Clinical trials: Oral Cavity Disease
Endometriosis
Oral Health and Endometriosis: A Cohort Study
A survey has been conducted thanks to a questionnaire composed of 45 questions. The study group was composed of 4079 women affected by endometriosis, recruited from dedicated communities present on the social network Facebook.
- Trial name
- Oral-Endomet (NCT06753162)
- Where
- Italy
- Volunteers
- 4,079 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Chronic Periodontitis, Type 2 Diabetes Mellitus
Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy
1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients? 2. Does their level change after periodontal therapy?
- Trial name
- NCT02174146
- Testing
- non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession
MINST Versus Conventional Subgingival Instrumentation In RT1 Gingival Recession
Gingival recession is a common condition and its extent and prevalence increase with age. Majority of patients probably present with localized and shallow gingival recession that need a specific treatment because they are…
- Trial name
- NCT06044727
- Testing
- Minimally invasive non surgical periodontal therapy, Conventional subgingival instrumentation
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Health
Evaluation of a Daily Oral Care Lozenge on Oral Health and Quality of Life in Older Adults
The assessment of a daily oral care lozenge (PTx800) will be compared to a placebo control in a cohort of older adults who visit adult senior centers and who also have mild to moderate gingivitis.
- Trial name
- NCT03693027
- Testing
- PTx800 lozenges
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Primal Therapies Inc.
SARS-CoV Infection
Oral Manifestation in Patients With SARS-CoV2 Infection.
The oral cavity is particularly susceptible to viral infection with several viruses such as herpes simplex virus, cytomegalovirus and Zika virus because of its structures, especially salivary glands and soft tissues Moreover…
- Trial name
- NCT04821986
- Where
- Egypt
- Volunteers
- 583 people
- Sponsor
- Fayoum University
Chronic Periodontitis
Comparison of Alendronate With Atorvastatin in Chronic Periodontitis
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of two local drug delivery systems containing 1% ALN gel and 1.2% ATV gel in treatment of…
- Trial name
- NCT02455869
- Testing
- SRP and Atorvastatin, SRP and Alendronate
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis, Adult
Protozoans in Biofilm From Patients With Periodontitis
The buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients.
- Trial name
- Paro-Proto (NCT03240666)
- Testing
- non applicable
- Where
- France
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Oral Mucositis, Head and Neck Cancer
Dose Ranging Study to Assess the Safety and Efficacy of SCV-07 for the Delay to Onset of Severe Oral Mucositis in Patients Receiving Chemoradiation Therapy for Head and Neck Cancer
Oral Mucositis (OM) is a painful and debilitating side effect of many of the drug or radiation regiments used to treat cancer. This study examines the investigational drug SCV-07 and it's possible application in treating Oral…
- Trial name
- SCV-07 OM (NCT00756951)
- Testing
- SCV-07
- Where
- 19 sites in United States
- Volunteers
- 59 people
- Sponsor
- SciClone Pharmaceuticals
Parkinson Disease
Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease
A phase 2a multicenter, randomized, double-blind, placebo-controlled multiple dose study to evaluate the safety, tolerability, pharmacokinetics, of HBI-002, an oral low-dose carbon monoxide (CO) liquid drug product, administered…
- Trial name
- LoCaMoTE-PD (NCT07005180)
- Testing
- HBI-002
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Hillhurst Biopharmaceuticals, Inc.
Periodontitis
Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment
This study evaluates the effect of the systemic administration of azithromycin as a therapy associated with non-surgical periodontal treatment, in the clinical and microbiological variables of patients with Severe Periodontitis…
- Trial name
- NCT03629288
- Testing
- Lactose tab, Azithromycin
- Where
- Chile
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Andres Bello
Anemia, Iron-Deficiency, Kidney Failure, Chronic
Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents
This study compares the effect of Ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are receiving erythropoietic agents…
- Trial name
- NCT00224042
- Testing
- Sodium Ferric Gluconate complex in sucrose, Ferrous sulfate tablets
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 52 people
- Sponsor
- Watson Pharmaceuticals
Head and Neck Cancer, Oral Complications of Radiation Therapy
Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer
RATIONALE: Iseganan hydrochloride may be effective in preventing or lessening oral mucositis in patients who are receiving radiation therapy for head and neck cancer.
