and disease severity in OTC patients, characterize the association of rate of…
- Trial name
- NCT04717453
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Apical Periodontitis
Association Between Apical Periodontitis and Psoriasis Vulgaris
The aim of the present cross-sectional study is to assess the presence of AP and caries in psoriasis vulgaris individuals and to examine whether these medications influence these oral conditions.
- Trial name
- NCT06436339
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- University of Siena
Herpes Labialis
Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in Adolescents
The Purpose of this study is to evaluate the safety of ME-609 for the treatment of recurrent herpes labialis in adolescents.
- Trial name
- NCT00375570
- Testing
- ME-609
- Volunteers
- 254 people
- Sponsor
- Medivir
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