- Conditions
- Head and Neck Cancer, Oral Complications of Radiation Therapy, Radiation Toxicity
- Trial name
- NCT00022373
- Testing
- iseganan HCl oral solution, management of therapy complications
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms
Neoadjuvant Chemoimmunotherapy (Camrelizumab + Paclitaxel + Carboplatin) for Resectable HNSCC
This phase II study evaluates the efficacy and safety of neoadjuvant chemoimmunotherapy consisting of camrelizumab (PD-1 inhibitor), paclitaxel, and carboplatin in patients with resectable locally advanced (Stage III-IVA)…
- Conditions
- Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Oral Cavity Neoplasm
- Trial name
- NeoCamre-HN (NCT07400094)
- Testing
- Camrelizumab, Paclitaxel, carboplatin
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Radiological Centre of the Ministry of Health of Russia
Hematologic Malignancies
Repeat Dose Safety Study for Compound to Treat Hematologic Cancer
The purpose of this study is to characterize the safety and tolerability of repeat doses of compound GSK2110183 in subjects with hematologic cancer.
- Trial name
- NCT00881946
- Testing
- GSK21110183
- Where
- 4 sites in Australia, Canada and 1 more
- Volunteers
- 73 people
- Sponsor
- Accenture
Edentulous Jaw
Intra Oral Scanning of Edentulous Arches
the aim of this study is to compare the influence of different palatal vault configurations on the accuracy and scan speed of IO scans in cases of completely edentulous arches.
- Trial name
- NCT06146153
- Testing
- digital impression
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Gingivitis, Plaque
ToothWave Calculus Reduction and Accumulation Prevention Study
The objective of the study is to evaluate the safety and efficacy of the home-use device ToothWave (Model H7001) for calculus reduction and the prevention of calculus accumulation.
- Conditions
- Gingivitis, Plaque, Calculus, Dental
- Trial name
- NCT04596761
- Testing
- RF-utilizing powered toothbrush
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Swallowing Disorder, Oropharyngeal Dysphagia
Effectiveness of an Optimal-Massive Intervention in Older Patients With Dysphagia
The aim of this study is to evaluate the efficacy of an optimal-massive intervention (OMI) based on increasing shear viscosity of fluids, nutritional support with oral nutritional supplements (ONS) and triple adaptation of food…
- Conditions
- Swallowing Disorder, Oropharyngeal Dysphagia, Respiratory Infection, Malnutrition
- Trial name
- OMI (NCT04581486)
- Testing
- Optimal-Massive Intervention, Control (standard clinical practice)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital de Mataró
Cardiovascular Diseases, Coronary Disease
Myocardial Infarction and Past Oral Contraceptive Use
To evaluate whether the long-term use of oral contraceptives, after discontinuation, was associated with an increased incidence of first nonfatal myocardial infarction among women above the age of 50.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005173
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Dry Socket
Role of Vitamin E in Reducing Dry Socket
90 female patients seeking extraction of a single tooth in the lower posterior region were divided randomly into 45 patients received vitamin E inside the socket after extraction (study group) and 45 patients didn't receive…
- Trial name
- NCT05984173
- Testing
- Vitamin E application
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Parkinson Disease
Pharmacokinetic Profile of BIA 6-512 in Healthy Elderly Subjects Versus Healthy Young Subjects
the purpose of the study was to the compare pharmacokinetic profile of BIA 6-512 in healthy elderly subjects versus healthy young subjects after single and repeated oral administration of 200 mg BIA 6-512.
- Trial name
- NCT03095105
- Testing
- 200 mg BIA 6-512
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
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